Saikosaponin

What is saikosaponin?

Saikosaponin is a triterpenoid saponin extracted from bupleurum, and is the main bioactive compound of bupleurum. It is mainly found in the roots of bupleurum and bupleurum of the Umbelliferae family. It has multiple pharmacological effects, including anti-inflammatory and antibacterial. It can exert its effects in many ways, such as regulating the immune system, inhibiting inflammatory responses, and promoting cell apoptosis. It is widely used in health care products, cosmetics, medicine and other fields.

Features

1. It has multiple pharmacological effects.
2. It is usually extracted from the dried root of Bupleurum chinense and needs to be stored away from light and kept in dry conditions to avoid moisture absorption.
3. It is generally considered safe, but care should be taken not to use it excessively when using it, and avoid using it simultaneously with certain metal ion-related drugs to avoid affecting absorption.

Effects and functions of saikosaponins

• It is helpful for regulating gastrointestinal function.
• It has an antipyretic effect on artificially fevered rabbits and is suitable for treating symptoms such as exogenous high fever.
• It can protect the liver from damage and help the secretion of bile.
• It can inhibit inflammatory reactions and has an inhibitory effect on ear inflammation in mice, and can be used to treat various inflammations.
• It can improve the function of the immune system, including enhancing phagocytic function, natural killer cell function, and increasing virus-specific antibody titers.
• It can protect liver cells from damage, promote lipid metabolism in the liver, and repair liver damage caused by carbon tetrachloride.
• It can inhibit the decomposition and generation of fat, reduce the fat content in the blood, and help prevent and treat hyperlipidemia.
• It can exert an antidepressant effect by regulating inflammatory factors, downregulating the function of the HPA axis, improving neurotransmitter levels and neuronal cell apoptosis.

Antidepressant mechanism of saikosaponin (SS): improving cortical sphingolipid metabolism and triggering neurovascular coupling via apolipoprotein E

1. Chronic unpredictable mild stress (CUMS) exhibits more severe depressive behaviors in APOE-/- mice

CUMS significantly reduced APOE protein expression.

APOE-/- mice exhibit more severe depressive behaviors in CUMS.

2. APOE deficiency aggravates CUMS-induced lipid metabolism abnormalities

3. SS improves CUMS-induced depressive-like behavior and upregulates APOE expression

SS can improve depressive-like behaviors induced by CUMS exposure.

The SS group can significantly upregulate the expression of APOE, but cannot reverse the CUMS-induced decrease in cerebral blood flow in APOE-/- mice.

4. SS treatment improves sphingolipid metabolism disorder caused by CUMS

SS significantly modulates central lipid metabolism disorders in depressed mice but has no effect on KO depressed mice lacking APOE.

The expression of ASMase increased in the CUMS group, and the expression of ASMase decreased significantly after SS administration.

5.SS increases CUMS-induced decrease in cerebral blood flow by regulating NVC

6. The molecular mechanism of SS improving cortical sphingolipid metabolism and triggering neurovascular coupling through APOE to treat depression.

In conclusion

The antidepressant effect of SS is inseparable from its lipid-lowering effect. Its mechanism includes regulating cortical sphingolipid metabolism through APOE and alleviating the reduction in cerebral blood flow in depressed mice through the NVC mechanism, thereby improving depressive symptoms. These findings provide a basis for the development and application of SS as a clinical antidepressant. Furthermore, our study also increases the possibility of targeting lipid metabolism as a treatment for depression and enriches therapeutic strategies for the development and research of lipid-lowering antidepressants.

Application areas

Medicine

It is used to develop new drugs, especially in anti-inflammatory, antiviral and immunomodulatory aspects. It can be used to treat inflammatory diseases such as hepatitis, colds, bronchitis, etc.

Health products

Due to its antioxidant and immunomodulatory functions, it is also added to health products to improve human immunity and resistance.

Cosmetics

Studies have shown that it has whitening and antioxidant effects, so it is also used in cosmetics to improve skin quality.

Formulation Of Saikosaponin

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Saikosaponin and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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