Bulk Melatonin Powder

What is melatonin powder?

Melatonin is an endogenous hormone secreted by a part of the human brain called the pineal gland. It is also known as the night hormone. It is an important messenger that helps the body enter night mode. Current research has found that melatonin secretion has a circadian rhythm. It is low during the day, gradually increases after nightfall, reaches a peak from 23:00 to 3:00 a.m., and then drops sharply before dawn.

Bulk Melatonin Powder is a hormone produced in the pineal gland and also found in plants and microorganisms. It was discovered and named by American dermatologist Aaron Lerner in 1958. It is mainly related to circadian rhythm and seasonal reproduction regulation.

In most animals, melatonin is synthesized and secreted primarily at night (converted from tryptophan). It is also synthesized in many tissues and cells, including the retina, bone marrow cells, platelets, gastrointestinal tract, skin, or lymphocytes. cell.

Pure melatonin powder receptors are scattered throughout the body and appear to be multi-purpose physiological signals that are involved in the control of many physiological processes, thereby affecting sleep, reproduction, molting, immune response, energy balance and behavior.

In addition, it has direct and indirect antioxidant properties, and there is strong evidence that this compound can counteract the harmful effects of reactive oxygen species and nitrogen in different systems.

What does Pure melatonin powder do?

1. Good for bone health

A systematic analysis showed that oral melatonin increases osteocalcin. The underlying mechanism may be related to the fact that melatonin affects the formation of osteoblasts and osteoclasts through molecules such as MT2 melatonin receptor, MEK1/2 and MEK5, thereby preventing bone loss. For perimenopausal and postmenopausal women, melatonin may have positive effects on bone health.

2. Good for depression

A systematic analysis showed that oral melatonin can improve depression. If you have depression and your symptoms are worse when you don't get enough sleep, melatonin may help.

3． Improve the success rate of in vitro artificial insemination

Oral administration of melatonin during in vitro fertilization treatment increases the number of mature oocytes and has a tendency, albeit not a significant one, to increase clinical pregnancy rates. For in vitro artificial insemination treatment, melatonin may be helpful, but it is limited by the small sample size and more research is needed to further verify it.

4． Beneficial for weight control

Studies have shown that supplementation with larger doses of melatonin (doses ranging from 3 to 10 mg per day, and intervention times ranging from 3 to 48 weeks) can reduce body weight.

5. Beneficial for children with autism

According to statistics, up to 89% of autistic children have sleep problems, and the presence of sleep disorders may have a negative impact on prognosis. A meta-analysis (including 5 randomized, double-blind, placebo-controlled studies on autism in children) found that the use of melatonin can help improve sleep parameters (including sleep duration and time to fall asleep). Additionally, melatonin appears to improve daytime behavior in people with autism, with few side effects.

6. anti-inflammatory effect

The study found that melatonin supplementation significantly reduced TNF-α (tumor necrosis factor) and IL-6 (interleukin-6) levels, but had little effect on CRP (C-type reactive protein) levels. Melatonin supplementation can help reduce pro-inflammatory mediators.

7． Beneficial for migraines

A comprehensive analysis (including 25 randomized controlled trials with a total of 4499 migraine patients) showed that oral melatonin can help improve the frequency of migraine attacks. Among all the investigated interventions, oral melatonin 3 mg before bedtime is the most ideal pharmaceutical intervention and has the best improvement.

8. Improve primary insomnia

Primary insomnia is simply unexplained insomnia. That is, insomnia that is not caused by disease, mental or environmental causes.

The main symptoms of primary insomnia are difficulty initiating or maintaining sleep, or having non-restorative sleep that lasts for at least 1 month. Melatonin helps reduce the waiting time before falling asleep and increases the total sleep time, improving overall sleep quality.

9. Improve secondary insomnia

In addition to primary factors, insomnia also has secondary factors, usually caused by disease, neurological, environmental, drug or psychiatric causes. Secondary factors are also very common.

Causes of disease include pain, thyroid disease, acid reflux, coronary artery disease, lung disease (chronic obstructive pulmonary disease, asthma, sleep apnea, central alveolar hypoxia syndrome), chronic renal insufficiency, eating disorders, thyroid dysfunction , fibromyalgia, menstrual-related sleep disorders, and pregnancy. Neurological causes include headaches, Parkinson's disease, and more. Environmental factors include excessive noise, harmful odors, bright lights or extreme ambient temperatures, while drug and psychiatric factors include alcoholism, anxiety disorders, mood disorders, panic disorders and other mental illnesses. Exogenous melatonin reduces the time required to fall asleep and increases total sleep time, but has no significant effect on sleep efficiency.

10. Improve fatty liver

High-dose melatonin supplementation (daily doses ranging from 6 to 18 mg, trial periods ranging from 4 to 56 weeks) helps reduce aspartate alaninase (AST), alkaline phosphatase (ALP), and gamma -Glutamyltransferase (GGT).

11． Helpful in adjusting jet lag

Jet lag, also known as circadian rhythm imbalance, is a sleep disorder caused by rapid travel through multiple time zones, causing a mismatch between the body's natural circadian rhythm and the external environment. Oral melatonin (in doses between 500mcg and 5mg) can help prevent or reduce jet lag and appears to be safe when taken occasionally for short periods of time.

12． Improve Alzheimer's disease

Alzheimer's disease is the most common cause of dementia in the elderly. Typical features are progressive decline in memory, language, and intelligence. In addition, sleep and circadian rhythm disorders are common in Alzheimer's disease (especially in the early stages of the disease), and it has been reported that up to 45% of patients may have sleep problems. Studies have shown that melatonin treatment can increase total sleep time at night, but has no significant effect on improving cognitive performance.

Suitable groups for bulk melatonin powder

01elderly

Melatonin is a natural sleeping substance produced by the human body. The reduction of melatonin is the crux of insomnia.

Supplementing melatonin can restore melatonin levels to a youthful state, while repairing the natural pattern of the human body's sleep nerves. It can shorten the time to wake up before bed and the time to fall asleep, regulate rhythm, improve sleep quality, and significantly reduce the number of awakenings during sleep. The light sleep stage is short and the deep sleep stage is prolonged.

02People with poor sleep quality

Melatonin can shorten the time to wake up before bed and the time to fall asleep, significantly reduce the number of awakenings during sleep, shorten the light sleep stage, and extend the deep sleep stage, thereby improving sleep quality.

03 People suffering from jet lag and working shifts

The secretion of melatonin in the human body has a circadian rhythm, with more melatonin being secreted at night.

Melatonin can reset the body's biological clock, adjust jet lag, correct jet lag, help reverse jet lag, and improve the sleep of shift workers.

How melatonin works

Sleep is an important guarantee for human health. Humans typically sleep only once a day periodically due to tightly controlled circadian rhythms, in which neurons, neurotransmitters, hormones, and genetic factors regulate sleep propensity, including adenosine, serotonin, and melatonin, among others.

Melatonin, also known as the sleep hormone, is a core part of the body's sleep-wake cycle. Its production increases with darkness, promotes healthy sleep, and helps adjust the body's circadian rhythm. It acts on MT1, MT2, and MT3 receptors in the body. Among them, MT1 and MT2 receptors are responsible for regulating circadian rhythm and sleep, that is, helping to promote sleep.

Test report on melatonin powder

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