What Is Hesperidin? Benefits And Uses You Need To Know

Ⅰ、Introduction to Hesperidin

Hesperidin is a natural plant compound that belongs to the flavonoid class. It is widely found in the peels of citrus fruits such as orange peel, pomelo peel, and lemon peel. Hesperidin has strong antioxidant, anti-inflammatory, antibacterial, antiviral and other biological activities, so it is widely used in medicine, health products, cosmetics and other fields. Hesperetin is one of the active ingredients of orange peel. It has been proven that its structure is a phenolic compound. Its properties are colorless crystals or crystalline powders with an aromatic smell. The melting point is 50℃~51℃ and the boiling point is 232℃. It is easy to volatilize and difficult to Soluble in water, easily soluble in organic solvents such as ethanol and ether, it has a good effect on treating animal mites.Compared with organic phosphorus, organic nitrogen, and organic chlorine, it has the advantages of less toxic side effects, low residue, and no environmental pollution. For clinical treatment, it has the disadvantages of high cost and difficulty in making easy-to-use preparations. Tangeretin is widely used in Chemicalbook organic chemistry and life sciences and other fields. Because the content of tangeretin in plants is low and it is expensive, research on tangeretin in my country lags behind. my country is rich in citrus resources and has broad prospects for the extraction and application of tangeretin.

Ⅱ、Extraction method of Hesperidin

Hesperidin is mainly extracted from plants of the Rutaceae or Euphorbiaceae families. The extraction methods include recrystallization, column chromatography, high-speed countercurrent chromatography and carbon dioxide supercritical extraction. Recrystallization method: Dancy orange is a famous citrus variety native to the United States. Research has found that cold-pressed orange oil made from Danxi oranges formed a yellow precipitate after centrifugation and long-term freezing. Limonene was further removed and recrystallized to obtain white crystalline tangeretin. Tangeretin is co-produced with cold-pressed tangerine oil as a by-product, which can greatly reduce its production cost. Column chromatography: Column chromatography uses gradient elution with mixed organic solvents to extract tangeretin from plants such as sweet orange, Citrus aurantium, Danxi orange and Croton hairy leaf. High-speed counter-current chromatography: High-speed counter-current chromatography, (HSCCC for short) is a liquid-liquid distribution chromatography technology. Compared with other chromatographic separation methods, HSCCC does not use any solid Chemicalbook carrier or support as a stationary phase. The sample only achieves efficient separation and preparation of pure products in a short time through the distribution difference between two-phase immiscible solvents. In recent years, It has received attention and application in the field of extracting natural products. Carbon dioxide supercritical extraction method: Supercritical carbon dioxide has a special dissolving effect on certain natural products. The principle of carbon dioxide supercritical extraction technology is to use the relationship between the solubility of supercritical carbon dioxide and its density, that is, to use pressure and temperature to determine the solubility of supercritical carbon dioxide. The influence of extraction. In the supercritical state, supercritical carbon dioxide is brought into contact with the substances to be separated, so that components of different polarities, boiling points and molecular weights can be selectively extracted in sequence, and then the supercritical fluid can be transformed into ordinary fluids by reducing pressure, increasing temperature, etc. The gas and the extracted substance are completely or basically precipitated, thereby achieving the purpose of separation and purification.

Ⅲ、The role of Hesperidin

1. Antioxidant effect

Tangerine has a strong antioxidant effect, can scavenge free radicals, reduce oxidative stress reactions, and protect cells from oxidative damage. Research shows that tangeretin can reduce the risk of cardiovascular disease, cancer and other diseases and delay the aging process.

2. Anti-inflammatory effect

Hesperidin can inhibit inflammatory response and reduce inflammatory symptoms. Research shows that tangeretin can reduce the expression of inflammatory factors, inhibit the activation of inflammatory cells, and reduce the release of inflammatory mediators.

3. Antibacterial effect

Hesperidin has a strong antibacterial effect and can inhibit the growth and reproduction of a variety of bacteria. Research shows that tangeretin can inhibit the growth of Staphylococcus aureus, Escherichia coli, Streptococcus and other pathogenic bacteria.

4. Antiviral effect

Tangerine can inhibit the growth and reproduction of a variety of viruses, including influenza virus, hepatitis B virus, etc. Research shows that tangeretin can interfere with the replication process of the virus and reduce the risk of viral infection.

Ⅳ、The effect of tangeretin

1. Lower blood lipids

Hesperetin can reduce serum total cholesterol, triglycerides and low-density lipoprotein cholesterol levels and increase high-density lipoprotein cholesterol levels, thereby reducing the risk of cardiovascular disease.

2. Anti-cancer

Tangerine can inhibit the growth and reproduction of cancer cells and promote the apoptosis of tumor cells, thus having anti-cancer effects. Studies have shown that tangeretin has significant inhibitory effects on various cancers such as colorectal cancer, lung cancer, and breast cancer.

3. Protect the liver

Tangerine can reduce liver damage and promote the regeneration and repair of liver cells, thereby protecting the liver. Studies have shown that tangeretin can reduce the oxidative stress response of the liver and reduce the degree of liver damage.

4. Anti-diabetic

Hesperetin has anti-diabetic properties by lowering blood sugar levels and improving insulin sensitivity. Research shows that tangeretin can reduce the absorption and utilization of glucose and promote the secretion and utilization of insulin.

Ⅴ、Application of Hesperidin

1.Pharmaceutical field

Hesperetin is widely used in the medical field as an auxiliary therapeutic drug for various diseases such as antioxidant, anti-inflammatory, antibacterial, and antiviral. For example, tangeretin can reduce the risk of cardiovascular disease, cancer, diabetes and other diseases and promote patient recovery.

2. Health care products field

Hesperetin is widely used in the field of health care products as the main component of health care products. For example, tangeretin can delay aging, improve immunity, promote sleep, etc., and has become one of the commonly used health products for modern people.

3. Cosmetics field

Hesperetin is widely used in the field of cosmetics as the main ingredient of cosmetics. For example, tangeretin has multiple effects such as antioxidant, anti-inflammatory, antibacterial, and antiviral, and has become one of the important ingredients in cosmetics.

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