Betulinic acid Powder

What is Betulinic acid powder?

Betulinic Acid Powder is a white crystalline powder with a slight smell and a bitter taste, which is a naturally occurring pentacyclic triterpene. It was first found in the bark of evergreen plants of the Rhamnaceae family in East Africa. Now it can be obtained from It is extracted from leaves of cattail, the bark of Betula platyphylla and the fruit of wild jujube and so on, but the main source is extracted from birch bark. It has anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties, especially for melanoma, it has a good effect and does not kill healthy cells, so it is the most promising anticancer drug precursor.

Chemical Name	3β-hydroxy-lup-20(29)-ene-28-oic acid
Appearance	White Crystalline Powder
Specification	70%, 80%, 90%, 95%, 98%
CAS No.	472-15-1
Molecular Formula	C30H48O3
Solubility	Insoluble in water, slightly soluble in methanol, ethanol, acetone, and easily soluble in tetrahydrofuran and pyridine.
Molecular Structure

What are the benefits of Betulinic acid powder?

1) Anti-tumor effect

It was first discovered that it can selectively kill human melanoma cells but not healthy cells. In recent years, it has also been found to have a strong broad-spectrum activity on other tumor cells.

2) Anti-inflammatory effect

It can inhibit the production of PGE2 and reduce inflammation. Its anti-inflammatory properties may depend on the inhibitory effect of protein kinase C without involving any neurogenic inflammatory mechanism.

3) Antiviral effect

It has relatively prominent antiviral activity, especially anti-HIV activity.

4) Anti-hyperlipidemic effect

Studies have found that it and its derivatives can exert anti-hyperlipidemia effects through mechanisms such as regulating adipokines, reducing lipid production, and reducing triacylglycerol and total cholesterol levels.

5) Anti-diabetic effect

It has shown good efficacy in the treatment of diabetes, mainly by inhibiting α-amylase and α-glucosidase to reduce the hydrolysis of polysaccharides and promote glycogen synthesis.

Processing Methods

1）Extractiion from Natural Plants

It exists in many plants, , so we can use different extract solvents to get BA from different plants. This method is simple, but the content in plants is very small, then it needs a lot of raw materials, and it many impurities, the yield is low, so it is rarely used, and it is often only used as a by-product of Betulin.

2) Synthesized with Betulin as a Precursor

This method is obtained by a series of chemical reactions in Betulin from natural plant. The content of betulin in plants is relatively high. At present, it is obtained through direct extraction, and the extraction cost is relatively low. Therefore, it can reduce the cost, and it is the main source of betulinic acid on the market.

3) Microbial Transformation with Betulinic as a precursor

It uses enzymes produced in the metabolic process of organisms to catalyze the reaction of betulin to obtain the target product. This method has mild reaction conditions, low pollution and low cost. This approach represents a new direction for the plant extraction industry in the future, but there are still many technical problems that have not been resolved.

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