Do you know what berberine hydrochloride is?

Do you know what berberine hydrochloride is?

Berberine hydrochloride powder, also known as berberine, is an alkaloid extracted from plants such as Coptis chinensis and Phellodendron chinense. It is a yellow crystalline powder, easily soluble in boiling water, slightly soluble in cold water, and almost insoluble in cold ethanol, chloroform and ether. It belongs to the isoquinoline alkaloids chemically and has certain medicinal value. It is mainly used as an antibacterial drug. It has inhibitory effects on Escherichia coli, Staphylococcus aureus, Streptococcus, Salmonella typhi and amoeba. It is mainly used clinically for intestinal infections and bacillary dysentery. It has also been found that this product has anti-arrhythmic effects.

What are the advantages of Berberine Hydrochloride?

Antibacterial: It has inhibitory effect on a variety of bacteria, fungi and protozoa. It is commonly used to treat intestinal infections such as bacillary dysentery and enteritis caused by E. coli. In addition, it also has certain antibacterial effects against amoeba, giardia and trichomonas.

Blood Sugar Regulation: One of the most well-known benefits is its ability to help regulate blood sugar levels. It enhances insulin sensitivity by activating an enzyme called AMPK, which helps lower blood sugar levels, making it a valuable supplement for managing diabetes or prediabetes.

Cholesterol and Cardiovascular Health: Studies show the ability to lower LDL cholesterol and triglycerides while increasing HDL cholesterol. This balance can significantly reduce the risk of cardiovascular disease.​

Cardiovascular protection: It has a certain protective effect on the cardiovascular system. It can improve arrhythmias, especially ventricular arrhythmias, and help lower blood pressure, thus having certain benefits for patients with hypertension.

Anti-inflammatory and antioxidant properties: This compound’s anti-inflammatory effects may help relieve chronic diseases associated with inflammation, while its antioxidant properties may protect cells from damage from oxidative stress.​

Digestive Health: Supports gut health, promotes a healthy balance of gut flora, and helps treat gastrointestinal issues such as diarrhea and irritable bowel syndrome (IBS).

What is the mechanism of antibacterial action?

Reduce the number of pili on the surface of bacteria: It can reduce the number of pili on the surface of pathogenic bacteria, which helps to inhibit the attachment of Gram-positive and Gram-negative bacteria, thereby preventing them from growing on specific surfaces.

Inhibit the activity of topoisomerase: It can affect the DNA synthesis of bacteria, and affect the cell division and growth of bacteria by inhibiting the activity of topoisomerase I and topoisomerase II.

Inhibit the function of FtsZ cell division protein: By inhibiting the function of FtsZ cell division protein, it directly hinders the growth of bacteria such as Escherichia coli.

Destroy bacterial cell membrane: It can combine with substances such as phospholipids on the bacterial cell membrane, destroy the structure and function of the bacterial cell membrane, and leak the contents of bacteria, thereby playing a bactericidal role.

Broad-spectrum antibacterial effect: It has an inhibitory effect on a variety of Gram-positive and Gram-negative bacteria, especially Shigella dysenteriae, Escherichia coli, Staphylococcus aureus, Streptococcus, Pneumococcus, Salmonella typhi, and amoeba.

How is it used in the health field?

Dietary supplements: It is a common dietary supplement ingredient designed to support metabolic health. It can be purchased in the form of capsules, tablets, or berberine hydrochloride powder, which is easy to incorporate into daily health plans.

Blood sugar management: For people with type 2 diabetes or insulin resistance, berberine hydrochloride supplements are often used as an adjunct therapy to conventional medications.

Weight loss programs: Due to its effects on metabolism and fat regulation, health professionals may recommend berberine hydrochloride as part of a comprehensive weight loss program.

Cholesterol control: It is often used to help manage cholesterol levels, often as a natural alternative to statins for those seeking a holistic approach to heart health.

Oral ulcers: With antibacterial, anti-inflammatory and healing properties, studies have shown that applying a gel containing berberine can reduce pain, redness, oozing, and ulcer size in people with oral ulcers.

Precautions

• It is contraindicated for people who are allergic to it and patients with hemolytic anemia. It should be contraindicated for children with hereditary 6-phosphogluconate dehydrogenase deficiency because it can cause hemolytic anemia and jaundice. It should be used with caution in the first three months of pregnancy.
• It cannot be used in combination with Chinese medicine containing tannins. It is an alkaloid, and tannin is an alkaloid precipitant. The combination of the two will produce insoluble tannate precipitation, reducing the efficacy.
• It is not effective for all diarrhea, only for infectious diarrhea.
• It cannot be used to prevent diarrhea, and long-term use may cause drug resistance.
• For long-term use, it needs to be used reasonably under the guidance of a doctor.

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