What are the effects of oleanolic acid?
What is oleanolic acid?
Oleanolic acid is a natural pentacyclic triterpene substance with an oleanane skeleton. Its hydroxyl and carboxyl positions are similar to those on ursolic acid and betulinic acid. It exists in many plants and foods in the form of free acid or aglycone of triterpene saponins. The main extraction sources include the leaves of Oleaceae plant Olea europaea, the whole grass of Gentianaceae plant Green Leaf Gallbladder, Ligustrum lucidum fruit, Sichuan Swertia odorata, the leaves and roots of Umbelliferae plant Star Celery, the root bark and stem bark of Araliaceae plant Aralia, and the tubers of Cucurbitaceae plant Large Seed Snow Gallbladder, Lovely Snow Gallbladder, and Chinese Snow Gallbladder.
Oleanolic acid has a variety of pharmacological effects, including reducing liver damage, reducing serum alanine aminotransferase activity, reducing serum r-globulin, and is consistent with the reduction of liver-related inflammatory reactions observed by histological observations. It can also promote the regeneration of hepatocytes, reduce the level of tyrosine in brain homogenate of rats with cirrhosis, and inhibit liver fibrosis. In addition, oleanolic acid has a significant inhibitory effect on the mouse mononuclear phagocyte system, macrophage phagocytic function and experimental arthritis, and has an impact on heterosexual humoral immune function and antigen-binding cells.
What are the effects of oleanolic acid?
Antioxidant
Oleanolic acid can scavenge free radicals in the body and help reduce the damage caused by free radicals to cells, thereby protecting cell health and delaying the aging process. This antioxidant effect is beneficial to preventing skin aging and protecting cardiovascular health.
Regulate blood lipids
Oleanolic acid can promote the catabolism of fat, reduce the levels of triglycerides and low-density lipoprotein cholesterol in the blood, and prevent the occurrence of cardiovascular diseases. At the same time, it can also increase low-density lipoprotein receptor activity and help regulate blood lipid balance.
Liver protection and enzyme lowering
Oleanolic acid can protect liver cells from damage, reduce serum aminotransferase levels, and improve liver function abnormalities. It can also enhance the detoxification function of the liver, promote bile secretion and excretion, and help improve symptoms such as alcoholic liver damage.
Antibacterial and anti-inflammatory
Oleanolic acid has broad-spectrum antibacterial activity and can inhibit the growth and reproduction of a variety of bacteria and fungi, thereby reducing inflammatory responses. This property makes it effective in treating infectious diseases such as bronchitis, periodontitis, and acute tonsillitis.
Promote digestion
Oleanolic acid can promote gastric acid secretion and help digestion and absorption of food. For people with weak gastrointestinal motility and indigestion, moderate intake of oleanolic acid can help improve digestive function.
Improve skin
Oleanolic acid can promote skin metabolism and improve symptoms such as dark yellow skin and spots. At the same time, its antioxidant effect also helps reduce the damage of free radicals to the skin and achieve beauty and beauty effects.
Improve vision
Oleanolic acid can promote the production of rhodopsin in the retina, helping to improve vision and relieve visual fatigue.
Reduce liver damage
Oleanolic acid has a certain effect on reducing liver damage. Clinically, after patients with liver injury are treated with oleanolic acid, some damaged cells and tissues in the liver recover relatively well, which can reduce inflammation in the liver. Reactions are alleviated.
Effects of Oleanolic Acid on the Immune System
Lymphocyte Proliferation Effect: Oleanolic acid has a definite lymphocyte proliferation effect, which indicates that it can enhance the activity of the immune system.
Immunosuppressive Effect: In some cases, oleanolic acid also has an immunosuppressive effect, which indicates that it can be used to regulate the immune system response.
Anti-inflammatory Effect: Oleanolic acid has anti-inflammatory effects, which are related to the regulation of the immune system because it can reduce inflammatory responses, which is an important function in the treatment of immune system diseases.
How does oleanolic acid improve skin?
Antioxidant
Oleanolic acid can scavenge free radicals in the body and help reduce the damage caused by free radicals to cells, thereby protecting cell health and delaying the aging process. This antioxidant effect is beneficial to preventing skin aging and protecting cardiovascular health.
Liver protection and enzyme lowering
Oleanolic acid can protect liver cells from damage, reduce serum aminotransferase levels, and improve liver function abnormalities. It can also enhance the detoxification function of the liver, promote bile secretion and excretion, and help improve symptoms such as alcoholic liver damage.
Antibacterial and anti-inflammatory
Oleanolic acid has broad-spectrum antibacterial activity and can inhibit the growth and reproduction of a variety of bacteria and fungi, thereby reducing inflammatory responses. This property makes it effective in treating infectious diseases such as bronchitis, periodontitis, and acute tonsillitis.
Promote digestion
Oleanolic acid can promote gastric acid secretion and help digestion and absorption of food. For people with weak gastrointestinal motility and indigestion, moderate intake of oleanolic acid can help improve digestive function.
Improve skin
Oleanolic acid can promote skin metabolism and improve symptoms such as dark yellow skin and spots. At the same time, its antioxidant effect also helps reduce the damage of free radicals to the skin and achieve beauty and beauty effects.
Improve vision
Oleanolic acid can promote the production of rhodopsin in the retina, helping to improve vision and relieve visual fatigue.
Protective effect of oleanolic acid on cardiovascular disease
Protection against myocardial ischemia-reperfusion injury
Oleanolic acid can reduce the area of myocardial ischemia-reperfusion injury and improve myocardial function. Its protective mechanism may be related to inhibiting the production of oxygen free radicals, reducing calcium ion overload, and improving energy metabolism. In addition, oleanolic acid can inhibit myocardial cell apoptosis and reduce myocardial damage.
Inhibition of atherosclerosis
Oleanolic acid can reduce the levels of serum total cholesterol, low-density lipoprotein cholesterol and triglycerides, and increase the level of high-density lipoprotein cholesterol. It can also inhibit the synthesis and absorption of cholesterol and promote the excretion of cholesterol, thereby improving lipid metabolism and reducing the occurrence of atherosclerosis.
Inhibition of hypertension
It can lower blood pressure, and its mechanism may be related to inhibiting the renin-angiotensin-aldosterone system, dilating blood vessels, and increasing urinary sodium excretion. Its therapeutic effect is similar to that of some conventional antihypertensive drugs, but with fewer side effects.
Improvement of heart failure
Oleanolic acid can improve the cardiac function of patients with heart failure, improve their exercise tolerance and quality of life.
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