Shikimic Acid Powder

What is shikimic acid?

Shikimic Acid Powder is a white crystalline powder that is easily soluble in water. It is named after it was first isolated from M. japonica and is an important metabolite of plants and microorganisms. For a long time, shikimic acid has been mainly extracted from the dried and mature fruits of star anise or Japanese shiki (Japanese anise). In recent years, there are also research reports on the extraction of shikimic acid from the fruits of North American liquidambar and pine needles.

Plant Source

Shikimic acid is found in the dried and ripe fruits of star anise, a plant in the Magnoliaceae family. Anise is an evergreen tree that grows in a humid, warm semi-shady environment and can reach a height of 30 meters. Mainly distributed in mountainous areas with loose soil in Fujian, Guangdong, Guangxi, Yunnan, Guizhou and other provinces. The bark is gray to reddish brown. The leaves are oval, entire-margined, lanceolate in growth, leathery, short-stalked, 6-12 cm long, 2-5 cm wide, with transparent oil spots visible on the upper surface. Blooms in spring and autumn. Flowers are solitary in leaf axils. There are 3 yellow-green sepals; 6-9 perianths, pink to deep red. Fruits from autumn to spring of next year. The aggregate fruit is star-shaped and octagonal, 1-2 cm long, 3-5 cm wide, and <1 cm high. It turns from green to yellow when mature. The top of the follicles is blunt or blunt-pointed, and each contains a 6 mm long seed. The fruits are picked in autumn and winter and turn reddish-brown or yellow-brown after drying. The smell is aromatic and sweet. Mangcao, also known as wild anise, is a shrub that is evergreen all year round. The seeds are light brown and shiny. The flowering period is in May and the fruiting period is from September to October. It is mainly distributed in the jungles of barren hills and slopes below 1200 meters. It bears fruit in autumn. , the fruit contains a large amount of shikimic acid. The fruit is very similar to star anise, but it is poisonous, so confusion should be avoided.

What are the benefits?

Shikimic Acid Powder is a monomeric compound that has anti-inflammatory and analgesic effects, and can also be used as an antiviral drug intermediate. Shikimic acid affects the metabolism of arachidonic acid, inhibits platelet aggregation, and inhibits the formation of arterial and venous thrombosis and cerebral thrombosis. Preliminary research by the Pharmacology Research Laboratory of Beijing University of Chinese Medicine found for the first time that shikimic acid has significant anti-thrombotic effects and can inhibit the formation of arterial and venous thrombosis and cerebral thrombosis. In order to elucidate its anti-thrombotic mechanism, researchers studied the effect of shikimic acid on platelet aggregation and coagulation, and analyzed the relationship between its mechanism of action and arachidonic acid metabolism. The results suggest that shikimic acid may exert anti-thrombotic effects by affecting arachidonic acid metabolism, inhibiting platelet aggregation, and inhibiting the coagulation system.

(1) Antibacterial effect:

Studies have reported that shikimic acid can be used as the original product to synthesize ceylon snowflakes (polyoxycyclohexane substances). This derivative can significantly inhibit the transmission of nucleotides in Eichli ascites cancer cells and has an effect on cancer cells cultured in vitro. Cells are toxic.

(2) Anti-inflammatory and analgesic effects:

Through experimental research, Xing Jianfeng and others found that isopropylshikimic acid (ISA) can not only inhibit exudation and edema in the early stage of inflammation, but also inhibit the proliferation of tissue and the formation of granulation tissue in the late stage of inflammation, and has obvious anti-inflammatory effects.

(3) Anti-thrombotic effect:

Preliminary research by the Pharmacology Research Laboratory of Beijing University of Chinese Medicine found for the first time that shikimic acid has significant anti-thrombotic effects and can inhibit the formation of arterial and venous thrombosis and cerebral thrombosis. Shikimic acid can inhibit platelet aggregation and coagulation system by affecting arachidonic acid metabolism, thereby exerting anti-thrombotic effects.

(4) Anti-avian influenza effect: Oseltamivir (Tamiflu), a neuraminidase inhibitor produced by the Swiss company Roche, is a new anti-influenza virus drug. Experimental studies have shown that it has an inhibitory effect on avian influenza viruses H5N1 and H9N2. , and shikimic acid is an important raw material for the synthesis of "Tamiflu" and can be synthesized by modifying the structure of shikimic acid. These medicinal values of shikimic acid make it have good economic value.

Application direction

Shikimic Acid Powder is a key precursor in the synthesis of many alkaloids, arylamine acids, indole derivatives and chiral drugs. Recently, shikimic acid has been used as the starting material for oseltamivir (the active ingredient of Tamiflu), a neuraminidase inhibitor that can be used to treat and prevent influenza A and influenza B.

Shikimic Acid supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk Shikimic Acid Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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