Asiaticoside powder

What is Asiaticoside?

Asiaticoside powder is one of the main components of triterpene saponins in Centella asiatica extract powder, and its molecular formula is C48H78O19. Modern pharmacological research has confirmed that asiaticoside has anti-inflammatory, inhibiting scar formation, promoting wound healing, neuroprotection, anti-anxiety, immune regulation and other effects.

Asiaticoside is a white needle-shaped crystal extracted from Centella asiatica. Studies have shown that asiaticoside can inhibit the proliferation of fibroblasts, reduce transamidase activity, reduce the amount of acidic mucopolysaccharides and collagen, and inhibit the excessive proliferation of the matrix and fiber components of connective tissue. Experiments have shown that it can promote skin growth, local cell proliferation, connective tissue and vascular network proliferation, and increase mucus secretion.

Asiaticoside is an organic compound with the molecular formula C48H78O19. The pure product is a white needle crystal, and the industrial product is a light yellow to light brown powder; odorless, bitter, and slightly hygroscopic. Easily soluble in water and ethanol, but insoluble in ether and chloroform. Specific optical rotation [α] 22D-14.4 (ethanol). It is mainly extracted from the dried whole plant of Centella aslatica (L.) Urb. Promotes wound healing. Used to treat trauma, surgical wounds, burns, keloids and scleroderma.

What are the benefits?

Asiaticoside powder is a natural skin care ingredient with multiple effects such as antioxidant, anti-inflammatory, anti-aging, whitening and repairing. It can promote the synthesis of collagen, increase skin elasticity, reduce the appearance of wrinkles and fine lines, and delay the aging process of the skin. At the same time, asiaticoside can also inhibit the activity of tyrosinase, reduce the production of melanin, fade dark spots and stains, brighten the skin color, and make the skin brighter and more even.

In addition to its whitening and anti-aging effects, asiaticoside also has anti-inflammatory, calming and moisturizing effects. It can reduce the skin's sensitivity to external stimuli, relieve discomfort such as skin redness, swelling and itching, and effectively improve sensitive skin problems. At the same time, asiaticoside can also provide long-lasting moisturizing effects, enhance the skin's water retention capacity, and improve the problems of dry and rough skin.

1. Anti-inflammatory mechanism

Centella asiatica extract powder Asiaticoside can improve a variety of inflammatory reactions, and its mechanism of action is related to down-regulating the expression of IL-6, IL-1β, and TNF-α in the NF-κB pathway and inhibiting oxidative stress. Research has found that, on the one hand, asiaticoside can inhibit the NF-κB signaling pathway and down-regulate the expression of nitric oxide (NO), TNF-α, and IL-6, thereby exerting anti-inflammatory effects; on the other hand, Centella asiatica Glycosides can also exert anti-inflammatory effects by regulating the heme oxygenase 1 (HO-1) signaling pathway and inhibiting the production of pro-inflammatory factors and the activity of peroxidase. Madecassoside can reduce the inflammatory response caused by hypoxic conditions by inhibiting the NF-κB/p38 signaling pathway, downregulate the expression of microribonucleic acid-155 (miR-155), and upregulate the suppressor of cytokine signaling 1 (SOCS1) ) expression to reduce the inflammatory response caused by hyperoxic conditions.

2. Mechanism of action to improve liver, lung, and kidney damage

Asiaticoside can improve liver, lung, and kidney damage, and its mechanism of action is related to inhibiting oxidative stress inflammatory response and improving antioxidant capacity. Studies have shown that asiaticoside can improve septic lung injury and septic acute kidney injury. On the one hand, asiaticoside can improve lung injury by upregulating the expression of PPAR-γ, inhibiting the activity of MAPK and NF-κB signaling pathways; on the other hand, asiaticoside can downregulate IL-6 in serum The expression of iNOS protein and the expression of iNOS protein in renal tissue play a role in improving renal injury. Asiaticoside can improve renal damage in nephropathy model rats, and its mechanism of action is related to up-regulating the mRNA expression of synaptophysin, endorphin, and podophyllin, and down-regulating the mRNA expression of desmin. The ameliorative effect of madecassoside on hyperoxia-induced lung injury was studied through in vivo and in vitro experiments. The results showed that madecassoside could reduce the levels of myeloperoxidase (MPO) and malondialdehyde (MPO) in the serum of lung injury model rats. MDA) content as well as TNF-α, IL-1β and IL-6 levels, and increase total antioxidant (TAOC) levels to improve lung injury in rats. In addition, asiaticoside can improve liver damage by inhibiting the expression of TNF-α and MAPK.

3. The mechanism of inhibiting scar hyperplasia and repairing skin damage

Asiaticoside can inhibit scar hyperplasia and repair skin damage. Its mechanism of action is related to inhibiting the expression of type I and III collagen, TNF-α, IL-6, IL-1β and the activity of Wnt/β-catenin signaling pathway, and upregulating TGF- related to the expression of β1, VEGF, iNOS and MCP-1.

Madecassoside can inhibit the proliferation of scar fibroblasts. When the drug concentration is between 0.1 and 1.0mg/ml, the proliferation of fibroblasts is significantly inhibited, suggesting that asiaticoside reduces the formation of granulation tissue and collagen by inhibiting fibroblasts. and the synthesis of extracellular matrix, thereby reducing scar formation; at the same time, asiaticoside can inhibit the expression of type I and type III collagen mRNA in scar fibroblasts when it is at 1.0mg/ml, which shows that asiaticoside can reduce collagen by production, reducing the synthesis of extracellular matrix, thereby inhibiting scar formation. It shows that asiaticoside can inhibit the function of collagen secretion by inhibiting overactive fibroblasts, thereby inhibiting collagen proliferation and interfering with scar formation.

4. Mechanism of action against Alzheimer’s disease

Asiaticoside can improve Alzheimer's disease (AD), and its mechanism of action is related to inhibiting HUVEC apoptosis, TLR4/NF-κB signaling pathway activity, and the expression of inflammatory factors IL-1, IL-6, and TNF-α. According to literature reports, asiaticoside can alleviate neuroinflammation by reducing the level of NO and the expression of iNOS mRNA in astrocytes. Asiaticoside can improve the damage of vascular endothelial cells (HUVEC) caused by Aβ, and its mechanism of action is related to inhibiting apoptosis and the expression of IL-1, IL-6, and TNF-α. The intervention effect of asiaticoside on Aβ1-42-induced apoptosis of hBMECs in human brain microvascular endothelial cells. It was found that asiaticoside can inhibit the apoptosis of hBMECs. Its mechanism of action is related to the inhibition of TLR4 and myeloid in the TLR4/NF-κB signaling pathway. The expression of differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), and p-NF-κB p65 protein is related to the nuclear transfer of NF-κB and the expression of TNF-α and IL-6. Asiaticoside can regulate the production of Aβ before neuropathy, thereby preventing the occurrence of AD. Asiaticoside has a protective effect on HUVEC damage caused by Aβ1-42, and its mechanism of action is related to up-regulating the expression of Bcl-2 and down-regulating the expression of Bax. Studies have found that asiaticoside has a significant reversal effect on AD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and its mechanism of action is related to increasing Bcl-2 /Bax ratio. Moreover, asiaticoside has strong blood-brain barrier penetration ability and has the potential to treat neurodegenerative diseases.

5. Anti-fibrosis mechanism

Asiaticoside powder can reduce the degree of fibrosis in various tissues and organs such as lungs, liver, kidneys and heart. Its mechanism of action is related to down-regulating the expression of TGF-β1, CTGF, ALT, asiaticoside T and Hyp. Relevant studies have found that when the mass concentration of madecassoside is 400 μg/mL, it exhibits an inhibitory effect on human embryonic skin fibroblasts and human lung fibroblasts. Asiaticoside can exert anti-fibrotic effects by inhibiting the production of inflammatory cytokines and reducing the expression level of TGF-β1mRNA. Asiaticoside can significantly improve renal fibrosis in unilateral ureteral obstruction model rats, and its mechanism of action is related to down-regulating the expression of renal interstitial connective tissue growth factor (CTGF) and type III collagen (ColIII); in addition, Centella asiatica Glycosides can also improve myocardial fibrosis after myocardial infarction in rats. Asiaticoside can reduce the degree of fibrosis in rat liver tissue, and significantly reduce the levels of ALT and asiaticoside T in rat serum and the level of Hyp in liver tissue, indicating that asiaticoside can improve immune liver fibrosis. effect. Asiaticoside can improve bleomycin (BLM)-induced pulmonary fibrosis in rats, and its mechanism of action is related to the regulation of the TGF-β1/Smad pathway. Another study found that asiaticoside can also significantly reduce the degree of fibrosis in the lung tissue of mice with pulmonary fibrosis model. Its mechanism of action is through activating A2AR-assisted cyclic adenosine monophosphate (cAMP)/R asiaticoside-related protein. 1 (RAP1) signaling pathway to improve pulmonary fibrosis.

6. The mechanism of improving learning and memory abilities

Madecassoside can improve the learning and memory of mice, and its mechanism of action is related to reducing the deposition of Aβ in hippocampal tissue and upregulating synaptophysin (SYN) protein expression; it is also related to upregulating peroxisome proliferator-activated γ receptors ( PPARγ) protein expression is related to down-regulating the expression of inflammatory factors IL-6, TNF-α, and IL-1. Relevant studies have found that asiaticoside also has a good preventive and therapeutic effect on cognitive dysfunction in diabetes, and its mechanism of action is related to regulating oxidative stress and the PI3K/Akt/NF-κB pathway.

Application direction

Asiaticoside powder is the main ingredient in the medicinal Centella asiatica extract powder. The mixture of asiaticoside A and asiaticoside B has pharmacological effects such as promoting wound healing, anti-wrinkle, anti-inflammation, anti-depression, and promoting intelligence. Comparing the pharmacological effects of madecassoside in promoting wound healing and treating scars, it can be found that madecassoside A and asiaticoside B play a major role in the anti-inflammatory, antidepressant, and intelligence-promoting pharmacological effects of total saponins of asiatica. effect.

Asiaticoside supplier

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