Withanolide powder

What is withanolide powder?

Withanolide powder is a brown powder extracted from Ashwagandha, also known as Indian ginseng, an authentic medicinal material native to India and available everywhere. Ashwagandha is recognized for its significant antioxidant capabilities and immunity-boosting properties. To date, more than 12 alkaloids and 40 steroidal lipid compounds have been isolated from Ashwagandha.

Among them, withanolide has attracted attention due to its wide range of pharmacological activities (antibacterial, anti-inflammatory and immunomodulatory activities, etc.).
Withanolide is a natural steroid compound with 28 carbon atoms and an ergostane skeleton structure. It can be divided into 2 types (Type A and Type B) based on the difference in the C-17 side chain. Most of them belong to Type A structure type. Studies have shown that there is a certain structure-activity relationship between its structure and activity, such as the α, β-unsaturated ketone structure of ring A (left) and the 5β, 6β-epoxy group of ring B (right). Essential group to exert pharmacological activity.

Effect:

1. Anti-inflammatory effect
It has obvious anti-inflammatory effects and can effectively relieve inflammatory reactions. Research shows that by inhibiting the production and release of inflammatory factors, it regulates immune system function and reduces inflammatory damage. Its anti-inflammatory mechanism involves multiple signaling pathways, including NF-KB, MAPK, etc., thereby exerting a comprehensive anti-inflammatory effect.
2. Antibacterial effect
It has broad-spectrum antibacterial activity and has obvious inhibitory effects on a variety of pathogenic microorganisms. Experimental studies have shown that it can bind to bacterial cell membranes and interfere with their normal functions, thereby inhibiting bacterial growth and replication. In addition, it can also interfere with the signal transduction system of bacteria and reduce their virulence and drug resistance, which has good application prospects.
3. Antioxidant effect
It is a powerful natural antioxidant that can neutralize free radicals, scavenge oxidative substances, and protect cells from oxidative damage. Studies have found that it can enhance the activity of antioxidant enzymes in the body and improve resistance to oxidative stress. In addition, it can also repair DNA damage, improve the DNA stability of cells, and has good anti-aging and anti-disease functions.
4. Beauty and beauty effects
It has good beauty and beauty effects and is often used in skin care products. It can regulate the skin's oil secretion, improve the problem of enlarged pores, brighten skin tone, and reduce the formation of dark spots and freckles. In addition, it can also promote the synthesis of collagen, enhance the elasticity and firmness of the skin, and slow down the relaxation and aging of the skin.
5. Lower blood sugar
Has the effect of lowering blood sugar. The compound promotes the release of insulin and increases insulin sensitivity, which helps regulate blood sugar levels and could be a potential diabetes management tool for people with diabetes.
6. Reduce symptoms of anxiety and depression
Preliminary research suggests it may have some relief from symptoms of anxiety and depression. It affects neurotransmitters in the brain, regulating mood and emotional responses.
7. Anti-SARSCoV-2 effect
Potential to inhibit SARSCoV-2 host cell TMPRSS2 receptor and protease. Through extensive computational and experimental analysis of 9 withanolide compounds, it was found that in in vitro experiments, the expression of TMPRSS2 receptor in cells treated with withanolide was down-regulated and the replication of SARS-CoV-2 was inhibited (IC50 = 0.01 μM).

Application areas:

1.Pharmaceutical field
Able to inhibit inflammatory responses and can be used to treat chronic inflammatory diseases such as lupus and arthritis.
Immunomodulation: Thought to enhance immune system function.
Neuroprotection: May have protective effects on the nervous system and help alleviate neurodegenerative diseases.
2. Health Supplements
It is also widely used in health supplements, especially in the following aspects:
Anti-fatigue: It can help restore energy, especially for people who are overworked or mentally fatigued.
Improves sexual function: Thought to improve sexual function and reduce leucorrhea.
Adaptogens: In the European and American dietary supplement markets, they are classified as adaptogens, which means they can help the body balance its response to stress and make people calm or rejuvenated.
3. Food and cosmetics
Antioxidant: It has significant antioxidant capacity, which makes it potentially useful as an anti-aging ingredient in cosmetics.
Functional Foods: Due to their various health benefits, they can also be added to functional foods to enhance the nutritional value of the product.
Formulation
Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Withanolide powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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