Bulk Ursolic Acid

What is Ursolic Acid?

Bulk Ursolic Acid powder is a pentacyclic triterpenoid compound extracted from the bearberry, an evergreen shrub of the Ericaceae family. It has a special smell. It can be obtained in the form of large and shiny prisms in absolute ethanol, and in dilute ethanol. Needle crystals as thin as hair. mp285℃～288℃, [α]D20+66° (pyridine), easily soluble in dioxane, pyridine, soluble in methanol, ethanol, butanol, butanone, slightly soluble in acetone, slightly soluble in benzene and chloroform , diethyl ether, insoluble in water and petroleum ether. It has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. In addition, ursolic acid has obvious antioxidant function and is a strong antioxidant. 

The antioxidant effect of ursolic acid has a positive effect on the human body's anti-aging, skin freckle removal, and pigment removal, so it is widely used as Medical and natural whitening cosmetic raw materials. Experiments have shown that ursolic acid can inhibit the activity of 5-lipoxygenase and cyclooxygenase during the metabolism of arachidonic acid, and prevent the production of prostaglandins and leukotrienes. This may be due to ursolic acid. Suppress inflammatory response and inhibit lipid peroxidation.

Plant source

Bulk Ursolic Acid is widely distributed in the plant kingdom. For example, the traditional Chinese medicine hawthorn, dogwood, hedyotis diffusa, gardenia, plantain, and prunella vulgaris all contain ursolic acid. It is distributed in free form or in the form of glycosides combined with sugar. There are about 62 species of plants in 46 genera and 7 families, mainly the leaves of Ligustrum lucidum of Oleaceae, the bearberry of Rhododendron, the leaves of Locust plant of Rosaceae, the leaves of Paulownia tomentosa of Scrophulariaceae, and the whole plant of Prunella vulgaris of Lamiaceae. Grass, leaves of Ilex genus Ilex in the family Ilex, etc.

Extraction Method

The crushed loquat leaves or Ligustrum lucidum leaves are refluxed and extracted with ethanol to obtain a liquid extract, and the ethanol is recovered. The above extract is fully washed with water and dried to obtain a dry extract. The dry extract is dissolved in ethanol and decolorized. After recovering the ethanol, add water to precipitate a large amount of precipitate, adjust the pH value to 2-2.5, separate and collect the precipitate, wash it with water until neutral, and dry it in a vacuum to obtain a crude extract whose main component is ursolic acid.

What are the benefits?

It has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, lowering blood sugar, etc. Ursolic acid also has obvious antioxidant function, so it is widely used as a raw material for medicine and cosmetics.

Liver protection and anti-inflammatory

The clinical manifestations of ursolic acid are that it can significantly and rapidly reduce alanine aminotransferase and serum aminotransferase, subside jaundice, increase appetite, resist fibrosis and restore liver function. It has the characteristics of quick effect, short course of treatment and stable effect.

Anti-oxidation

Ursolic Acid powder is a powerful antioxidant. Experiments have shown that ursolic acid can inhibit the activities of 5-lipoxygenase and cyclooxygenase during the metabolism of arachidonic acid, and prevent the production of prostaglandins and leukotrienes. This may be because ursolic acid inhibits inflammatory reactions and inhibits lipid metabolism. cause of oxides. Subbaramaiah et al. have shown that ursolic acid can inhibit the transcription of cyclooxygenase in human mammary epithelial cells, thereby inhibiting prostaglandin production. The antioxidant effect of ursolic acid has a positive effect on the human body's anti-aging, skin freckle removal, and pigment removal.

Antibacterial and antiviral

Tapondjou et al. confirmed through acetic acid twisting test and hot plate test that ursolic acid and hydroxyursolic acid have similar anti-inflammatory and antibacterial effects. Ursolic acid can inhibit the production of superoxide induced by formylmethionyl-leucyl-phenylalanine (fMLP) and arachidonic acid respectively. When ursolic acid and fMLP were added to the cell culture medium, ursolic acid inhibited the tyrosine phosphorylation of 45ku protein induced by fMLP in a dose-dependent manner. Ursolic acid also has trypanocidal activity. After incubation for 2 hours at a concentration of 2 g·L, the activity of Trypanosoma cruzi flagellates was completely inhibited.

Anti-atherosclerosis

Rosemary extract ursolic acid can reduce blood cholesterol (44%) and B-lipoprotein levels (50%) in rabbits and rats, and has blood lipid-lowering and anti-atherosclerotic effects. Ursolic acid can improve liver and kidney yin deficiency, tinnitus, dry mouth, insomnia, irritability, numbness in limbs, cold sensitivity, and constipation caused by dyslipidemia. The total effective rate of blood lipid efficacy is 95%.

Suppress HIV

Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). Tian Ying et al. demonstrated through clinical trials that ursolic acid has a strong inhibitory effect on HIV-1 protease activity, and its 50% inhibitory concentration (IC50) is 8 μmol/L. HIV-1 protease is a homodimer enzyme. Ursolic acid may inhibit the activity of HIV-1 protease by inhibiting the dimerization of HIV-1 protease, thereby inhibiting the function of HIV protease.

Ursolic acid and its malonic acid derivatives can inhibit HIV-1 protease with (IC50) of 8 and 6 μmol/L respectively.

Ursolic acid and alpha-arbutin

Ursolic Acid powder is a powerful antioxidant. Experiments have shown that ursolic acid can inhibit the activities of 5-lipoxygenase and cyclooxygenase during the metabolism of arachidonic acid, and prevent the production of prostaglandins and leukotrienes. This may be because ursolic acid inhibits inflammatory reactions and inhibits lipid metabolism. cause of oxides. Subbaramaiah et al. have shown that ursolic acid can inhibit the transcription of cyclooxygenase in human mammary epithelial cells, thereby inhibiting prostaglandin production. The antioxidant effect of ursolic acid has a positive effect on the human body's anti-aging, skin freckle removal, and pigment removal. Among the 29 Japanese patents on ursolic acid from 1983 to 2004, 10 were about the application of ursolic acid in skin beauty and health care. As a cosmetic, ursolic acid has stable properties, the color and smell do not change over time, and it has It has a good touch feeling, so it is widely used in beauty and skin care products. It is a natural whitening cosmetic raw material.

α-Arbutin can repair skin damage caused by ultraviolet rays and restore the transparency of the skin. It is not easily decomposed by β-glucosidase on the skin surface. The effect is about 10 times that of β-arbutin and can stay on for a long time. Every corner of the skin is continuously protected from damage. Melanin is the cause of skin dullness. α-Arbutin can quickly penetrate deep into the skin and inhibit the activity of tyrosinase in the pigment mother cells deep in the stratum corneum. And it forms a dual effect on the surface of the skin, inhibiting the production of melanin.

Comparison of whitening principles

Arbutin: Arbutin reduces the production of melanin by inhibiting the activity of tyrosinase, an enzyme that produces melanin. Its principle of action is similar to the whitening drug hydroquinone. (safety critical concentration 7%)

Ursolic acid: Ursolic acid has a positive effect on the human body's anti-aging, skin freckle removal, and pigment removal through its antioxidant effect.

α-Arbutin: α-Arbutin can quickly penetrate deep into the skin and inhibit the activity of tyrosinase in the chromoblasts deep in the stratum corneum. And it forms a dual effect on the surface of the skin, inhibiting the production of melanin.

Application direction:

Ursolic acid has various biological functions such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and hypoglycemic. Ursolic acid has obvious antioxidant effects and is widely used in medicine, cosmetics and other fields.

1. Pharmaceutical and health care industry

Research by Tan Renxiang and others has also confirmed that ursolic acid not only has the effect of treating viral hepatitis, but also has antidepressant effects. Perilla extract containing ursolic acid is used as a drug to treat depression, with almost no adverse reactions. Compared with Western medicine has significant advantages such as its narrow antidepressant spectrum, high toxic and side effects, easy relapse and suicidal tendencies after use. Ursolic acid is in the form of shiny prismatic crystals (absolute ethanol) or fine hair-like needle crystals (dilute ethanol) in high content, and in low content it is brown or yellow-green powder with a special odor. It is a compound that exists in natural plants. Pentacyclic triterpenoids.

2. Daily chemical industry

Rosemary extract ursolic acid can prevent and treat dermatitis, rough skin, dryness, whitening, prevention and moisturizing in skin beauty and health care, and is widely used in beauty and skin care products.

3. Food industry

Fruits rich in ursolic acid such as pomegranates, hawthorns, loquats, green plums, blueberries, etc. are very popular among people, and fruit wines and beverages produced from them are also popular for their unique taste and health benefits to the human body. 

Bulk Ursolic Acid Supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality Bulk Ursolic Acid Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

Package & Shipment

Our Company and Factory

Hot tags:Bulk Ursolic Acid,Bulk Ursolic Acid powder,Ursolic Acid powder,Suppliers, Manufacturers, Factory, Buy, price, for sale, producer, free sample, OEM, ODM, private label, white label.