What is osthole?

What is osthole?

Osthole, also known as oleanolic acid methyl ether or 7-methoxy-8-isopentenylcoumarin, is a natural coumarin compound. It is mainly found in the dried and mature fruits of the Apiaceae plant Cnidium monnieri. Osthole has a variety of pharmacological activities, including antispasmodic, antihypertensive, antiarrhythmic, immune-enhancing and broad-spectrum antibacterial effects. In addition, osthole is used in the medical field to treat gynecological diseases and dermatological problems, such as kidney yang deficiency, cold and dampness invasion of waist and knee pain, etc.

What are the effects of osthole?

Warm the kidneys and strengthen yang

Osthole has the effect of warming the kidneys and aphrodisiac, can enhance kidney function, increase sex hormone levels, and has a therapeutic effect on male and female infertility. Clinically, it is often used to treat symptoms such as male impotence, premature ejaculation, and spermatorrhea, as well as female symptoms such as cold uterine infertility and increased leucorrhea.

Dispelling wind and relieving itching

Osthole has the effect of dispelling wind and relieving itching, and can relieve symptoms of skin diseases such as skin itching, eczema, and scabies. The method of fumigating with water or grinding into powder and spreading for application before external use has a significant effect on improving skin problems.

Anti-inflammatory

Osthole has certain anti-inflammatory effects and can relieve pain and discomfort caused by inflammation. Clinically, it is often used to treat inflammatory diseases such as frozen shoulder, rheumatoid arthritis, and osteoarthritis.

Antioxidant

Osthole also has strong antioxidant capacity, which can scavenge free radicals in the body, slow down the aging process of the skin, and improve the elasticity and gloss of the skin. At the same time, it can also improve blood circulation and promote good health.

Anti-allergic

Cnidol can treat allergic diseases such as eczema, prurigo, urticaria, etc. However, it should be noted that the syndrome differentiation of these skin diseases is mostly based on blood heat and damp heat.

Lower blood pressure and improve heart rhythm imbalance

In clinical trials, osthole has been shown to help improve spasms, address high blood pressure, combat heart rhythm imbalances, and enhance the body's own immunity. In addition, it has a positive effect in fighting bacteria.

Warm the kidneys and strengthen yang

Cnidol helps improve impotence, premature ejaculation and other problems caused by kidney yang deficiency, and can be used equally with epimedium and antler tablets. For female sexual dysfunction and infertility problems, it can also be used with Morinda officinalis and Eucommia ulmoides.

Improve uterine cold and other sexual problems

For male and female sexual function problems, osthole can be used to treat impotence, uterine cold infertility, etc. In addition, it can also help solve problems such as vulvar itching and trichomonas vaginitis in women.

Effects of osthole on the immune system

Enhanced phagocytic function: It can enhance the phagocytic function of mouse reticuloendothelial cells. Continuous intraperitoneal administration of osthole can significantly increase the carbon particle clearance index and phagocytosis index, indicating that it has an immune-enhancing effect.

Inhibiting hypersensitivity reactions: Osthole has a significant inhibitory effect on delayed hypersensitivity reactions in mice, suggesting that it may play a role in regulating immune responses.

Effect on serum hemolysin content: The effect of osthole on serum hemolysin content in mice was not significantly different from that of the control group, indicating that it may not significantly change the level of antibody production.

Enhance specific immune function: It has the ability to enhance the specific response of the immune system, which may be related to its ability to cause increased activity of host resistance-related enzymes.

Disease prevention mechanism: Osthole can induce an increase in the host's disease resistance and up-regulate the transcription level of the chitinase gene in the leaves. It may exert its immunoregulatory effect by improving the host's disease resistance.

What effects does osthole have on the skin?

Insecticide, antipruritic and anti-dampness: Osthole has a good effect on treating eczema caused by viral and fungal infections.

Anti-inflammatory and anti-allergic: Osthole has anti-inflammatory and anti-allergic effects, which helps reduce skin inflammation and itching.

Moisturizing and care effects: In vitro tests show that osthole has good hygroscopicity and moisturizing properties, and has a care effect on the skin.

Whitening and spot removal: Whitening products containing osthole extract can effectively inhibit skin flushing and have a high-efficiency whitening effect, which helps to improve uneven skin tone and dullness.

Sedative effect: Osthole has shown central sedative effects in pharmacological studies, which may help relieve discomfort caused by skin problems.

Antibacterial effect: It has a broad-spectrum antibacterial effect and may have a certain inhibitory effect on bacterial infections on the skin.

In which fields is osthole used

Medical field

Osthole is mainly used in the medical field to prevent and treat gout. The target of osthole is to inhibit xanthine oxidase, reduce the formation of urate, and has a strong anti-inflammatory and analgesic effect. It can be prepared into different pharmaceutical dosage forms, such as tablets, capsules, granules, injections and suspensions.

Cosmetic field

Osthole is an ingredient widely used in the cosmetic field. It is mainly derived from the dried mature fruit of the Umbelliferae plant cnidium, and its chemical name is 7-methoxy-8-isopentenylcoumarin. Osthole is widely used in anti-allergic cosmetics because of its anti-allergic, anti-allergic and strong anti-histamine effects. Specifically, osthole can be added to various types of skin care products such as essences, facial masks, lotions, creams, lotions, skin care gels, etc., for acne and inflammation, and has an inhibitory effect on the formation of various inflammatory factors, thus having a good therapeutic effect on facial acne and pimples

Agricultural field

Osthole is mainly used for insecticide and sterilization in the agricultural field. It has a good control effect on a variety of lepidopteran pests and homoptera pests, and can prevent and control vegetable powdery mildew, downy mildew and other diseases. Osthole is a highly efficient and low-toxic biological pesticide with no residue and is environmentally friendly.

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