What does ursolic do?

What does ursolic do?

Ursolic acid, also known as ursolic acid and ursolic acid, is a natural triterpenoid compound that is widely used in nature and can be extracted and separated from various medicinal plants and fruits. It has a variety of biological effects such as sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar.

It is a compound naturally present in loquat leaves and rosemary leaves. These two plants have long been widely used in herbal medicine and cooking, and ursolic acid is a precious treasure among them. By extracting the leaves of these plants, we can get natural extracts, bringing a gift from nature to human health. It can also be found in many fruits and plants, such as apples, basil, bilberry, cranberry, elderberry, mint, rosemary, lavender, oregano, thyme, hawthorn and prune. It is used in cosmetics and personal care products because of its anti-aging and anti-inflammatory properties. It has anti-inflammatory, antimicrobial, antibacterial and antifungal properties, which can not only prevent the growth of bacteria and fungi in skin and skin care products, but also help wound healing. It is known to prevent the formation of cyclooxygenase and lipoxygenase, enzymes that aggravate skin inflammation.

What functions does it have?

Strong antioxidant capacity

It can absorb ultraviolet rays to prevent pigmentation caused by ultraviolet radiation. It has strong antioxidant effect and free radical scavenging ability, reduces the damage of oxidative stress to cells, and has positive effects on human anti-aging, skin freckle removal and pigment removal.

Inhibit melanin production

It can inhibit the activity of tyrosinase, inhibit melanin production, maintain the physiological activity of epidermal cells and promote cell metabolism, and play a comprehensive role in skin nutrition and skin whitening.

Repair skin barrier

By increasing the ceramide content of human epidermal keratinocytes and the collagen content of epidermal fibroblasts, it improves the skin barrier function and revitalizes the skin.

Anti-inflammatory

It can inhibit the generation and release of inflammatory mediators, reduce inflammatory reactions, and has auxiliary therapeutic effects on various inflammatory diseases such as arthritis and skin inflammation.

Antibacterial and antiviral

It has an inhibitory effect on a variety of pathogenic bacteria and viruses, and can be used to prevent and assist in the treatment of infectious diseases.

Liver protection

It can protect liver cells, reduce liver damage, and promote liver cell regeneration through antioxidant and anti-inflammatory effects, which is helpful for the prevention and treatment of chronic liver disease.

Lowering blood lipids and blood sugar

It can regulate lipid metabolism, reduce cholesterol and triglyceride levels in the blood, improve insulin sensitivity, help control blood sugar levels, and have a preventive and auxiliary therapeutic effect on cardiovascular diseases and diabetes.

Ursolic acid inhibits mast cell degranulation and reduces TSLP by inhibiting the MRGPRX2/MrgprB2-dependent pathway

Effectively reduces itching

Inhibits MRGPRX2 receptors

By inhibiting MRGPRX2/MrgprB2 receptors, mast cell degranulation is effectively reduced, which may reduce the inflammatory response associated with itching.

Significantly inhibits the itching symptoms associated with xeroderma by reducing the production of TSLP and its effects in sensory neurons.

Dual effects of ursolic acid on multiple sclerosis via immunomodulation and direct remyelination

UA induced myelin neurotrophic factor CNTF in myelin in astrocytes via peroxisome proliferator-activated receptor gamma (PPARγ)/CREB signaling, and upregulation of myelin-related gene expression during oligodendrocyte maturation via PPARγ activation.

Oral UA effectively ameliorates acute CNS autoimmunity

UA treatment alleviates chronic EAE, promotes remyelination, and reduces axonal degeneration and neuronal dendrite destruction.

The therapeutic effects of UA on CNS autoimmunity are PPARγ-dependent.

UA enhances remyelination in cupricone-induced demyelination in a PPARγ-dependent manner.

UA enhances remyelination after demyelination in LPC organotypic cerebellar slices.

CNTF secreted by astrocytes after UA treatment enhances OPC differentiation in vitro.

UA induces astroglial CNTF production via PPARγ/CREB signaling.

UA directly induces OPC differentiation and myelin-related gene expression via PPARγ.

UA-mediated EAE immunomodulatory and neuroregenerative effect model.

What can it be used for?

Food

It can be used as a natural preservative and antioxidant for food, extending the shelf life of food and maintaining its freshness. Ursolic acid is widely used in foods such as meat products, jams, and oil products to provide protection and stability. In addition, ursolic acid can also be used as a nutritional enhancer to improve the quality and safety of food, becoming a star ingredient in healthy foods.

Cosmetics and personal care

It is used in skin care products, shampoo, shower gel and other products, giving them a unique aroma and moisturizing effect. It is also used in oral care products such as toothpaste and mouthwash to help protect oral health. Ursolic acid is mainly used for whitening, moisturizing and anti-aging in cosmetics, and has become one of the ingredients of many skin care products.

Pharmaceuticals and health products

It can be used to make traditional herbal formulas and health products, providing soothing and relaxing effects, and is often used in massage and body care products. It can inhibit inflammation and promote cell apoptosis, so it has a wide range of applications in drug development.

Agriculture

It can be used as a plant growth regulator and natural pesticide to help protect crops from pests and diseases and promote plant growth and development.

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