Bulk Gamma aminobutyric acid powder

What is Gamma aminobutyric acid?

Bulk Gamma aminobutyric acid powder is widely distributed in animals and plants. Gamma-aminobutyric acid is contained in the seeds, rhizomes and tissue fluid of plants such as legumes, ginseng, and Chinese herbal medicines. In animals, GABA exists almost exclusively in nervous tissue, with the content in brain tissue being approximately 0.1-0.6mg/g tissue. Immunological studies have shown that the area with the highest concentration is the substantia nigra in the brain. γ-Aminobutyric acid is an important inhibitory neurotransmitter that has been extensively studied at present. It participates in a variety of metabolic activities and has high physiological activity.

Gamma-aminobutyric acid (GABA), as a neurotransmitter, can also be produced by pancreatic beta cells and regulates the function of local islet cells. Recent studies have shown that GABA can improve β-cell function and promote β-cell regeneration by inhibiting immune and inflammatory responses, inhibiting β-cell apoptosis, promoting β-cell proliferation, and inducing the transformation of pancreatic islet α-cells into β-cells. , increase insulin secretion and lower blood sugar. GABAA and GABAB receptor subtypes may be involved in mediating the beneficial effects of GABA on pancreatic islet cells. GABA and its receptor subtype agonists may be promising as a potential new strategy for the treatment of diabetes. This article reviews the role of GABA in protecting β-cell function and promoting β-cell regeneration and its potential mechanisms.

Bulk GABA powder is a non-protein natural amino acid that is widely found in animals and plants and has natural biological activity. In mammals, GABA is an important inhibitory neurotransmitter with various biological functions such as anti-anxiety, anti-fatigue, analgesia, and blood pressure reduction. Different biological functions may be caused by different GABA receptor subtypes. mediated. There are three main subtypes of GABA receptors: GABAA, GABAB, and GABAC receptors. Research in recent years has shown that GABA also plays an important role outside the nervous system. Pancreatic islet β cells themselves can also synthesize and secrete GABA, and regulate the secretion of various hormones in the islet in a paracrine and autocrine manner to maintain the homeostasis of pancreatic islet function. In addition, exogenous GABA has the effect of lowering blood sugar and promoting β-cell regeneration. Therefore, agonists of GABA and its receptor subtypes are expected to become potential new strategies for the treatment of diabetes. This article focuses on reviewing the role of GABA in protecting β-cell function and promoting β-cell regeneration and its potential mechanisms.

Source distribution

Gamma-aminobutyric acid (GABA) is a natural active ingredient widely distributed in animals and plants. Gamma-aminobutyric acid is contained in the seeds, rhizomes and tissue fluid of plants such as legumes, ginseng, and Chinese herbal medicines. In C animals, γ-aminobutyric acid exists almost exclusively in neural tissue, and the content in brain tissue is approximately 0.1 to 0.6 mg/g tissue. Immunological studies have shown that the area with the highest concentration is the substantia nigra in the brain.

What are the benefits?

1. γ-Aminobutyric acid is an inhibitory transmitter in the central nervous system. It is one of the most important neurotransmitters in biological brain tissue. Its function is to reduce neuron activity and prevent nerve cells from overheating. It can bind to and activate anti-anxiety brain receptors, and then work synergistically with other substances to prevent anxiety-related information from reaching the brain instruction center. Therefore, γ-aminobutyric acid can fundamentally calm the nerves, thus Have an anti-anxiety effect.

2. Relieve emotions

Studies have found that GABA concentrations in the plasma and cerebrospinal fluid of patients with affective disorders, depression, and alcoholic depression are reduced; in animal experiments, GABA can exert an anti-anxiety effect by regulating the nitric oxide content in the frontal cortex of anxious rats. . GABA can bind to anti-anxiety brain receptors and activate them, and then synergizes with other substances to prevent anxiety-related information from reaching the brain instruction center, fundamentally calming nerves and playing an anti-anxiety effect. GABA exerts an anti-anxiety effect by regulating nitric oxide content in the frontal cortex of anxious rats. Current research has confirmed that restoring GABA function plays a certain role in antidepressant treatment, so the GABA system may become a future treatment target for bipolar disorder.

3. Improve sleep

GABA has always been considered to be related to sleep. Numerous animal experiments and human experiments have confirmed the important role of GABA in improving subjects' sleep. Existing studies have proven that γ-aminobutyric acid can shorten the time to fall asleep and prolong slow-wave sleep II. period and rapid eye movement sleep. At the same time, the sedative and sleep-promoting effects of some drugs are due to their ability to increase the affinity of GABA receptors to strengthen the binding of GABA to the recognition site; there are also some drugs that can inhibit the decomposition of GABA to increase its content in the brain. Increase slow wave sleep time to a certain extent. Observations on the efficacy of GABA in the treatment of nocturnal cry syndrome in infants and young children have found that the effective rate is 87.5%; studies have also found that ingesting GABA can increase the activity of glucose phospholipase, thus promoting the energy metabolism of the animal brain, activating cerebral blood flow, and increasing oxygen supply. amount, ultimately restoring brain cell function and improving neurological function.

4. Regulate blood pressure

As an important inhibitory transmitter in the brain, GABA plays an important role in regulating cardiovascular activity in mammals. In a large number of animal experiments, GABA can reduce blood pressure and bradycardia. GABA can effectively promote blood vessel dilation, increase blood flow, increase oxygen supply, promote metabolism, thereby lowering blood pressure. Patients with hypertension often have reduced kidney function, and GABA has an activation effect on kidney function. Due to the activation of diuresis, excess salt can be excreted from the urine and blood pressure can be lowered.

5. Antitussive effect

In addition to its role as a transmitter, GABA can also be used as a regulator to regulate the function of the autonomic nervous system. In non-nervous tissues, it can play the role of a hormone or nutritional factor. More and more studies have shown that GABA plays an important role in the respiratory system. It is a modulator of cholinergic parasympathetic nerves and tachykinin-containing sensory nerves. It is involved in regulating allergic reactions in the airways and can inhibit nerve-induced cholinergic nerves. It has a strong antitussive effect on airway smooth muscle contraction, capillary leakage and other problems mediated by tachykinin.

6. Effects on reproduction

Bulk GABA powder can participate in the regulation of anterior pituitary hormone secretion at the hypothalamus and pituitary levels, thereby indirectly affecting the ovarian and fallopian tube functions of women. GABA also exists in the male gonads and accessory sexual organs, and is closely related to sperm movement and steroid hormone production. The presence of GABA receptors on the surface of sperm membranes suggests that GABA has a certain relationship with sperm function. GABA can induce acrosome reaction (AR) in human capacitated sperm, which increases significantly with the process of sperm capacitation, and there is an obvious dose-effect relationship. Some studies believe that in order to improve the success rate of artificial insemination, high-quality sperm must be obtained in vitro, and GABA can be used as an additive component.

7.Bulk Gamma aminobutyric acid powder is a strong neuroinhibitory amino acid and has physiological effects of sedation, hypnosis, anticonvulsance, and lowering blood pressure. It is an inhibitory neurotransmitter (InhibitoryNeurotransmitter), which can inhibit animal activities and reduce energy consumption. GABA acts on the γ-aminobutyric acid receptor in animal cells. The γ-aminobutyric acid receptor is a chloride ion channel. The inhibitory or excitatory properties of γ-aminobutyric acid depend on the chloride ion concentration inside and outside the cell membrane. After the γ-aminobutyric acid receptor is activated, it causes the opening of chloride ion channels, which can increase the permeability of the cell membrane to chloride ions, allowing chloride ions to flow into the nerve cells, causing hyperpolarization of the cell membrane and inhibiting the activation of nerve cells, thus Reduce the animal’s amount of exercise.

Addition of dosage allowed

Although the European Food Safety Authority (EFSA) allows the addition of GABA to food and stipulates that the upper limit of dietary intake of GABA is 550mg/d, its main functional properties still need to be supported by strict population test results. The U.S. Food and Drug Administration (FDA) has stated that GABA is safe to be added to food based on toxicology test results. The scope of use includes beverages, coffee, tea and chewing gum, but it is not allowed to be added to baby food, meat products or meat-containing products. . Announcement No. 12, 2009 of the Chinese Ministry of Health states that the intake of GABA shall not exceed 500mg/d, and its use scope is beverages, cocoa products, chocolate and beverages, candies, baked goods and puffed foods, but it cannot be added to baby food.

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