Gardenoside

What is gardeniposide?

It is an organic compound with the molecular formula C17H24O10. This product is extracted and refined from the dried and mature fruits of the Rubiaceae plant Gardenia using high-tech production technology. It is an iridoid glycoside compound with synonyms of geniposide, geniposide and dehydroxygardeniposide. The pure product is white powder with specific rotation [α]D20+7.5° (water). Easily soluble in water, soluble in ethanol, insoluble in petroleum ether. It has a variety of uses and can be fermented under different conditions to produce natural edible colorants gardenia blue and gardenia red. It is also an raw material drug used to treat cardiovascular, cerebrovascular, hepatobiliary and other diseases as well as diabetes.

It is a major iridoid glycoside extracted from the traditional Chinese medicine Gardenia. It has many beneficial effects such as anti-cardiovascular disease, anti-inflammation, anti-diabetes, anti-skeletal muscle fibrosis, neuroprotection, hepatoprotective, choleretic, and hypolipidemia. Function. Whether hypercholesterolemia can be ameliorated by modulating bile acid metabolism in mice is unknown. To this end, the team conducted a series of experiments, and the research proved that gardeniposide regulates cholesterol metabolism by regulating the FXR-mediated hepato-intestinal crosstalk of bile acids, thereby exerting its anti-atherosclerotic function and providing a new basis for atherosclerosis and atherosclerosis. Cardiovascular disease offers a new treatment strategy.

What are the benefits?

hypoglycemic effect

 Animal experiments have confirmed that as the main active ingredient of gardenia, it also has a good effect in preventing and treating diabetes. Its mechanism is related to protecting pancreatic beta cells, activating peroxisome proliferator-activated receptor γ (PPARγ) and glucagon-like peptide 1 (GLP-1) receptor.

Activate PPARγ receptor

PPARγ is mainly expressed in adipose tissue and protects muscle, liver and pancreatic β-cells from the effects of high concentrations of free fatty acids by increasing the uptake and storage of free fatty acids in adipose tissue.

Yan Jing'en et al. found that gardeniposide can activate and increase the activity of peroxisome proliferator receptor γ (PPARγ receptor), thereby enhancing the response of downstream genes to insulin, reducing the load of compensatory insulin secretion by pancreatic islet β cells, and slowing down the islet metabolism. β-cell apoptosis, thus preventing the transformation and development of type Ⅱ diabetes to type Ⅰ multi-organ failure diabetes.

glucagon-like peptide-1 receptor signaling pathway

Glucagon-like peptide-1 (GLP-1), its main physiological effects include increasing glucose-dependent insulin secretion and inhibiting glucagon release, thereby exerting its good hypoglycemic effect.

It can promote insulin secretion by activating the glucagon-like peptide-1 receptor signaling pathway, thereby lowering blood sugar and improving symptoms of lipid metabolism disorders. Studies have shown that the iridoid gardeniposide is a GLP-1 receptor agonist through high-throughput screening, and that gardeniposide has similar neurotrophic and neuroprotective functions. Other research reports have shown that glucagon-like peptide 1 receptor plays a key role in INS-1 cells regulating insulin secretion by gardeniposide. Activate GLP-1R, then regulate Ca2+ concentration or change energy metabolism balance through signaling pathways, that is, change ATP ratio, and further regulate ATP-sensitive K+ channel activity.

It has a protective effect on neurons damaged by cerebral ischemia, and its main action pathway is to promote astrocytes and other cells to produce basic fibroblast growth factor (bFGF). Other researchers have found that gardeniposide and different contents of gardenia extract have varying degrees of protective effects on endothelial cell oxidative stress damage, and as the content increases, the oxidative stress protective effects are enhanced to varying degrees. This shows that there is a certain pharmacodynamic correlation between gardeniposide and gardenia in the protective effect of endothelial cells against oxidative stress. In addition, it can also produce a certain protective effect by reducing the activity of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) in brain tissue after cerebral ischemia and reperfusion. Reducing the content of monocyte chemoattractant protein-1 (MCP-1) in brain tissue after ischemia may also be one of the mechanisms of gardeniposide in treating cerebral ischemia.

Application direction

pigment

Under the action of β-glucosidase, gardenia glycoside undergoes a polymerization reaction with primary amino acids (glycine, lysine, and phenylalanine) to form gardenia blue. Phycocyanin extracted from gardenia blue and spirulina are the only two natural blue pigments currently available. Their properties are relatively stable and have been widely used.

medicine

Genipin a wide range of pharmacological effects, such as hepatoprotective, choleretic, anti-inflammatory, anti-thrombotic, anti-fibrosis, treatment of diabetes and neurodegenerative diseases, etc., especially in the prevention and treatment of various experimental liver diseases, it has gained more and more attention. attention and has good clinical application prospects.

Gardeniposide supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk gardeniposide Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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