What does tauroursodeoxycholic acid powder do?

What does tauroursodeoxycholic acid powder do?

Tauroursodeoxycholic acid, more commonly known as TUDCA, has the chemical name 3α, 7β dihydroxycholanoyl-N-taurine. For obvious reasons, it is found in the bile that is excreted by our liver and stored in the gallbladder. It is a conjugated bile acid formed by the contraction between the carboxyl group of ursodeoxycholic acid and the amino group of taurine, and is the main bile acid in bear bile. The content of TUDCA in human bile is very small, but it accounts for about 50% of bear bile. TUDCA is a conjugated bile acid widely present in the bile of humans and various animals, and has antispasmodic, anticonvulsant, anti-inflammatory and gallstone dissolving effects.

How does tauroursodeoxycholic acid protect the liver?

Promote bile excretion and reduce bile acid reabsorption: TUDCA has a high degree of ionization and hydrophilicity, which makes it highly bioavailable in the enterohepatic circulation, helps promote bile excretion, and has little damage to cells.

Protect liver cell membranes: It has a strong choleretic and liver-protecting effect, and protects liver cell membranes from damage by antagonizing the toxic effect of liver cell membranes.

Inhibit hepatocyte apoptosis: TUDCA can inhibit hepatocyte apoptosis and necrosis induced by hydrophobic bile acids, and produce anti-apoptotic signals by activating epidermal growth factor and mitogen-activated protein kinase, thus playing an anti-apoptotic role.

Immunomodulatory effect: TUDCA can also regulate the immune system and reduce inflammatory responses, thereby protecting the liver from further damage.

Reduce hepatocyte damage: TUDCA has antioxidant and anti-inflammatory effects, which can reduce the damage of free radicals to hepatocytes, reduce inflammatory responses, and protect hepatocytes from damage.

Lowering cholesterol: TUDCA can lower cholesterol levels in the liver and blood, reduce cholesterol accumulation in the liver, and prevent the occurrence of cholesterol liver disease.

Anti-apoptotic effect: TUDCA can inhibit apoptosis of liver cells, reduce liver cell death, and help maintain the normal structure and function of the liver.

Function of tauroursodeoxycholic acid

Promote gallstone dissolution: It can change the ratio of cholesterol and bile salts in bile, making it easier to dissolve, thereby reducing the formation of gallstones and promoting the dissolution of existing gallstones.

Lowering blood lipids: TUDCA can lower serum total cholesterol levels, improve abnormal lipid metabolism, and help prevent and treat hyperlipidemia.

Anti-inflammatory effect: It has a certain antioxidant capacity, can inhibit the production of free radicals, reduce tissue damage and inflammatory response, and has a certain auxiliary effect in fighting various inflammatory diseases.

Improve digestive system function: It can promote bile secretion and gallbladder contraction, increase the pressure in the bile duct, thereby increasing bile flow, and help the normal functioning of the digestive system.

Protect the nervous system: Studies have shown that TUDCA may have the effect of protecting the nervous system, can reduce the damage of nerve cells, and has a certain potential to fight neurodegenerative diseases.

Delaying the progression of cirrhosis: It may delay the progression of cirrhosis by inhibiting the expression of TGF-β1, improve the liver function indicators of patients with cirrhosis, and especially improve the level of cholestasis indicators.

Preparation method

1) The preparation of crude tauroursodeoxycholic acid is carried out according to the following steps:

In a reactor, add 4.0KG ursodeoxycholic acid, add 19KG acetone, add 1650ml triethylamine under stirring, turn on the jacket refrigeration, and reduce the temperature of the mixed solution to -10℃. Add 1120ml ethyl chloroformate, control the addition rate of ethyl chloroformate, so that the temperature of the reaction solution is maintained between -5-0℃Chemicalbook, add it after 30 minutes, continue to maintain the temperature and stir the reaction for 40 minutes, and obtain a mixed anhydride of ursodeoxycholic acid and ethyl chloroformate. The above mixed anhydride reaction liquid is filtered through a filter with nitrogen pressure into a 50-liter reactor filled with 4.2KG purified water, 1.4KG taurine, and 0.4KG sodium hydroxide. Stir the reaction for 3 hours to further obtain 4.0KG of crude tauroursodeoxycholic acid.

2) The crude product of tauroursodeoxycholic acid is purified according to the following steps:

(1) 4.0 kg of tauroursodeoxycholic acid is put into a 50 L reactor, 4 kg of water and 580 ml of acetone are added, and the mixture is heated and stirred until it is completely dissolved;

(2) The mixture is cooled to -5-0 °C under stirring and crystallized for 30 hours;

(3) The chemical book is discharged into the filter and filtered, and the filter cake is rinsed with ice water (-3-0 °C) after being dried, and then dried again to obtain 3.3 kg of tauroursodeoxycholic acid (purity 99.6%, HPLC), of which the content of tauroursodeoxycholic acid is 0.3%, and the maximum content of other impurities is 0.05% (liquid chromatography determination).

Application fields

Medical field: TUDCA is mainly used to treat liver diseases such as gallstones, cholestatic liver disease, cirrhosis, hepatitis, etc. In addition, TUDCA is also used to treat chronic hepatitis C, alcoholic fatty liver, non-alcoholic fatty liver and other diseases.

Health care products: Because TUDCA has many health benefits such as antioxidant, anti-inflammatory, and cholesterol-lowering, it is also widely used in the field of health care products to improve liver function, promote digestion, and lower blood lipids.

Cosmetic field: Because TUDCA has antioxidant effects, it is also used in the cosmetic field to develop skin care products with anti-aging, whitening, and freckle removal effects.

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