dipotassium glycyrrhizinate powder

What is dipotassium glycyrrhizinate?

Derived from a common medicinal material - licorice. Dipotassium glycyrrhizate powder is potassium glycyrrhizinate extracted from licorice roots. The raw material is white powder. It is a skin conditioner and a moisturizer that can soothe sensitivity, repair damage, resist inflammation and whiten. Clinical trials have shown that it can also effectively deal with dermatitis. At the same time, it is also a natural sweetener with anti-inflammatory, anti-viral, liver-protecting, detoxifying and immune-enhancing effects. According to food additive standards, dipotassium glycyrrhizinate can be used as a sweetener in flour products.

Dipotassium glycyrrhizinate is a derivative of glycyrrhizic acid and belongs to the triterpene saponin class. Its molecular formula is C42H60K2O16. It has a special sweet taste, good water solubility and pure taste. Dipotassium glycyrrhizinate is extracted from the roots of the leguminous plant licorice and has been developed and used in many fields. It has antibacterial, anti-inflammatory, detoxifying, anti-allergic, deodorizing and other effects. It is widely used in medicine, cosmetics, daily chemicals, food and other industries.

As a derivative of glycyrrhizic acid, dipotassium glycyrrhizinate is a white powder with a sweet taste, low caloric energy, low foaming and hemolysis, and can be dissolved in water and dilute ethanol. As a skin conditioner, dipotassium glycyrrhizinate is anti-inflammatory, anti-allergic, and antibacterial. It also has the functions of soothing the skin and moisturizing. The anti-inflammatory effect of 0.5% dipotassium glycyrrhizinate solution is as good as that of 0.1% Dexamethasone (a synthetic glucocorticoid drug with powerful anti-inflammatory effects) is equivalent and has no serious adverse reactions.

Dipotassium glycyrrhizinate powder benefits

Anti-inflammatory repair

Dipotassium glycyrrhizinate powder reduces and subsides inflammation by controlling the production of inflammatory factors, while repairing skin barrier damage caused by inflammation. The anti-inflammatory effect of 0.5% dipotassium glycyrrhizinate solution is equivalent to that of 0.1% dexamethasone without serious adverse reactions.

Dipotassium glycyrrhizinate can reduce the inflammatory response of tissues and inhibit the release of inflammatory mediators, thereby having a certain therapeutic effect on inflammation-related diseases. It can soothe skin discomfort and help promote skin healing and repair.

Soothing and anti-allergic

 As a skin conditioner, dipotassium glycyrrhizinate is anti-inflammatory, anti-allergic, and antibacterial. It also has calming, soothing, and moisturizing effects. It has a good effect on relieving redness and itchiness of the skin and helps restore the skin. Barrier function, improve skin immunity.

Assisted whitening

Dipotassium glycyrrhizinate can form a self-defense barrier on the skin from the root to prevent and reduce skin problems such as tanning, spots, and acne. It can also whiten the skin and form a natural barrier against ultraviolet rays on the skin.

Dipotassium glycyrrhizinate can also inhibit the production of melanin and has a good whitening effect.

Antibacterial effect

Dipotassium glycyrrhizinate can inhibit the growth of certain bacteria and fungi

Anti-oxidize effect

Dipotassium glycyrrhizinate can scavenge free radicals, reduce oxidative damage, resist oxidative stress, and delay aging.

Anti-inflammatory and anti-allergic

By acting on hormone receptors on the cell membrane, it affects ion channels, activates or inhibits enzyme activity, regulates substance metabolism and the excitability of cholinergic nerves, thereby reducing the permeability of capillary walls and cell membranes, thereby reducing inflammation. The purpose of exudation is to inhibit the formation and release of histamine and other toxic substances, thereby achieving a good anti-inflammatory effect.

When LPS stimulates RAW264.7 cells, it can inhibit the secretion of inflammatory mediator NO and inflammatory cytokine IL-6 by the cells to varying degrees.

Therefore, in cosmetics, it can help reduce skin redness, swelling, irritation and allergies common in various diseases such as rosacea and psoriasis. Other clinical trials have shown that dipotassium glycyrrhizinate can effectively treat atopic dermatitis.

Modulate immune function

It has mineralocorticoid-like effects - sodium retention and potassium excretion and glucocorticoid-like effects - sugar metabolism, but there are no side effects with long-term use.

Direct effect: It is generally believed that the chemical structure of glycyrrhetinic acid in dipotassium glycyrrhizinate is similar to that of adrenocortical hormone (Cortin). It affects ion channels and activates or inhibits enzymes by acting on the hormone receptor (Receptor) on the cell membrane. Activity, regulates substance metabolism, and regulates the excitability of cholinergic nerves. As a result, the permeability of capillary walls and cell membranes is reduced, inflammatory exudation is reduced, and the formation and release of histamine and other toxic substances are inhibited, thereby achieving a good anti-inflammatory effect.

Indirect effect: that is, the glycyrrhetinic acid in dipotassium glycyrrhizinate inhibits the destruction of adrenocortical hormones in the body, thereby increasing its content in the blood, thereby enhancing the body's resistance to inflammation.

Anti-allergic effect

It has a good anti-allergic effect and has a good effect on inhibiting histamine production and skin redness and itching, especially it has a significant protective effect on certain anaphylactic shocks. The basic unit between the stimulus that causes itching and the impulse that occurs in free nerve endings is a physiologically active mediator. Histamine is the material basis of itching. Any factors that stimulate mast cells can degranulate the mast cells and release histamine, thus causing itching. Therefore, antihistamines and drugs that stabilize mast cells and reduce histamine release can be used clinically to treat common itching. As a common complication of skin sensitivity, itching has main allergens and pathways of action similar to allergic reactions. Experiments have proven that , Dipotassium glycyrrhizinate inhibits the occurrence of type I hypersensitivity reactions and can largely reduce the onset of itching.

Application direction

In the field of cosmetics, dipotassium glycyrrhizinate can be used in sunscreen, toner, facial cream, facial cleanser, lipstick, eye cream, hair conditioner and other cosmetics to meet consumers' demand for high-quality, high-function cosmetics. It can also be added to toothpaste as an anti-inflammatory agent. In addition, it can be used as a sweetener and flavoring. 

At the same time, dipotassium glycyrrhizinate can also be combined with other active ingredients to enhance its efficacy and stability. It should be noted that the concentration, dosage and compatibility requirements of dipotassium glycyrrhizinate need to be scientifically and reasonably designed and controlled based on the specific product and manufacturing process to ensure its safety and effectiveness, while meeting the requirements of relevant regulations and standards.

scope

In the medical field, dipotassium glycyrrhizinate can be used in eye drops and ointments;

In the cosmetics industry, it can be used for sunscreen, freckle removal cream, skin care lotion, lotion, etc.;

In the daily chemical industry, it can be used in toothpaste;

In the food industry, it can be used as potassium supplement, sweetener, preservative, and flavoring agent for sports drinks.

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