Paraxanthine Powder

What is Paraxanthine?

Biochemically, caffeine is a methylxanthine that occurs naturally in the seeds, fruits, nuts, and leaves of several tropical plants, but its most famous source is of course coffee beans. It is widely used in nitrogen pumps, nootropics, marathon sports supplements, functional foods, and energy drinks.

Paraxanthine is a natural plant compound found in coffee, cocoa fruit, vine, and the stamens of citrus flowers. It is also the main metabolite of caffeine.
In the body, caffeine is demethylated to dimethylxanthines in the liver by the cytochrome P450 enzyme system (specifically the CYP1A2 isozyme).
Paraxanthine accounts for approximately 80% of ingested caffeine, with smaller proportions of caffeine being metabolized to theobromine and theophylline. Studies have shown that 11% of caffeine is ultimately converted to theobromine and 4% to theophylline.
(Paraxanthine Powder) is a new caffeine substitute that has the stimulant effects of caffeine but without the drawbacks associated with its metabolites. With a shorter half-life and superior cognitive benefits, it offers a safe and effective solution for consumers seeking a high-impact stimulant.

Caffeine VS Paraxanthine

Central Nervous System Effects
Paraxanthine has been shown to have the same effects on the central nervous system as caffeine. In one study, subjects were given either 2 or 4 mg/kg of caffeine or paraxanthine or a placebo after three days of abstinence from methylxanthines.
Both caffeine and paraxanthine significantly increased diastolic blood pressure, plasma epinephrine levels, and free fatty acids, suggesting their potent and fat-burning abilities.
Similar magnitudes of response were produced at 4 mg/kg; however, 2 mg/kg of caffeine appeared to produce a greater response than paraxanthine.
Thus, caffeine and paraxanthine have similar sympathomimetic effects.

Improves Cognition, Short-Term Memory, and Sustained Attention

Paraxanthine has been tested in clinical trials for its ability to increase cognitive flexibility, sustain attention, improve working memory, and inhibitory control. In one clinical trial, acute ingestion of paraxanthine was observed to improve cognition and short-term memory, and aid in sustaining attention.

The trial used a randomized, double-blind, placebo-controlled, crossover and counterbalanced method and included 12 healthy male and female subjects (24±5 years old, 170.0±12 cm, 72.9±19 kg, 24.8±4 kg/m2) who were randomly assigned to take placebo (PL) or 200 mg paraxanthine.
Participants completed a stimulant sensitivity and side effects questionnaire and then took a battery of standard cognitive function tests, including the Berg-Kad sorting task test (BCST), an executive function test that assesses long-term thinking, including reasoning, learning, executive control, and attention shifting; and the go/no-go test (GNG), which assesses sustained attention and response control through reaction time and accuracy to visual stimuli;

Improving cognitive function and motor performance

In another double-blind, placebo-controlled, crossover, and counterbalanced trial, 13 trained runners (27.1±5 years, 68.6±9 kg, 22.2±2.7 kg/m2, 15.7±5% body fat, 53.7±11 mL/kg/min VO2 peak)

were randomly assigned to take 400 mg placebo (PL), 200 mg PL + 200 mg caffeine (CA), 200 mg PL + 200 mg paraxanthine (PX), or 200 mg CA + 200 mg caffeine (CA). PX
(CA+PX), with a 7-day washout period between treatments.
A fasting blood sample was collected from each participant, and a pre-supplement side effect questionnaire as well as the BCST and PVTT were completed. Participants then rested for 60 minutes, repeated the test, ran 10 km on a treadmill (48.4±6.7 minutes), and then performed a set of post-exercise tests.
Analysis of the BCST results showed that paraxanthine increased correct responses and reduced errors, while caffeine increased errors. After exercise, total errors increased in all groups except the paraxanthine group, indicating fatigue. Paraxanthine significantly improved errors, reducing them by 10.6%, while caffeine increased them by 23.3%. The paraxanthine group also had faster post-exercise reaction times than the placebo group.
In addition, paraxanthine also showed faster reaction times in both the pre-exercise test (compared to placebo) and the post-exercise test (compared to caffeine).
Results from this clinical trial suggest that acute paraxanthine supplementation (independent of caffeine) improves cognition and reduces fatigue before and after exercise. The trial also suggests that adding caffeine to paraxanthine does not provide any additional benefits. Paraxanthine Increases Muscle Mass, Strength, and Endurance
The effects of 28 days of paraxanthine supplementation on muscle mass, strength, and endurance performance were evaluated compared to other common ingredients often used in sports supplements, including L-theanine, α-GPC, and taurine.
Five groups of male Swiss albino mice were orally administered paraxanthine (20.5 mg/kg/day, human equivalent dose [HED] 100 mg), L-theanine (10.28 mg/kg/day, HED 50 mg), α-GPC (41.09 mg/kg/day, HED 200 mg), taurine (102.75 mg/kg/day, HED 500 mg), or a control (carboxymethylcellulose) for four weeks.

Exercise performance was assessed using forelimb grip strength and treadmill endurance exercise. All animals underwent treadmill training for 60 minutes, 5 days per week. Blood was drawn for analysis of lipid profiles, liver health, renal function, and nitric oxide levels.

Paraxanthine significantly improved forelimb grip strength by 17%, treadmill performance by 39%, gastrocnemius and soleus muscle mass by 14% and 41%, respectively, and nitric oxide levels by 100% compared to the control group, while reducing triglycerides, total cholesterol, and LDL, and increasing HDL compared to the control, as well as L-theanine, α-GPC, and taurine.

The results of this preliminary study suggest that paraxanthine is an effective ingredient for improving exercise performance compared to the control, L-theanine, α-GPC, and taurine.

Safety Profile
Toxicology studies determined the LD 50 (the dose of a substance that causes death in 50% of test animals) of paraxanthine to be 1,601 mg/kg body weight. 5J The LD 50 of caffeine is much lower at 192 mg/kg, indicating that caffeine is significantly more toxic than paraxanthine alone. In addition, the LD50s of the caffeine metabolites theobromine and theophylline are 1,265 mg/kg and 25 mg/kg, respectively. These findings suggest that caffeine may be more toxic because its metabolites are not paraxanthine, further supporting the idea that paraxanthine is a means of achieving the central nervous system stimulatory effects of caffeine without the side effects that may be attributed to other metabolites of caffeine.

Paraxanthine supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality Paraxanthine Powder 99% and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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