Paeoniflorin Powder

What is paeoniflorin?

Paeoniflorin and albiflorin (also known as paeoniflorin, albiflorin) are monoterpene glycosides commonly found in Paeoniaceae plants and are the main components in traditional Chinese medicines white peony root, red peony root and peony bark. Active ingredients and quality control standards, with a variety of pharmacological effects and uses. Total glycosides are a drug for the treatment of rheumatoid arthritis in China. Paeoniflorin and paeoniflorin can be used as active ingredients in related medicines and functions. Food field.

Paeoniflorin Powder is the main active ingredient of Paeoniae Radix Alba, Paeoniae Radix Rubra and Paeonia suffruticosa Andr. It is a water-soluble monoterpene glycoside that was first extracted from peony in 1963. Paeoniflorin is chemically unstable and needs to be stored in a low temperature, frozen environment, and avoid an alkaline environment. Paeoniflorin has various effects such as sedation, anti-inflammatory, analgesia, and improvement of cognitive ability. It is widely used in the clinical treatment and basic research of neurological diseases and neurodegenerative diseases such as Alzheimer's disease, stroke, depression, epilepsy, etc. Research on the pharmacological effects of paeoniflorin on antidepressant, anti-inflammatory, analgesic, hepatoprotective, neuroprotective, immunomodulatory, prevention and treatment of diabetic complications and other pharmacological effects has made great progress. The research progress on the pharmacological effects of paeoniflorin in the past three years was sorted out and summarized to provide reference for the further development and clinical application of paeoniflorin.

What are the benefits?

1. Antioxidant effect: It can scavenge free radicals, reduce oxidative damage, and protect the skin from environmental factors such as ultraviolet rays and pollution.

2. Anti-inflammatory effect: It can inhibit inflammatory reactions and reduce symptoms of skin inflammation such as redness, swelling, and itching.

3. Promote collagen synthesis: It can promote collagen synthesis and enhance skin elasticity and firmness.

4. Inhibit melanin production: It can inhibit melanin production and reduce the occurrence of pigmented skin diseases such as spots and freckles.

5. Moisturizing effect: It can increase the moisture content of the skin, improve the skin's water retention capacity, and make the skin softer and smoother.

6. Anti-inflammatory effect

Early researchers found that paeoniflorin significantly inhibited the expression of chemokine mRNA in human dermal microvascular endothelial cells (HMEC-1) induced by TNF-α and reduced the secretion of chemokines in the culture supernatant; they also found that paeoniflorin inhibited nuclear transcription. Factor-κB (NF-κB) is transported to the nucleus, indicating that paeoniflorin has the anti-inflammatory ability to resist TNF-α-induced chemokine production and leukocyte migration, and its mechanism is related to inhibiting the NF-κB and ERK pathways. It is shown that paeoniflorin has anti-inflammatory effects in vitro and can be used as a candidate drug for the treatment of inflammatory skin diseases.

7.Analgesic effect

Paeoniflorin has an analgesic effect, which is not only effective when used in combination with benzoylaconitine, but also has important value in the independent treatment of various types of pain. Studies have found that the analgesic effect of paeoniflorin may be related to the increase in β-endorphin (β-EP) levels in serum and cerebral cortex and the reduction in the production or release of prostaglandin E2 (PGE2) in the cerebral cortex.

8. Body protection function

1 Protective effect against liver damage

Previous studies have found that paeoniflorin has a certain therapeutic effect on non-alcoholic fatty liver disease, chemical liver injury, radiation liver injury, immune inflammatory liver injury, ischemia-reperfusion liver injury and other diseases, but the mechanism of action has been unclear in recent years. It can be further elucidated, mainly in the aspects of inhibiting inflammatory factors, regulating anti-oxidative stress, regulating immunity and anti-apoptosis. It was found that paeoniflorin can significantly reduce the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the serum of mice, and has a protective effect on liver damage caused by lipopolysaccharide. Studies have found that paeoniflorin has a protective effect on carbon tetrachloride-induced acute liver injury and liver fibrosis. The mechanism may be related to reducing hepatocyte apoptosis, oxidative stress, reducing pro-inflammatory cytokine production, and promoting heme oxygenase- 1 is related to the expression.

2 Neuroprotective effect

Paeoniflorin Powder has obvious protective effects on neurons, neurotoxicity and nerve cell damage. Research in the past 2 years has further clarified this mechanism of action. Studies have found that paeoniflorin inhibits Aβ(1-42)-mediated oxidative stress and hippocampal neuron damage in AD rats by activating the NF-E2-related factor 2/ARE regulatory gene (Nrf2/ARE) pathway. It was found that paeoniflorin can alleviate the loss of neurons caused by tributyltin chloride (TBTC) and reverse the decrease in mitogen-activated protein kinase (MAPK) and JNK levels by inhibiting stress-activated protein kinase (JNK) activity. In addition, it was found that paeoniflorin may prevent or treat neurodegenerative diseases and nerve damage by inhibiting the mitogen-activated protein kinase kinase-4 (MKK4)-JNK signaling pathway.

9. Immunomodulatory effect

Early studies have found that total glycosides of paeony have a therapeutic effect on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In the past two years, literature has reported that paeoniflorin is the main component that exerts immunomodulatory effects. By exploring the effect of paeoniflorin on the phenotype and function of dendritic cells (DCs), we found that paeoniflorin can significantly inhibit the maturation and function of DCs, providing a basis for the treatment of autoimmune diseases with paeoniflorin. Paeoniflorin was found to reduce lipopolysaccharide (LPS)-induced phosphorylation of interleukin receptor 1-related kinase 1 (IRAK 1) and its downstream proteins, and inhibit the expression of TNF-α and IL-6. This indicates that paeoniflorin inhibits LPS-induced cell activation by inhibiting the IRAK 1/NF-κB pathway in macrophages of MRL/LPR mice, and may be a potential treatment for the autoimmune disease systemic lupus erythematosus. These results suggest that paeoniflorin has dual immunomodulatory effects.

10.Other functions

In addition, Paeoniflorin Powder also has pharmacological effects such as improving sleep, antioxidant, regulating blood lipids, and downregulating estrogen levels in the cerebral cortex of premenstrual syndrome.

Paeoniflorin supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk Paeoniflorin Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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