What is genistein powder?

What is genistein powder?

Genistein, also known as genistein, is a polyphenolic compound found in soybeans and other plants such as red clover. It is a type of flavonoid. Genistein has low solubility in water but high solubility in DMSO and ethanol. It is mainly an active ingredient extracted from leguminous plants such as soybeans, clover, kudzu root, sophora japonica,  broad bean root. It is called phytoestrogen and can play a variety of biological functions in cells. Many studies have shown that it can relieve inflammation, change intestinal flora, and improve epithelial barrier function in several animal models of intestinal diseases.

What are the functions of genistein?

Antibacterial and anti-inflammatory: It has certain antibacterial and anti-inflammatory effects, and has obvious inhibitory effects on some pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Acinetobacter baumannii.

Sedative and tranquilizing: It can improve mood swings, has a calming and tranquilizing effect, and can improve symptoms such as insomnia and headaches caused by mood swings.

Antioxidant: It can effectively inhibit the generation of free radicals and lipid peroxidation, relieve diseases caused by oxidation, and has a good antioxidant effect.

Anti-thrombotic: It has a certain anti-thrombotic effect and helps to improve cardiovascular diseases such as hypertension, angina pectoris, and coronary atherosclerotic heart disease.

Anti-osteoporosis: As a "phytoestrogen", it can promote the proliferation and differentiation of osteoblasts and inhibit the bone resorption of osteoclasts, thereby playing an anti-osteoporosis role.

Anti-aging: Studies have shown that it can prolong the lifespan of mice, relieve age-related weakness, improve intestinal dysfunction, and enhance the health of intestinal microbiota, thereby delaying the aging process.

How genistein delays aging

Improve intestinal health: It can increase the level of short-chain fatty acids derived from the flora and regulate the balance of the aged intestine, thereby improving age-related intestinal dysfunction. Studies have shown that it increases the expression of MUC2 in the colon of aged mice, accelerates intestinal epithelial regeneration, and increases the number of proliferating cells, thereby improving intestinal function.

Enhance immune function: It inhibits the expression of pro-inflammatory cytokines in the colon tissue of aged mice and enhances the expression of anti-inflammatory cytokines, thereby alleviating age-related weakness. In vitro studies have shown that propionic acid, which is related to it, can enhance the function of colonic Treg cells and further reduce the level of inflammation in aged mice.

Extend lifespan: Studies have shown that mice fed it have improved survival rates, increased median lifespan, maximum lifespan, and average lifespan. Genistein in the diet can significantly extend the lifespan of aged mice and improve their overall health.

Preparation process

1.Chemical synthesis method

Chemical synthesis method usually involves the use of specific chemical reactions for synthesis. For example, it can be synthesized through steps such as catalytic hydrogenation, redox reaction, polymerization reaction, etc. These methods usually require a high level of technology and complex equipment.

2. Plant extraction method

Plant extraction method is a more environmentally friendly and sustainable method, which is obtained by extracting natural products from plants. This method includes steps such as ethanol extraction, acid hydrolysis, and chloroform extraction. For example, it can be extracted from plants such as Sophora japonica.

3. Microbial synthesis method

Microbial synthesis method uses the metabolic pathways of microorganisms for production. This method involves the construction of a specific microbial expression system so that exogenous genes can be expressed in microorganisms to synthesize it. For example, the research team of Tianjin University achieved the synthesis of it from glucose and glycerol by constructing an Escherichia coli co-culture system.

4. Bioengineering technology

Bioengineering technology can be used to optimize the production efficiency and yield of genistein. For example, the genetic characteristics of plants or microorganisms can be improved through genetic engineering technology to improve the synthesis efficiency and yield.

Application areas

Food: As a natural dye, it is harmless and environmentally friendly and is widely used in the food field. For example, it can be used in solid beverages, compressed candies, food and health products, etc.

Cosmetics: Its application in cosmetics is also increasing. Due to its natural and harmless characteristics, it is suitable for coloring and functional additives in various cosmetics.

Feed additives: Studies have shown that it can be used as a green feed additive to replace antibiotics in young laying hens, which helps to strengthen the bones of laying hens and the quality of eggs.

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