Tanshinone powder

What is tanshinone?

Tanshinone powder is a fat-soluble phenanthrenequinone compound with antibacterial effects extracted from the traditional Chinese medicine Salvia miltiorrhiza (Lamiaceae plant Salvia miltiorrhiza root). From it, more than 10 types of tanshinone I, tanshinone IIA, tanshinone IIB, cryptotanshinone, and isocryptotanshinone are extracted. There are 5 tanshinone monomers, among which 5 monomers: cryptotanshinone, dihydrotanshinone II, hydroxytanshinone, tanshinone methyl ester, and tanshinone IIB, have antibacterial effects, as well as anti-inflammatory and cooling effects. Tanshinone IIA sodium sulfonate, the sulfonated product of tanshinone IIA, is soluble in water. Clinical trials have proven that it has significant effects in treating angina pectoris with few side effects. It is a new drug for the treatment of coronary heart disease. Tanshinone has many functions such as antibacterial, anti-inflammatory, promoting blood circulation and promoting wound healing. There are no obvious side effects after long-term use.

Tanshinone compounds are the main representatives of the fat-soluble components of Salvia miltiorrhiza and are widely distributed in the body. Together with salvianolic acid compounds, they have been confirmed to be the most important characteristic and active ingredients of Salvia miltiorrhiza. They have the functions of protecting vascular endothelium, improving microcirculation, and anti-inflammatory. , anti-infection and other effects. This type of compounds includes tanshinone I, tanshinone IIA, tanshinone IIB, dihydrotanshinone, cryptotanshinone, isocryptotanshinone, hydroxytanshinone, methyl salvinate, dihydrotanshinone I, tanshinone III, isotanshinone I, isotanshinone IIA, L-2 Hydrotanshinone I, Salvia quinone A, Salvia quinone B, Salvia quinone C and other ingredients. Among them, tanshinone IIA has the most prominent activity, and its content is about 0.1% to 0.9% of the salvia miltiorrhiza.

What are the benefits?

1. Antibacterial effect

In vitro experiments, tanshinone has a stronger antibacterial effect on Staphylococcus aureus than berberine, and it also has an inhibitory effect on Mycobacterium tuberculosis H37RV strain (the minimum inhibitory concentration can reach less than 1.5 mg/mL) and two types of trichophyton.

2. Anti-inflammatory effect

Tanshinone administered by gavage to rats had significant anti-inflammatory effects. In the first stage of inflammation model, it has a significant inhibitory effect on the increase in capillary permeability caused by histamine; it has an inhibitory effect on acute joint swelling caused by egg white, carrageenan and dextran; it has an inhibitory effect on exudative formaldehyde peritonitis. effect. In the second stage of inflammation model, it has a significant inhibitory effect on the migration of white blood cells in mice caused by gelatin; it has a significant inhibitory effect on subacute formaldehyde joint swelling. For the third-stage inflammation model, the cotton ball granuloma test has no inhibitory effect (ie, no effect in the chronic stage). Tanshinone can reduce the levels of PGF2α and PGE in the blood of rats, which may be related to the anti-inflammatory mechanism of tanshinone.

3. Anticoagulant effect

Tanshinone has anticoagulant effects. The effect is stronger than that of protoethyl aldehyde.

4. Other functions

Tanshinone can improve the survival rate or extend the survival time of mice under hypobaric hypoxia. Tanshinone has anti-androgenic effects, reducing sebum production, and has anti-Propionibacterium acnes effects, reducing inflammation exacerbated by bacterial metabolism. Can be used to treat acne. Tanshinone has an antipyretic effect on rabbits with fever caused by typhoid vaccine. Experiments in mice indicate that tanshinone has mild estrogenic activity that acts through the ovaries.

5. The in vivo process was observed to see how tanshinone enters the liver and is excreted in the bile after duodenal administration. The results show that trace amounts of tanshinone can be measured in the bile after duodenal administration in rats in about 1 hour. The peak discharge is about 3 hours after administration. Tanshinones with different structures are excreted in the liver at different rates. In addition, the experiment also found that after using chloroform to extract tanshinone from bile, denatured protein was precipitated in the aqueous solution of bile, and there was a certain relationship between its content and different administration groups.

Application direction

Tanshinone powder has unique biochemical activities and is widely used in traditional Chinese medicine to treat a variety of diseases and symptoms, especially problems related to qi stagnation and blood stasis. This drug is believed to have the effects of activating blood circulation and removing blood stasis, relaxing muscles and activating collaterals, and is therefore used in traditional Chinese medicine to treat chest and abdominal pain, rheumatic arthralgia, and mass agglomeration. It helps promote blood circulation, reduce inflammation and congestion, and relieve pain. In traditional Chinese medicine theory, this drug is often classified as a drug for qi stagnation and blood stasis. This means it helps relieve problems caused by poor Qi and blood flow, such as pain, lumps, congestion, etc. When treating such diseases, tanshinone I is often used in combination with other herbs such as amomum villosum and sandalwood to enhance the efficacy. As a natural product molecule, tanshinone I has unique biochemical activity and can be used to treat thoracic and hypochondriac pain, rheumatic arthralgia, mass agglomeration, sores, swelling and pain, falls and other trauma. This compound is often used in conjunction with amomum villosum, sandalwood and other medicines to treat chest and abdominal pain caused by qi stagnation and blood stasis. In addition, this substance also has a certain impact on the production of plant growth hormones.

Tanshinone IIA supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality Tanshinone powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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