Hydroxytyrosol Powder

What is hydroxytyrosol?

Hydroxytyrosol powder is an active ingredient in olives and acts as a highly active antioxidant in the human body. Antioxidants are bioactive molecules found in many plants, but their activities vary. Considered one of the most powerful antioxidants, it is in increasing demand. Its oxygen free radical absorption capacity is approximately 4,500,000μmolTE/100g: 10 times that of green tea, and more than 2 times that of CoQ10 and quercetin.

Professor Liu Jiankang, director of the Institute of Mitochondrial Biomedicine of the Xi'an Jiaotong University Academy of Sciences, cooperated with the Swiss DSM nutritional products company to systematically study the role of hydroxytyrosol, a polyphenol extract in olive oil, from the perspective of molecular biology. , research shows that this substance promotes mitochondrial function by promoting mitochondrial synthesis. 

They found that olive oil extract hydroxytyrosol can effectively protect oxidative damage and mitochondrial dysfunction in retinal pigment epithelial cells caused by acrolein, a toxic component of cigarettes. , its main mechanism is to induce a two-phase enzyme system with detoxification effect in cells. These results suggest that it may have a protective effect on smoking-induced retinal pigment epithelial cell degeneration, such as retinal maculopathy. The results also support that a diet rich in olive oil will be beneficial in the treatment of diseases related to mitochondrial dysfunction, such as diabetes and obesity.

The chemical name is β-hydroxyethyl-dihydroxybenzene, which is a phenolic compound. Its molecular formula is C8H10O3 and its molecular weight is 154.1632. It has two phenolic hydroxyl groups and an alcoholic hydroxyl group. It is an amphoteric molecule with both phenolic and alcoholic hydroxyl characteristics. It has a strong antioxidant effect and can effectively remove exogenous and endogenous oxides and free radicals by controlling the oxidation of many unsaturated fatty acids.

What are the benefits?

Treat thrombosis, arteriosclerosis and regulate blood lipids

Pure hydroxytyrosol has anti-aggregation effect. When the concentration is 100 mg/L, it participates in regulating proteins and exerts anti-aggregation effect. It can inhibit the adhesion activity of platelets, which makes it effective in preventing the formation of thrombus. The reason why hydroxytyrosol can fight cardiovascular diseases is closely related to its inhibition of platelet aggregation. It can inhibit the synthesis of thromboxane B and increase the production of nitrous oxide, thereby achieving an anticoagulant effect. Hydroxytyrosol has a good anti-thrombotic, atherosclerotic and blood lipid regulating effect on the treatment of cardiovascular diseases and has a good therapeutic effect on cardiovascular diseases.

Anti-inflammatory effect

The effect of hydroxytyrosol on LPS-induced THP-1 cells significantly reduces the number of cells with NF-kB DNA-binding transcriptional activity, and inhibits the transcription of tumor necrosis factor-α-inducible epoxy cyclooxygenase-2 ( COX-2) and nitric oxide synthase (i-NOS) gene expression and the inhibition of COX-2 and iNOS are key to inhibiting inflammation, and further research on the anti-inflammatory mechanism is needed.

Anti-pathogenic microorganism effect

It has the characteristics of broad spectrum, and its activity against Gram-positive bacteria is also higher than that of Gram-negative bacteria. The antibacterial activity is not only strong against harmful bacteria in the intestines, but also against thermophilic lactobacilli and bifidobacteria. The effects on various other pathogenic microorganisms require further study.

Hypoglycemic effect

The hypoglycemic effects and mechanisms are gradually discovered and studied. The hypoglycemic effect of hydroxytyrosol can cause the loss of antioxidant enzyme activity, which is a fundamental solution to hyperglycemia and is a major discovery.

Prevention and treatment of cardiovascular and cerebrovascular diseases

It has obvious blood-lipid-lowering effect. It is also speculated that the effect of hydroxytyrosol in lowering blood cholesterol may be by delaying the lipid oxidation process and increasing the activity of antioxidant enzymes, thereby reducing serum cholesterol levels, triglycerides and low-density lipoprotein cholesterol.

Related experiments on the anti-inflammatory and anti-aging effects of hydroxytyrosol on human dermal fibroblasts (HDFs)

Bulk hydroxytyrosol powder is found in olive leaves and oil as oleuropein. The antioxidant and anti-inflammatory effects of hydroxytyrosol have been reported in the fields of food, medicine, pharmaceuticals and life sciences. However, it has not yet been studied in the field of skin biology. The researchers demonstrated this using a UVA-induced cellular senescence model in human dermal fibroblasts. Through this study, researchers demonstrate that hydroxytyrosol has anti-inflammatory and anti-aging effects on UVA-damaged human dermal fibroblasts. Researchers believe that hydroxytyrosol is fully worthy of use as a cosmetic material, which can effectively anti-inflammatory and delay cell aging on human dermal fibroblasts.

Skin aging is a phenomenon in which cells are unable to regenerate or function properly due to cell loss or functional degradation. Aging has multiple biological, chemical, and physical causes; skin aging due to continued exposure to ultraviolet radiation is known as cutaneous photoaging. Exposure of skin to high levels of UV rays results in direct cytotoxicity and subsequent apoptosis. When UV rays are irradiated onto cultured fibroblasts or living tissue, matrix metallopeptidase (MMP) expression increases and collagen production decreases; this ultimately damages the connective tissue in the dermis. Sustained exposure to UVA affects a wide range of organisms, not only damaging human dermal fibroblasts but also affecting cell survival and growth and inducing protein denaturation, pigmentation, and the production of reactive oxygen species. In addition, some research results show that UVA and UVB can damage DNA and produce reactive oxygen species, inducing apoptosis, which directly or indirectly causes inflammatory responses. If this reaction develops in the skin for a long time, inflammatory factors will be excessively secreted and destroy normal tissues and cells, thereby becoming a causative factor in diseases such as cancer, hypertension, diabetes, and heart disease. In recent years, people have been actively researching natural active ingredients and traditional medicines to treat stubborn skin diseases and inhibit the chronic development of inflammatory skin diseases. These studies are used as a reference for the production of cosmetics and nutraceuticals.

In recent years, olives have been widely studied and utilized in many fields. In addition to their antioxidant effects, they can strengthen the immune system and increase energy levels. They are reported to be effective in treating respiratory diseases and skin diseases. Wound infections and relief of cold symptoms. Olive leaf is considered the best polyphenol complex, with a balance of super polyphenols such as hydroxytyrosol, tyrosol, caffeic acid and oleuropein. DHPEA-EDA (hydroxytyrosol), also found in olive oil, is reported to be more effective in protecting red blood cells from oxidative damage than other ingredients. Studies on the inflammatory effects of hydroxytyrosol discuss its anticancer effects on colon and breast cancer, its preventive and neuroprotective effects on osteoarthritis, and its inhibitory effects on oxidative stress and infectious mediators. Additionally, a skin-related study examined the photoprotective and anti-melanogenic effects of phenolic compounds contained in olive leaf extract on HaCaT cells.

Application

Bulk hydroxytyrosol powder has anti-inflammatory effects, dilates blood vessels and antibacterial effects, and can prevent atherosclerosis; because hydroxytyrosol has strong antioxidant activity, it has great medical prospects. Hydroxytyrosol is a tyrosol metabolite also found in olive oil that contains strong antioxidant properties.

Hydroxytyrosol is also widely used in cosmetics due to its powerful antioxidant effect

Hydroxytyrosol supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality pure hydroxytyrosol powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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