Bulk Glycyrrhetinic Acid

Product details?

Licorice (Glycyrrhize glabra L.) is a common medicinal and edible food. Licorice extract is widely used in candies and canned foods as a natural sweetener. The sweet taste of licorice comes from glycyrrhizic acid and glycyrrhetinic acid. The former is a type of triterpenoid saponin, accounting for about 4% to 5% of the dry weight of licorice root. Its sweetness is 50 times that of sucrose. It is formed by hydrolyzing the sugar acid chain of glycyrrhizic acid, and its sweetness is 250 times that of sucrose. times. It is cytotoxic. Long-term consumption of large amounts of licorice (100g/d) can cause severe hypertension and cardiac hypertrophy. Clinical symptoms include sodium ion retention and potassium ion excretion. In severe cases, it can lead to extreme weakness and ventricular fibrillation.

The main active component of licorice is glycyrrhizic acid. The molecular structure of glycyrrhizic acid contains 1 molecule of glycyrrhetinic acid (Glycyrrhetinic Acid) and 2 molecules of glucuronic acid. In recent years, pharmacological and clinical studies have found that glycyrrhizic acid has hepatoprotective, anti-inflammatory, antihypertensive, enhanced body immunity, and improved physiological functions. It has anti-inflammatory, antioxidant, antibacterial, antiviral and other effects. Glycyrrhetinic acid and Bulk Bulk Bulk Glycyrrhetinic Acid have many similarities in pharmacological activities. In terms of anti-inflammation, glycyrrhetinic acid and its derivatives can directly inhibit the production of inflammatory cytokines and inflammatory mediators through multiple targets, and can also Mechanisms such as enhancing the activity of steroid hormones indirectly exert their anti-inflammatory functions.

What are the benefits?

Anti-allergic and soothing effect

It is similar in structure to hydrocortisone. A large number of clinical trials have confirmed that it has good anti-inflammatory effects and can effectively inhibit the production of prostaglandin PGE2 in inflammatory tissues and antagonize inflammatory mediators such as histamine.

It can directly bind to phospholipase A2, the initiating enzyme of arachidonic acid metabolism pathway, and to lipoxygenase that acts on arachidonic acid to produce inflammatory mediators, and selectively hinders the phosphorylation of these enzymes. Inhibit its activation.

Antibacterial effect

It has strong anti-inflammatory and antibacterial effects and can inhibit the permeability of capillaries. Used in lipstick, it can prevent the rupture of brittle lips. It is also commonly used to treat mucosal diseases and can be used in oral hygiene products to prevent dental caries and mouth ulcers.

Auxiliary whitening effect

It can inhibit the permeability of capillaries and has a good therapeutic effect on red blood cells and hormone dependence. It can effectively prevent stains caused by pigmentation caused by inflammation, eliminate micro-inflammation on the skin surface, and quickly brighten the skin color. .

hormone-like effects

It has a similar structure to steroid hormones, so it can exert glucocorticoid effects in the body.

It has the effect of activating hormone receptors and enhancing its own hormones or hormones administered through drug pathways, also known as glucocorticoid effect. Its structure is different from that of steroid hormones, so there are no adverse reactions and side effects of hormones.

Anti-inflammatory and anti-immune effects

Has anti-inflammatory effects like phenylbutazone or hydrocortisone. It has an inhibitory effect on cotton ball granuloma, formaldehyde foot swelling, and subcutaneous granulomatous inflammation in rats. Its anti-inflammatory potency is about 1/10 of cortisone or hydrocortisone. It has inhibitory effects on experimental arthritis in rats caused by carrageenan, and it has varying degrees of inhibitory effects on allergic reactions in guinea pigs caused by horse serum or egg albumen. Its anti-inflammatory and anti-allergic responses may be related to inhibition of capillary permeability, antihistamines, or reduced cell responsiveness to stimuli.

Effect on digestive system

It can reduce blood bilirubin and increase urinary bilirubin excretion in rabbits and rats with common bile duct ligation. This effect is stronger than glucuronolactone or methionine. It has good anti-ulcer effect on pylorus ligated rats. Its therapeutic index is high.

Antitussive and expectorant effect

The choline salt of Bulk Glycyrrhetinic Acid has a significant antitussive effect on coughs caused by chemical stimulation (inhalation of ammonia) and electrical stimulation of the superior laryngeal nerve in cats. Therefore, it is believed that its antitussive effect is related to the central nervous system.

Antidiuretic effect

Glycyrrhetinic acid and its salts have significant antidiuretic effects. It can enhance the reabsorption of sodium and chloride by the renal tubules and exhibit antidiuretic effect; its mode of action is different from that of deoxycorticosterone, which may be due to its direct effect on the renal tubules.

Effects on inner ear auditory function

Studies using auditory electrophysiology methods have shown that after intramuscular injection of 100 mg/kg into guinea pigs, the action potential response threshold of the guinea pig's auditory nerve decreases, indicating that it has the effect of improving the auditory function of the inner ear of guinea pigs.

Inhibition of acetylcholinesterase

When using a concentration of 4×10\-2mg/ml. It has a significant inhibitory effect on acetylcholinesterase, which is enhanced with the increase of drug concentration within this dose range. The drug concentration at 50% inhibition rate is 21.8±1.1mg/L. The inhibitory effect on acetylcholinesterase is a competitive-non-competitive mixed inhibition, and has a similar inhibitory effect to neostigmine.

Scavenging effect on oxygen free radicals

18-β-glycyrrhetinic acid 0.3mmol/L has a significant scavenging effect on oxygen free radicals released by human polymorphonuclear leukocytes (PMN), but has no effect on the oxygen consumption of PMN. 18-β Glycyrrhetinic acid has an obvious scavenging effect on O-2 and -OH produced in aqueous solution systems. 30mol/L has a significant inhibitory effect on the chemiluminescence produced by PMN. The results confirmed that 18-β glycyrrhetinic acid can directly capture oxygen free radicals.

Application direction

1. Sweetener; sweetness improver; flavoring agent (used in conjunction with salt, the effect is particularly great); flavor enhancer (used to remove the smell of dairy products, cocoa products, egg products, mutton, etc.). Chinese folk customarily use it in sauces, sauce products, pickled products, etc.

2. Antibiotic drugs, used to treat infections caused by Staphylococcus, Streptococcus, Escherichia coli, Helicobacter, etc.

3. It is an important raw material for medicine and high-end cosmetics. It has anti-inflammatory and anti-allergic effects, inhibiting bacterial reproduction, etc.

Certificate

Yuantai Organic Bio is committed to providing customers with the highest-quality Bulk Glycyrrhetinic Acid Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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