L-selenomethionine powder

What is L-selenomethionine powder?

L-selenomethionine powder is a white to off-white solid powder at room temperature and pressure. It has a certain solubility in water and is soluble in alcoholic organic solvents, but is difficult to dissolve in ether organic solvents. It is a chiral amino acid substance and is also the main natural food form of selenium. It has a variety of physiological activities, including enhancing sperm motility, increasing the body's antioxidant capacity and improving immunity. It has a significant role in the field of basic biochemistry research. Good application.
It is a selenochiral amino acid that contains an active amino acid unit in its structure and has general physical and chemical properties of common amino acid substances. It can undergo significant color reaction with ninhydrin substances. Due to the presence of selenium, L-selenomethionine is relatively sensitive to common oxidants, and is prone to oxidative deterioration when exposed to oxidants. It is the L-isomer of selenomethionine and is the main natural food form of selenium. It can also increase the expression of glutathione peroxidase. It is the most important natural form of selenium found in nature. It can be produced by fine chemical synthesis process. The product has unique ingredients, high purity (≥98%) and high bioavailability.
As a feed additive for poultry and livestock, selenoamino acids have the characteristics of improving the quality of poultry and livestock products, enhancing animal reproductive capacity, improving immunity, high absorption rate, and strong biological activity. It has high bioavailability and can effectively provide the selenium required by the human body. It is considered one of the safer selenium supplements.

Synthesis method:

Common methods include liquid ammonia method, methyllithium method, aminobutyrolactone hydrobromide method, methylselenylpropionaldehyde method, dihaloethylpiperidinedione method, etc.

1. Starting from methionine, the target compound is obtained through a 7-step reaction. The total yield is less than 30%. The process uses expensive chemical reagents such as methyllithium (extremely flammable) and tributoxyboron, and there is one step in the process. Using hydrobromide halogenation under strong acidic conditions requires anhydrous and anaerobic conditions. The requirements for equipment and operations are very high, making it difficult to achieve large-scale production.

2. Starting from γ-butyrolactone, the target product is synthesized through five steps including bromination, amination, and addition. The synthesis process is as follows. The reaction finally obtains DL selenomethionine, with a yield of 33%. However, this synthesis route uses highly toxic liquid bromine, which is difficult to operate and requires high equipment.

3. It has the advantages of high product yield, simple synthesis process, easy availability of raw materials, mild reaction conditions, and easy industrialization. The synthesis is divided into two steps. The specific steps are: use DL homoserine as raw material, add hydrobromic acid solution, cool to room temperature after the reaction is complete, cool and crystallize, filter, and obtain DL 2 amino 4-bromobutyric acid hydrogen bromide. Acid salt, the reaction formula is as follows:

Then, use ethanol as the solvent, slowly add selenium powder to NaBH4 under an ice bath, and obtain NaHSe after the reaction is complete; then slowly add NaHSe dropwise to DL 2 amino 4-bromobutyric acid hydrobromide at room temperature. After reacting for 1 hour, slowly add methyl iodide dropwise to continue the reaction until it is complete, adjust the pH value of the reaction solution to 5-6, and dehydrate to obtain the target product DL selenomethionine. The reaction formula is as follows:

The specific experimental steps are: (1) Synthesis of DL 2 amino 4-bromobutyric acid hydrobromide: In the reaction kettle, add 0.60 kgDL homoserine, and at the same time add ethanol and water at a volume ratio of 1:1. Mix solvent 2L, add 2.0kg (density: 1.38g/cm3) 40% hydrobromic acid, heat to 70°C for 1.5h, cool to room temperature, crystallize by cooling, filter to obtain DL 2 amino 4-bromobutyrate hydrogen Bromate, yield 90%.
(2) Synthesis of NaHSe: Under ice bath, add 0.19 kg NaBH4 to 1L ethanol solution, slowly add 0.79 kg Se powder, and connect an air pressure balance device at the same time. After the dropwise addition is completed, continue the incubation reaction for 1 hour.
(3) Synthesis of DL selenomethionine: In a 5L reaction kettle, slowly add the NaHSe obtained in step (2) to the DL 2 amino 4-bromobutyric acid hydrobromide obtained in step (1), After reacting for 1 hour, continue to slowly add 0.64 kg iodomethane dropwise. After reacting at room temperature for 12 hours, adjust the pH value to 5, filter and dehydrate, and obtain the target product white DL selenomethionine product with a yield of 86%.
The core of the synthetic route of this method relies on the generation of nucleophilic NaHSe and completes the transformation of key steps. This synthesis method has the advantages of high product yield, simple synthesis process, easily available raw materials, mild reaction conditions, and easy industrialization.

Efficacy and role:

1. Antioxidant effect: It is a powerful antioxidant that can help the body remove free radicals and protect cells from oxidative damage. In addition, it can enhance the antioxidant capacity of cells and prevent cell death caused by oxidative reactions.
2. Improve cardiovascular health
It can lower cholesterol levels in the blood and reduce fat deposits in blood vessels, thereby reducing the risk of cardiovascular disease. At the same time, it can also reduce fibrinogen levels in the blood and prevent the formation of blood clots.
3. Enhance immunity
It can enhance the body's immunity, increase the activity of white blood cells, and increase the production of antibodies. In addition, it can promote the activity of T lymphocytes and enhance the body's resistance.
4. Promote growth and development
For children, it plays a vital role in the growth and development process. It can promote the growth of bones, enhance muscle strength, and enable children to grow healthier.
5. Other functions
In addition to the above effects, L-selenomethionine also has anti-fatty liver effects, a certain protective effect on myocardium, antihypertensive effects and antidepressant properties.

Formulation
Capusle Formulation

Tablet Formulation
 

Solid Drink Formula

Certificates

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