Phlorizin Powder

What is Phlorizin powder?

Phlorizin powder, also known as phloridzin, is a glycoside compound formed by the combination of phloretin and a glycoside molecule, belonging to the flavonoid subclass of dihydrochalcones. 

It is a phenolic substance extracted from apples, apple peels, leaves, and other parts. One of its degradation products, phloretin, demonstrates effective inhibition of microbial activity. Its accumulation is a distinctive phenomenon in plants of the Malus genus, primarily first extracted from the root bark of apples (Malus domestica). Its content in the peel (ranging from 12 to 418 mg/kg) is significantly higher than that found in different varieties of pulp (4 to 20 mg/kg).

Yuantai Organic Testing:

Fully certified to meet quality inspection requirements of various countries. Employing a High-Performance Liquid Chromatography (HPLC) method in conjunction with an Evaporative Light Scattering Detector (ELSD) or a Diode Array Detector (DAD), we can efficiently and accurately detect changes in phlorizin content within samples.

Key components of the HPLC assay include: 

• Ensuring a sample quantity greater than 0.2g or 0.2mL.

• Cycle: 2 to 3 weeks.

• Following the completion of the project, we will provide a detailed technical report, encompassing:

1. Experimental procedures.

2. Pertinent mass spectrometry parameters.

3. Mass spectrometry images.

4. Raw data.

5. Phlorizin content information.

Research Highlights:

1. PHZ alleviates obesity induced by a high-fat diet (HFD).

2. PHZ mitigates microbiota and metabolic disturbances induced by a high-fat diet (HFD).

3. PHZ mitigates intestinal barrier damage caused by a high-fat diet (HFD).

Correlation between key gut microbial taxa and metabolites (short-chain fatty acids, SCFA, and lipopolysaccharides, LPS).

4. Transplantation of fecal samples from phlorizin (PHZ)-treated mice alleviates obesity and intestinal barrier damage induced by a high-fat diet (HFD).

5. Schematic representation depicting potential mechanisms of phlorizin (PHZ) anti-metabolic disorder (MD) effects.

The function of Phlorizin powder:

1. Impact on Blood Glucose and Lipids: High doses of phlorizin can lead to glucosuria. It reduces glucose absorption in the small intestine and increases renal glucose excretion, effectively lowering blood glucose levels. it promotes glucose secretion, lowering fasting and postprandial blood glucose levels without causing hypoglycemic side effects. Treating diabetic rats with phlorizin restores insulin sensitivity to normal levels. It also exhibits lipid-lowering effects.

2. Cognitive Enhancement: Research suggests that phlorizin enhances memory. It enhances learning and memory abilities in rodents and counteracts insulin-induced memory impairment. Many memory-enhancing drugs function by modulating circulating glucose levels, but it inhibits glucose entry into the brain. Its mechanism for enhancing brain memory seems to operate independently of blood glucose levels or brain glucose absorption capacity.

3. Antioxidant Properties: it is a glycoside derivative of dihydrochalcone phloretin, with notable antioxidant characteristics. Its overall antioxidant capacity surpasses that of vitamin C and vitamin E, with a distinctive antioxidant mechanism. Moreover, it can be hydrolyzed in vivo to form phloretin, displaying superior antioxidant capabilities.

Applications:

Phlorizin belongs to the dihydrochalcone subclass of plant flavonoids .it exhibits various biological activities, such as blood pressure and blood glucose regulation, heart protection, and scavenging of free radicals. Notably, it possesses low toxicity and finds broad applications in multiple fields:

1. Medical: Phlorizin powder inhibits glucose reabsorption in the renal proximal tubule, leading to increased urinary glucose excretion and reduced blood glucose levels, without affecting serum insulin levels.

2. Cosmetics: Phlorizin can be used for skin whitening and acne treatment. It hinders glucose entry into epidermal cells, slowing sebum secretion and aiding in preventing acne. By inhibiting tyrosinase, a key enzyme in melanin biosynthesis, phlorizin contributes to skin whitening.

3. Food: Phlorizin also demonstrates antioxidant properties.

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