Luteolin Bulk Powder

What is Luteolin Powder?

Luteolin Bulk Powder (5,7,3',4'-Tetrahydroxyflavone), a natural flavonoid compound, is commonly known as luteolin. Its structure is depicted in Figure 1, and it derives its name from being initially isolated from the plant Reseda odorata Linn., belonging to the family Resedaceae. From its structure, it is evident that luteolin is a polyphenolic hydroxyl compound with poor lipophilicity. 

Due to intermolecular forces between hydroxyl groups and a relatively high lattice energy, its solubility in various solvents is low, presenting challenges in both preparation and application.

COA:

Our Advantage:

1. Collaborative Plantation Partnerships: We have cultivated strong collaborations with several natural raw material plantations. This ensures a consistent supply of premium botanical ingredients, sourced directly from nature.

2. In-House Manufacturing Facility: With our own advanced manufacturing facility, we maintain control over every step of the production process.

3. Tailored Formulations: Recognizing the diverse needs of our clients, we offer customization options for extract concentrations and compositions.

4. Established Shipping Channels: Our well-established distribution network ensures smooth and reliable global delivery. We prioritize safe packaging and efficient transportation to guarantee the products reach our clients in optimal condition and on time.

5. Stringent Certification: Our commitment to quality is evident through our comprehensive certifications. Our products meet the stringent quality testing standards of various countries and regulatory bodies, underscoring our dedication to excellence.

Physicochemical Properties

Pure Luteolin Powder is typically found as yellow needle-shaped crystals. It exhibits strong thermal stability, is undoable in cold water, slightly answerable in hot water, readily answerable in organic detergents and alkaline results, and its waterless result is weakly acidic. The waterless result presents a pleasing pale unheroic color and can dissolve in a 10 sodium hydroxide result, turning deep unheroic. Luteolin remains stable under normal conditions. In plants, luteolin is commonly present in the form of its aglycone (a molecule without any sugar attachment) and glycosides (aglycones bound to one or more sugar moieties).

Raw Materials of Luteolin Bulk Powder

Luteolin Bulk Powder is widely distributed in nature. It gained its name due to its initial isolation from the leaves, stems, and branches of the herbaceous plant Reseda odorata L. in the Resedaceae family. It can be isolated from various natural medicinal herbs and vegetable fruits. Presently, it has been discovered in significant quantities in natural medicinal herbs such as honeysuckle, chrysanthemum, mentha, Ajuga decumbus, artichoke, perilla, Scutellaria baicalensis, and Gentiana macrophylla, as well as in vegetable fruits like Brussels sprouts, cabbage, cauliflower, beets, cabbage, carrots, celery, bell peppers, chili peppers, and peanuts. Other products like olive oil and red wine, as well as plants such as Impatiens noli-tangere, thyme, Plantago asiatica, and Achyranthes bidentata, also contain luteolin.

Extraction Processes

The extraction processes for luteolin can be broadly categorized into two types: traditional extraction processes and novel extraction techniques. The latter can be divided into direct extraction and extraction after raw material pre-processing. The former includes ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, and ionic liquid-assisted extraction. The latter encompasses enzyme-assisted extraction and steam explosion pre-treatment, aiming to achieve a high yield and stable quality of luteolin. Common methods for isolating and purifying luteolin include solvent extraction, micelle-mediated extraction, resin adsorption, high-speed countercurrent chromatography, and molecularly imprinted polymer adsorption. The first two methods are suitable for enriching the extract, while the latter methods can be employed for further purification.

Function:

1. Anti-Inflammatory: presently, theanti-inflammatory exertion of luteolin is believed to be related to the inhibition of nitric oxide( NO) product and other seditious cytokines similar as TNF- α and interleukin- 6( IL- 6). It also involves the repression of protein tyrosine phosphorylation and gene expression intermediated by nuclear recap factor KB( NF- KB).

2. Anti-Allergic: Luteolin can inhibit the release of antipathetic response intercessors from IgE- intermediated mortal mast cells, including histamine, leukotrienes, prostaglandin D2, and monocyte macrophage colony- stimulating factor. Its action may be associated with the inhibition of calcium affluence and protein kinase C( PKC) translocation activation.

3. Anti-Inflammatory Demyelinating Diseases: In vitro, Luteolin Powder can cure- dependently cover oligodendrocytes against oxidative damage convinced by hydrogen peroxide, explosively inhibit macrophages' phagocytic exertion towards myelin pods, significantly reduce the generation of cellular reactive oxygen species clusters, drop the expression of iNOS protein, and at low boluses, noticeably drop macrophage- produced situations of NO.

4. Anti-Fibrosis: Luteolin can reduce the degree of liver fibrosis, lower the situations of hydroxyproline( HYP) and malondialdehyde( MDA) in liver towel, and suppress the expression of type I procollagen mRNA. In vitro, it can inhibit the proliferation and collagen conflation of hepatic stellate cells( HSC). It can also meliorate pulmonary fibrosis histopathological changes caused by bleomycin, drop lung weight indicator, significantly reduce elevated MDA and HYP situations, inhibit the expression of transubstantiating growth factor- beta 1( TGF- β1) mRNA in lung towel, and in vitro, suppress the proliferation and promote apoptosis of mortal embryonic lung fibroblasts.

5. Vascular Effects:In vivo, luteolin can inhibit the generation of rabbit corneal blood vessels convinced by vascular endothelial growth factor( VEGF), and in vitro, inhibit the survival and proliferation of mortal umbilical tone endothelial cells( HUVECs) convinced by VEGF. It can significantly inhibit the proliferation and DNA conflation of vascular smooth muscle cells convinced by platelet- deduced growth factor- BB( PDGF- BB), block the cell cycle in the G1 phase, and attention- dependently reduce the pressure of precontracted blood vessels by phenylephrine, envenom high- potassium- convinced vasoconstriction, parade arterial vasodilation goods, and its vasodilation effect isnon-endothelium dependent. Its medium is associated with the direct inhibition ofvoltage-gated calcium channels, receptor- operated calcium channels, intracellular calcium release, and activation of potassium channels, and is independent of α and β receptors.

Certificates

Yuantai Organic Bio is committed to furnishing guests with the highest- quality Luteolin Bulk Powder and services so that every consumer can enjoy natural, healthy, and high- qualityfood.However, please feel free to communicate us, and we will reply to you as soon as possible, If you have any inquiries or requirements about our products. 

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