What Is The Genistein?
What Is The Genistein?
Genistein is insoluble in water, soluble in ethanol and DMSO. It is a pale yellow powder with a melting point of 297-298°C. It is a powerful antioxidant. It protects deoxyribonucleic acid (DNA) from oxidative damage and mutation.
Genistein, also known as genistein, genistein, 5, 7, 4-trihydroxy isoflavone, is mainly extracted from soybeans, clover, Sophora japonica, Sophora japonica, and genistein plants. It is an active ingredient known as phytoestrogen.
It is a type of flavonoid (also called isoflavone). Genistein is often found with isoflavones called daidzein, both of which are called soy isoflavones, which are weak estrogen-like and non-estrogenic compounds.
Genistein is a naturally occurring compound with a variety of biological activities, including antioxidant, anti-inflammatory, antibacterial, and antiviral. Therefore, it is widely used in various health products and dietary supplements. Genistein is also a tyrosine kinase inhibitor, which works by blocking the transmission of biological signals from receptors on the cell's surface to the cell itself. These receptors on the cell's surface tell the cell what it is currently surrounded by and are also responsible for communicating with other cells in the vicinity.
Genistein is a potent isoflavone found in a variety of plant foods. When the compound occurs as a glycoside, it is sometimes called genistein and is commonly found in soybeans and other legumes. The exploration of alternative names for genistein highlights its diversity in nature and its importance in traditional medicine and scientific research.
Plant Extract Sources
Genista tinctoria Linn.
Sophora subprostrala Chunet T.Chen root
Sophora japonica fruit
Trifolium pratense whole herb
Benefits of the product
Antioxidant
Genistein can clear the generation of free radicals in the body, relieve oxidation, and play an antioxidant role. It helps to reduce aging and pathological changes caused by free radical damage. In addition, genistein can also maintain human cardiovascular health, promote blood lipid metabolism, effectively avoid lipid oxidation in blood lipids, and also has the effect of softening blood vessels.
Anti-inflammatory and antibacterial
Genistein is a chemical substance that also has certain medicinal value. It can play an antibacterial and anti-inflammatory role in wound treatment. Genistein is a natural plant that has a very similar structure to estrogen, so it can prevent menopausal syndrome. It also has anti-inflammatory and analgesic effects.
Prevent osteoporosis
Genistein also has a preventive effect on osteoporosis. After application, it can promote the growth and differentiation of bone cells, help bone formation, and effectively inhibit the proliferation and differentiation of osteoclasts, as well as the function of bone resorption.
Protect brain function
It can affect the brain morphology and structure through the blood-brain barrier, improve brain function and avoid Alzheimer's disease.
Calming and soothing the nerves
Genistein also contains soy isoflavones, which can relieve the symptoms of poor sleep and have a calming and soothing effect. It can improve mood swings, calm the nerves, and improve symptoms such as insomnia and headaches caused by mood swings.
Supplement hormones
Genin contains soy isoflavones, and the aglycone form of soy isoflavones is more active than the glycoside form, especially GEN, which has a bidirectional regulatory effect on phytoestrogens. It can alleviate the symptoms of reduced hormone content in the body and play a supplementary effect.
Genin, as a currently recognized natural phytoestrogen, has a similar structure to estrogen and has a preventive and therapeutic effect on menopausal symptoms.
GEN can penetrate and rewrite the expression of estrogen-regulated genes like estrogen, suggesting that GEN binds to estrogen receptors. In addition to producing anti-estrogen-like effects, it can also activate estrogen response elements and show certain estrogen effects.
Genistein and anti-radiation effect
Genistein is an effective inhibitor of protein tyrosine kinase activity, and also has antioxidant and estrogen-like effects. Genistein has anti-radiation effects and is used in the prevention and treatment of side effects of tumor radiotherapy. Taking genistein before irradiation of traumatic brain injury can also reduce lung damage in long-term surviving animals.
Effects of genistein on the cardiovascular system
Genistein, a phytoestrogen, has a variety of positive effects on the cardiovascular system.
Genistein plays a cardiovascular protective role in preventing and treating atherosclerosis, myocardial protection, anti-arrhythmia, regulating blood pressure and other cardiovascular mechanisms by regulating lipid metabolism, antioxidant, vascular protection and anti-inflammation.
It has a protective effect on acute myocardial ischemia and hypoxic injury, and has a protective effect on myocardial cells by improving cardiac electrical function and resisting oxidative stress damage. It can reduce the levels of lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) in myocardial tissue, and increase the activity of superoxide dismutase (SOD), thereby reducing oxidative stress damage.
It has a similar structure to estrogen and can competitively bind to estrogen receptors to exert estrogen-like effects. Its functions in the cardiovascular system include regulating lipid metabolism, antioxidant, anti-tumor, anti-diabetic, etc. Specific to the cardiovascular system, genistein can improve bone density and uterine quality, has a significant anti-osteoporotic effect on osteoporosis rats, and can reduce the total cholesterol and liver cholesterol levels in ovariectomized rats.
Genistein also has anti-arrhythmic, myocardial protection, and anti-atherosclerotic effects. The mechanism may be related to the binding of genistein to estrogen receptors, which can protect the cardiovascular system through anti-inflammatory and antioxidant effects.
What is Genistein used for?
Genistein is gradually being valued as a natural and environmentally friendly dye. At present, genistein has been widely used in food, cosmetics and other fields, and has gradually become a sustainable production method.
Applied in the field of medicine, it can be made into suppositories, lotions, injections, tablets, capsules, etc.
Applied in the field of health care products, it can be used in health care products such as women's beauty care products and prevention of blood diseases.
Due to its antioxidant properties, Gen can be selected as a food additive to play its dual role.
Estrogen-like value addition is very sensitive, simple and easy to distinguish agonists and antagonists, so it is widely used in the rapid screening and evaluation of environmental estrogens and phytoestrogens.
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