Discover The Health Benefits Of Troxerutin: A Powerful Natural Antioxidant
Ⅰ、Introduction to troxerutin
Troxerutin is an organic compound with the chemical formula C33H42O19. It is mainly used as a capillary protective drug. Troxerutin is yellow, yellow-green or light brown powder; odorless, slightly salty in taste; hygroscopic. This product is easily soluble in water, slightly soluble in methanol, very slightly soluble in ethanol, and insoluble in chloroform. Troxerutin is a water-soluble derivative of rutin, which has quercetin similar to rutin, while quercetin and other glycosides (such as rutin, hyperoside etc.) all have significant central and peripheral analgesic effects, and their analgesic mechanism is related to reducing the calcium ion content of nervous tissue.
Ⅱ、The efficacy of troxerutin
Troxerutin can inhibit platelet aggregation and prevent thrombosis. At the same time, it can resist vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability. It has a significant protective effect on acute ischemic brain injury.
Ⅲ、Application of troxerutin
Troxerutin can inhibit platelet aggregation and prevent thrombosis. At the same time, it can resist vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability. It has a significant protective effect on acute ischemic brain injury.
Troxerutin can increase the resistance of capillaries, reduce the permeability of capillaries, and relieve the problem of skin redness. Troxerutin has anti-radiation damage and anti-allergic effects, and can be added to sunscreen cosmetics to repair skin sunburn caused by ultraviolet radiation. At the same time, it can also obviously eliminate the active oxygen free radicals produced by cells, maintain the normal metabolism of cells, and its effect is far greater than that of vitamin E.
Troxerutin is mainly used in sunscreen and anti-allergic cosmetics, such as lotion, lotion, essence, mask, sunscreen, facial cleanser, etc.
Ⅳ、The role of Troxerutin in cosmetics:
1. Antioxidant
Troxerutin has strong antioxidant properties that can help reduce skin damage from UV rays and pollutants. These harmful substances can lead to skin aging, discoloration, loss of elasticity and luster. Troxerutin can protect skin cells from these harmful substances by scavenging free radicals, resulting in healthier and younger looking skin.
2、Whitening agent
Troxerutin is also widely used as a whitening agent. It can inhibit the activity of tyrosinase, thus reducing the production of melanin. Melanin is one of the main causes of skin darkening. By using cosmetic products containing Triclopyr, the production of melanin can be reduced, resulting in brighter and more even skin.
3、Promote skin cell regeneration and repair
Troxerutin can promote the regeneration and repair of skin cells. It can stimulate the production of collagen, which is an important part of skin elasticity and luster. By using cosmetic products containing tretinoin, it can help restore the health of the skin, thus making it look younger and more vibrant.
4, Relieve skin inflammation and allergies
Troxerutin also has sedative and anti-inflammatory effects. It can relieve problems such as skin inflammation and allergies. If your skin is prone to redness, itching or problems such as eczema, using cosmetics that contain tretinoin can help alleviate these discomforts.
Ⅴ、How to use troxerutin rationally
Medications must be used rationally and abuse avoided. Prescription medicines should be prescribed by a doctor, and over-the-counter medicines should read the package insert carefully.
Troxerutin is a prescription drug and must be prescribed by a doctor based on your condition. Self-medication may increase your risk of irrational drug use: wasting drug resources, delaying your condition, developing drug resistance, and causing serious adverse drug reactions.
Troxerutin needs to be applied in sufficient amount and for a sufficient course of treatment. Your symptoms may be relieved before the disease is completely controlled, but you cannot reduce the dosage or stop the medication easily to avoid the development of drug resistance, recurrence or aggravation of the disease again.
Ⅵ、Preparation method of Troxerutin
A preparation method of high purity triclopyr, characterized in that it includes the following steps.
1. Synthesis of triclopyr, rutin and catalyst are mixed uniformly and put into a high-pressure reactor, ethylene oxide is passed into methanol and then poured into the high-pressure reactor, the high-pressure reactor is closed, the reaction pressure is controlled to be no higher than 0.5MPa, the reaction temperature is 50-80°C, the reaction is stopped when the content of trihydroxyethyl rutin is the highest by HPLC sampling and monitoring, and the reaction solution is adjusted with hydrochloric acid at a pH of 5-6 and then Cooling crystallization and filtration or spin evaporation of methanol to obtain triclopyr, said catalyst is sodium methanol or sodium ethanol, the mass ratio of rutin to catalyst is 10-15:1, the mass ratio of rutin to ethylene oxide is 3-4:1, and the volumetric dosage of methanol is 3-5 times of the mass of rutin;
2. The refining of triclopyr, the cooling crystallization extraction or spinning methanol to get triclopyr is moved into the extraction crystallization reactor, so that it is at the lower end of the crystallization frame, close the outlet valve, no higher than the flow rate of 2L/min to the extraction crystallization reactor into the C02 until the pressure reaches 6-10MPa, the temperature is set to 50-80 ° C, stirring at a speed of 350 r / min, l-3h After the release of CO2, with the reduction of CO2 crystallization plate precipitation of high purity Troxerutin.
Ⅶ、Identification of Troxerutin
1. Take about 20mg of this product, add 20ml of water, 1ml of hydrochloric acid and a small amount of zinc powder, heating on a water bath, showing a persistent red color.
2. Take about 20mg of this product, add 20ml of water and a small amount of aluminum trichloride, the solution shows bright yellow.
3. Take this product, add water to make a solution containing 20μg per 1ml, according to the spectrophotometric method (Chinese Pharmacopoeia 2000 version of the second part of Appendix ⅣA), there is a maximum absorption at the wavelengths of 254nm and 347nm, and there is a minimum absorption at the wavelength of 283nm.
Ⅷ、Development prospect of troxerutin industry
Troxerutin for injection is one of the main products in the cardiovascular field. Troxerutin preparations are common anticoagulant and thrombolytic drugs in clinical practice and have been included in the National Medical Insurance Catalogue. Its main function is to inhibit the aggregation of red blood cells and platelets, prevent thrombus formation, increase blood oxygen content, improve microcirculation, resist vascular damage caused by serotonin and bradykinin, and increase the resistance of capillaries. Its main indications are the treatment of ischemic cerebrovascular disease, thrombophlebitis, central retinitis, varicose veins, arteriosclerosis, coronary heart disease, etc.
There are many companies in the domestic troxerutin preparation market, and the main players include Anhui Hongye, Ruiyang Pharmaceutical, Jilin Jinsheng, etc. The above-mentioned companies account for a relatively large market share of troxerutin for injection in public hospitals. The troxerutin preparations approved in my country are divided into injection form, tablet form, solution form and capsule form, and the injection form occupies the main market share. From 2015 to 2023, the sales of troxerutin preparations in public hospitals in my country will continue to grow.
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