The Top 5 Benefits Of Pterostilbene For Brain Health And Function
What is pterostilbene？
Pterostilbene, Pterostilbene is a chemical component contained in Pterostilbene, but scientists have also discovered the presence of Pterostilbene in other plants, but because it was first discovered in Pterostilbene, it is named Pterostilbene. It is a polyphenol with a structure similar to resveratrol. However, due to slight structural differences, pterostilbene is more lipid soluble. This difference increases the bioavailability of pterostilbene. Pterostilbene has anti-cancer, anti-inflammatory, antioxidant and analgesic properties. A large number of studies have shown that pterostilbene has a good effect in the treatment and protection of skin diseases, especially in the fields of antioxidant and other fields. Pterostilbene is a white or off-white powder crystal, which has rich medicinal value and is an antifungal active ingredient in blood products.
The function of the pterostilbene
1. Anti-oxidation effect
Like vitamins C and E, pterostilbene has been shown to help reduce free radical damage. In published studies, pterostilbene has been found to exhibit direct antioxidant effects while also modulating antioxidant enzymes and defense systems throughout the body. It has been hypothesized that many of pterostilbene's potential health benefits are related to its antioxidant effects.
2. Alleviate inflammatory response activity
Increased inflammatory response activity in the body is associated with many chronic diseases. Nitric oxide is a signaling molecule that plays an inflammatory role in the immune response. Cyclooxygenase (COX) is an independent inflammatory response signaling molecule that can be controlled by aspirin and ibuprofen. Both of these inflammatory response signaling molecules appear to be controlled by pterostilbene. Excessive levels of these two enzymes have been linked to several chronic diseases.
3. Pain relief effect
Evidence for the pain-relieving properties of pterostilbene is still in its early stages and mostly lacks human medical trials. While the aforementioned anti-inflammatory effects suggest that pterostilbene has potential as a means of repairing pain and inflammatory responses, human data are extremely limited. However, studies in animals generally confirm pain-reducing effects. A recent study found a reduction in swelling and inflammation in a rat model of joint problems. In addition, pterostilbene optimizes the composition of intestinal flora, reduces pathological bacteria throughout the digestive tract, and may also help reduce inflammatory responses.
4. Balance blood sugar
Animal data for pterostilbene strongly suggest a benefit for diabetic disorders, but data from human medical trials are needed. Some early studies administered pterostilbene to rats with glycometabolic disease. Researchers found that pterostilbene was as effective in controlling blood sugar as metformin, a standard prescription for glucose metabolism disorders. Other animal studies of glycometabolic diseases have found some protective effects of pterostilbene. Kidney damage (common in glycometabolic diseases) can be controlled by pterostilbene. Patients with glycometabolic diseases often have poor wound healing capabilities. Topical pterostilbene optimizes burn healing in rats with glycometabolic disease. Another well-known complication of glycometabolism is hearing loss. In rats with glycometabolism, pterostilbene was shown to help protect against hearing loss by mitigating free radical damage.
5. Anti-obesity effect
Pterostilbene has been shown to increase calorie expenditure in brown adipose tissue. Brown adipose tissue is a type of fat found in the body that uses heat to generate heat. White adipose tissue is adipose tissue associated with weight gain and obesity. Brown adipose tissue is metabolically active and burns excess calories, which is beneficial for weight loss. Additionally, pterostilbene was found to help change the behavior of white adipose tissue to be more like brown adipose tissue and burn more calories. At the same time, pterostilbene has also been shown to prevent the replication of fat cells and the absorption of fat in white adipose tissue. The effect of pterostilbene on rebalancing the gut flora also appears to play a role in reversing obesity.
6. Brain protection
A preliminary trial in older rats supplemented pterostilbene and tracked the animals' cognitive function. In this study, pterostilbene was able to reverse age-related cognitive decline. These benefits include optimizing memory. Acetylcholine is a key neurotransmitter, and it is reduced in dementia. Research shows that pterostilbene helps combat this decline by reducing its metabolism and breakdown. Other animal studies in different models confirmed these findings, showing optimization of memory performance and increases in acetylcholine levels. In a mouse model of accelerated aging, pterostilbene helped prevent memory loss and optimized inflammation and other signs of dementia pathology.
7. Heart Health Benefits
Studies have found that, also in animal models, pterostilbene protects the heart from damage or optimizes heart function, even during acute heart failure or after a heart attack. Preliminary human trials also suggest that pterostilbene has potential blood pressure control effects. With more medical trials in humans, pterostilbene may show significant heart benefits like some other natural compounds, including CoQ10, carnitine, and garlic extract.
8. Excellent whitening and anti-aging effect
Pterostilbene has a strong ability to inhibit melanin and has an efficient freckle removal effect. Pterostilbene has excellent antioxidant effects and can also protect against ultraviolet rays. Pterostilbene can reduce the content of cross-linked proteins, inhibit the glycation reaction, reduce the production of AGEs, and achieve the effect of dispelling jaundice and anti-aging.
Synthetic method of the pterostillbene
Using 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde as raw materials, the target compound was obtained through Witting-Hornor reaction, reduction, diazotization, and hydrolysis. The natural polypeptide was synthesized with a total yield of 53.9%. Functional antioxidant pterostilbene, and the structure of the target substance was characterized using IR, 1H NMR and EI-MS. The synthesis process is simple, easy to operate, low in production cost, and has good industrial application prospects.
Animal studies and pre-medical models strongly suggest the great potential of pterostilbene. Recent research has found antioxidant, inflammation-reducing, pain-relieving, blood-sugar-balancing, and heart- and brain-protecting benefits. Unlike many other promising natural compounds, pterostilbene is well absorbed and evenly distributed in the body. As human medical research advances, pterostilbene may be a potential remedy for some challenging medical conditions.
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