Salvianolic Acid B Powder

What is salvianolic acid?

Salvianolic Acid B Powder is an organic compound with a molecular formula of C36H30O16 and a relative molecular mass of 718.62. It tastes slightly bitter and astringent and has hygroscopic properties. Soluble in water.

Salvianolic acid B is the condensation of three molecules of salvianoside and one molecule of caffeic acid. It is one of the most studied salvianolic acids and has important pharmacological effects on the heart, brain, liver, kidney and other organs. This product has the effect of promoting blood circulation and removing blood stasis, dredging the meridians and activating meridians. It is mainly used to treat ischemic stroke caused by blood stasis blocking the meridians. Symptoms include numbness of the body and limbs, weakness, spasm and pain, or inability to move, crooked mouth and eyes, etc.

Salvianolic acid B (Sal B) is a water-soluble component extracted from Salvia miltiorrhiza. It is a phenolic acid compound formed by the condensation of 3 molecules of salvianoside and 1 molecule of caffeic acid. The chemical structure of salvianolic acid B contains 9 phenolic hydroxyl groups, which can provide active hydrogen to prevent lipid peroxidation. Studies have shown that salvianolic acid B has strong antioxidant and free radical scavenging effects in different free radical generating systems. Salvianolic acid B has a variety of pharmacological activities and can exert its effects on blood vessels through multiple pathways and multiple targets. It has a wide range of applications in the treatment of cardiovascular diseases.

What are the benefits?

1. Antioxidant

Research shows that salvianolic acid B can scavenge oxygen free radicals and inhibit lipid peroxidation. It is one of the natural products known to have strong antioxidant effects. Studies have found that salvianolic acid B can improve histopathological damage in rats, prevent the leakage of serum creatine kinase (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH), and significantly improve Rat catalase (CAT), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) activities. In in vitro experiments, salvianolic acid B can reduce the activity of LDH in the culture supernatant and the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in myocardial cells, and has a certain protective effect on myocardial cell apoptosis. It also has Helps improve its antioxidant properties.

2. Anti-apoptosis

Studies have found that salvianolic acid B can induce apoptosis in the cardiovascular intima and prevent the thickening of the cardiovascular endothelium. After treatment of acute myocardial infarction (AMI) rats with salvianolic acid B, it was found that salvianolic acid B can inhibit the polyadenosine diphosphate ribose polymerase-1 (PARP-1) pathway and improve the mitochondrial and nuclear stability of rat myocardial tissue. integrity and inhibit cardiomyocyte apoptosis. By establishing a diabetes (DM) model, it was found that salvianolic acid B may resist the oxidative stress damage of cardiomyocytes induced by high-glucose culture and cardiomyocyte apoptosis by activating the expression of nicotinamide adenine dinucleotide-dependent enzyme (SIRT1). Death.

3. Protective effect against myocardial infarction

The coronary artery ligation method was used to construct a rat myocardial infarction (MI) model, and the protective effect of salvianolic acid B on MI was investigated. The results showed that compared with the control group, salvianolic acid B could exert a significant cardioprotective effect on MI. Mechanistic studies have shown that salvianolic acid B mainly inhibits the upregulation of leptin and endothelin-reactive oxygen species (ET-ROS) and restores the sarcoplasmic reticulum calcium ATPase 2a (sarco/endoplasmic) in myocardium. reticulum ATPase 2a, SERCA2a) and phospholamban, thereby exerting a protective effect on the heart.

4. Inhibiting myocardial cell hypertrophy

In studying the effect of salvianolic acid B on cardiomyocyte hypertrophy induced by angiotensin Ⅱ (Ang II) in neonatal rats, the results showed that salvianolic acid B could inhibit the hypertrophy of cardiomyocytes induced by Ang Ⅱ, and atrial natriuretic natriuretic acid was also found. The expression of peptide and brain natriuretic hormone mRNA decreased and the cell surface area decreased. Mechanistic studies have found that salvianolic acid B can inhibit the activity of poly(ADP-ribose) polymerase-1, PARP-1, and overexpression of PARP-1 can attenuate the activity of salvianolic acid B. Anti-cardiomyocyte hypertrophy effect, these studies show that salvianolic acid B has a good inhibitory effect on cardiomyocyte hypertrophy.

5. Protective effect against ischemia/reperfusion (MI/R) injury

In the rat myocardial ischemia-reperfusion injury model, salvianolic acid B can reduce the serum CPK level after injury and reduce the size of myocardial infarction. Salvianolic acid B can also significantly inhibit the activation of the renin-angiotensin-aldosterone system, regulate the levels of PGI 2 and TXA2, and reduce the release of inflammatory cytokines. These results confirm the protective effect of salvianolic acid B on ischemia-reperfusion cardiomyocytes from the perspective of inhibiting inflammatory response. Salvianolic acid B also showed similar effects in the hypoxia-reoxygenation model of isolated hearts and cultured cardiomyocytes. Studies have shown that the combined use of salvianolic acid B and 5-azacytidine can induce the directional differentiation of rat bone marrow mesenchymal stem cells into cardiomyocyte-like cells. The mechanism of action may be that salvianolic acid B promotes the secretion of certain cells by bone marrow mesenchymal cells. factors, which in turn affect the expression of genes NKX2.5 and GATA-4 that are beneficial to the formation of cardiomyocyte-like cells and promote the expression of cardiomyocyte structural proteins, thereby inducing the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells.

6. Anti-atherosclerotic effect

Salvianolic Acid B Powder can inhibit the upregulation of MMP-2 and MMP-9 expression and the expression of COX in human aortic smooth muscle cells (HASMCs) induced by various factors. In vitro experiments have also confirmed that salvianolic acid B can reduce the thickening of the aortic intima. The effect of salvianolic acid B on the expression of cell adhesion molecules was studied using human aortic endothelial cells (HAECs). The results show that both Salvia miltiorrhiza aqueous extract and salvianolic acid B can significantly reduce the expression of VCAM-1 and ICAM-1, reduce the binding of human monocyte cell line U937 to TNF-α-treated HAECs, and inhibit TNF-α-induced Activation of NF-κB in HAECs. The anti-inflammatory properties of salvianolic acid B provide new evidence for elucidating the anti-atherosclerotic effect of salvianolic acid B. Another study found that salvianolic acid B can scavenge free radicals in the circulation, reduce the consumption of vitamin E, indirectly prevent LDL from being oxidatively modified, and play a role in delaying the development of atherosclerosis.

7. Vasodilation

The vasodilatory effects of Salvia miltiorrhiza aqueous extract and salvianolic acid B are mainly related to the inhibition of L-type voltage-dependent Ca2+ channels. The strong vasodilatory effect of salvianolic acid B and its high content in Salvia miltiorrhiza aqueous extract suggest that salvianolic acid B is an important component of the traditional Chinese medicine Salvia miltiorrhiza that exerts vasodilation effect. Under physiological and pathological conditions, Ca2+-activated K+ channel (BKCa) and ATP-dependent K+ channel (IKATP) both play an important role in regulating coronary artery tension. Studies have shown that only salvianolic acid B in the crude extract of Salvia miltiorrhiza can activate guanylyl cyclase and induce the opening of BKCa channels in smooth muscle cells.

Salvianolic Acid B supplier

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