Alpha Mangostin Powder

What Is alpha mangostin powder?

Alpha mangostin powder refers to the powder form of a compound called alpha mangostin extracted from mangosteen shell. Alpha mangostin is a ketone compound that has multiple biological activities, including antioxidant, anti-inflammatory, and anti-oxidant effects.

What are the functions of alpha mangostin powder?

Anti-inflammatory

Alpha mangostin powder inhibits the activity of cyclooxygenase and sphingomyelinase, participates in regulating cell growth, differentiation, apoptosis and other processes, thereby playing an anti-inflammatory role.

Antibacterial

Alpha mangostin has strong antibacterial activity against methicillin and toluene penicillin-sensitive Staphylococcus aureus.

Antioxidant

Alpha mangostin powder has antioxidant activity, can inhibit the oxidation of low-density lipoprotein, and has potential benefits in combating cardiovascular disease and other chronic diseases.

Antioxidant effect

As a free radical scavenger, Alpha mangostin powder can protect low-density lipoprotein from oxidative damage, thereby reducing the risk of cardiovascular disease and other chronic diseases.

Anti-inflammatory and neuroprotective

In the nervous system, Alpha mangostin powderexerts multi-target neuroprotective effects on diseases such as Alzheimer's disease, depression, autism, vascular dementia, and schizophrenia by inhibiting inflammatory response, anti-oxidative stress, and anti-neuronal apoptosis.

Protective effect of alpha mangostin powder in the nervous system

The protective effect of Alpha mangostin in the nervous system is mainly reflected in its multi-target pharmacological properties, which play a positive role in maintaining and restoring the health and function of the nervous system through different mechanisms.

Inhibition of inflammatory response: Alpha mangostin can inhibit the inflammatory response of the nervous system through multiple pathways, reduce the production and release of inflammatory factors, and thus protect neurons from inflammatory damage.

Anti-oxidative stress: As a potent free radical scavenger, a-mangostin can effectively neutralize oxidative stress products in the body and reduce oxidative stress damage to neurons. Anti-neuronal apoptosis: By inhibiting the related signaling pathways of neuronal apoptosis, a-mangostin can reduce neuronal death and protect the number and function of neurons.

Protective effect in specific diseases

Alzheimer's disease (AD)

Inhibition of the formation of Aβ fibers: Alpha mangostin powder can inhibit the fibrosis and aggregation of Aβ proteins, thereby reducing the toxic effects of Aβ deposition on neurons.

Reduce the aggregation of Aβ protein: By binding to specific sites of Aβ protein, alpha mangostin can interfere with the aggregation of Aβ protein, further reducing its damage to neurons.

Reduce inflammatory damage: Regulate the activation state and behavior of microglia, reduce the production of inflammatory factors, and thus reduce inflammatory damage to the nervous system.

Anti-neuronal apoptosis: By increasing the activity and expression of heme oxygenase (HO)-1, Alpha mangostin powdercan produce anti-apoptotic effects and protect neurons from the threat of apoptosis.

Parkinson's disease

Antioxidant: In a variety of PD models, alpha mangostin powder exhibits significant antioxidant effects and can reduce the damage of oxidative stress to dopaminergic neurons.

Anti-inflammatory: By inhibiting the activation of microglia and the production of inflammatory factors, alpha mangostin can reduce the inflammatory response of the nervous system.

Anti-neuronal apoptosis: By regulating apoptosis-related signaling pathways such as p53-Bcl-2, alpha mangostin can reduce the apoptosis of neurons in PD models.

Anti-inflammatory effect of alpha mangostin powder

Alpha mangostin powder exhibits significant anti-inflammatory effects, which are achieved through multiple pathways and mechanisms.

Inhibit inflammatory response

Alpha mangostin can significantly reduce the secretion of various inflammatory mediators, such as prostaglandin E2 (PGE2), interleukin-1β (IL-1β), etc. These inflammatory mediators play a key role in the inflammatory response, and their reduction can help relieve inflammatory symptoms.

Alpha mangostin regulates inflammatory responses by inhibiting the Toll-like receptor 4 (TLR4)/nuclear factor-kB (NF-kB) signaling pathway and the MAPK (mitogen-activated protein kinase) inflammation-related signaling pathway. These signaling pathways play an important role in the initiation and maintenance of inflammatory responses, and their inhibition helps reduce inflammatory responses.

Antioxidative stress

Up-regulation and activation of antioxidant enzymes: Alpha mangostin can up-regulate the gene expression and secretion of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), while activating the Nrf2-ARE signaling pathway and up-regulating anti-oxidant enzymes. Expression of oxidases HO-1 and NQO1. These antioxidant enzymes play an important role in scavenging free radicals and reducing oxidative stress.

Alpha mangostin can inhibit the production of reactive oxygen species (ROS), thereby reducing the damage to cells caused by oxidative stress.

Antibacterial

Alpha mangostin has inhibitory effects on a variety of pathogenic bacteria, including Staphylococcus aureus. It inhibits the growth and reproduction of pathogenic bacteria and reduces the invasion and infection of the body by pathogenic bacteria, thereby indirectly reducing the inflammatory response.

What are the application fields of alpha mangostin powder?

Medical field

Rheumatoid arthritis treatment: Alpha mangostin powder and its self-microemulsification preparation technology are used in the treatment of rheumatoid arthritis.

Alzheimer's disease treatment: Alpha-mangostin and its derivatives have been studied chemically and biologically in the treatment of Alzheimer's disease, showing the effects of inhibiting Aβ aggregation and immunosuppression.

Anti-leukemia and sepsis: Alpha-mangostin has a certain therapeutic effect on blood system diseases such as leukemia and sepsis.

Health care products field

Alpha-mangostin is widely used in the field of health care products, including but not limited to the treatment of digestive system diseases, blood system diseases, nervous system diseases, etc.

Treatment of diarrhea and anti-inflammatory effects: Alpha-mangostin is believed to have astringent and antidiarrheal effects and can be used to treat diarrhea. At the same time, it also has anti-inflammatory effects, which can reduce inflammatory reactions and relieve symptoms such as pain and swelling.

Anti-ulcer effect: This substance can promote the repair and regeneration of gastric mucosa, and help relieve the symptoms of digestive system diseases such as gastric ulcers.

Improved neuroprotective activity: Through structural optimization, Alpha-mangostin can reduce toxicity, enhance neuroprotective activity and the ability to penetrate the blood-brain barrier, and improve its drugability.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Alpha Mangostin Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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Why choose us?

We have a professional product development team and perfect customer service. We have our own factory, use advanced production equipment and production technology, professional and experienced technicians to provide you with high-quality and Alpha Mangostin Powder.

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