Formononetin Powder

What is formononetin?

The isoflavonoid compound Formononetin (FMN, 7-hydroxy-4′-methoxyisoflavone), also known as formononetin and formononetin, is widely found in astragalus, licorice, kudzu root, and red Among leguminous plants such as Trichophyton, it is easily soluble in methanol, ethyl acetate, ether, and dilute alkali solutions, but is difficult to dissolve in water. Modern pharmacological research shows that formononetin has anti-tumor, hypolipidemic, anti-arrhythmic, antibacterial, antispasmodic, anti-lipid peroxidation, estrogen, etc. effects, can improve atherosclerotic lesions, and can also scavenge oxygen. Free radicals, inhibiting the proliferation of vascular smooth muscle cells and other functions, it is widely used in clinical practice and has significant curative effect.

Formononetin Powder is an isoflavonoid phytoestrogen, which is the main active component of the leguminous plant red clover. It can be extracted and purified through extraction, ultrasound, microwave, supercritical, subcritical water, pressurization and other pharmaceutical methods. The method is obtained from natural plants, and can also be synthesized and reconstructed through artificial methods. Many studies have shown that formononetin has good inhibitory effects on various malignant tumors such as breast, prostate, bladder, lung, endometrium, ovary, etc. Therefore, this natural product has important research value in the field of cancer prevention and treatment. Formononetin is a type of phytoestrogen rich in the natural plant red clover and the traditional Chinese medicine astragalus. It has pharmacological effects such as lowering blood pressure, regulating inflammatory responses and lipid metabolism.

What are the benefits?

Estrogen-like effects

Formononetin has estrogen-like effects due to its structural similarity to diethylstilbestrol. As a phytoestrogen, formononetin can regulate hormone levels in the body in both directions, so it has obvious efficacy in treating diseases caused by estrogen deficiency. High doses of formononetin have estrogen-like effects in the body and are safe for the reproductive system.

Effects of formononetin on cardiovascular and cerebrovascular systems

Modern pharmacological research shows that formononetin can significantly reduce the levels of cholesterol, triglycerides, and low-density lipoprotein-cholesterol in the blood, increase the content of high-density lipoprotein-cholesterol, and regulate blood lipid metabolism in the body.

Anti-oxidize effect

Oxygen free radicals (ORF) are by-products of body metabolism and have strong oxidative effects, among which ·OH has the most active chemical properties. If the oxygen free radicals generated in the human body cannot be removed in time, they will cause irreversible damage to tissues and cells. Many plant extracts have been reported to have antioxidant activity, such as polyphenols, alkaloids, and flavonoids. In previous studies, it was found that formononetin has a significant inhibitory and scavenging effect on superoxide anion free radicals and hydroxyl radical ·OH in the in vitro reaction system. Experiments have shown that formononetin can effectively enhance the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in mouse in vivo models. It can also reduce the generation of oxygen free radicals. Therefore, formononetin may exert anti-cancer effects in vivo and in vitro by scavenging harmful oxygen free radicals and increasing the body's antioxidant capacity. In addition, from the perspective of molecular structure and thermodynamics, it was revealed that the active site of formononetin that exerts antioxidant effects is the B ring in the structural formula, and the main mechanism is hydrogen atom transfer (HAT).

Regulates gene and protein expression and acts on signal transduction pathways

Phytoestrogens can play a role in multiple metabolic pathways in the human body. Studies have shown that formononetin can inhibit the key cell cycle regulatory proteins CyclinA, CyclinD1, CyclinE and PCNA by regulating the expression of related genes and proteins, activate the apoptosis-related proteins Bcl-2 family and Caspase family, and inhibit matrix metals. Proteases (matrix metalloproteinases are a type of zinc-dependent endopeptidase that can degrade various components in the extracellular matrix that hinder cell migration and provide conditions for cancer cell metastasis) and ribosomal S6 protein kinase, which directly or indirectly inhibit Cell proliferation, promoting cell apoptosis, and inhibiting tumor migration and metastasis.

Regulate human immune function and improve internal environment

Formononetin Powder has preventive and health-care effects such as protecting the body from damage, reducing serum LDL cholesterol, improving bone density, regulating hormone secretion, and benignly regulating the human body's internal environment and homeostasis, which may be important for its role. One of the mechanisms. For example, formononetin can effectively inhibit the expression of FOXA1 and GATA-3 proteins in estrogen-dependent endometrial cancer cells, thereby reducing the level of estrogen receptors, improving the endocrine microenvironment in the body, thereby improving patient prognosis. In addition, the anti-inflammatory effect of formononetin can help the body remove metabolic waste, keep the body in a good environment suitable for normal cell metabolism, and enhance the body's immunity against cancer cells.

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Yuantai Organic Bio is committed to providing customers with the highest-quality bulk Formononetin Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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