Aloe Emodin Powder

What is aloe-emodin?

Aloe-emodin powder is the antibacterial active ingredient of rhubarb and can be extracted from aloe vera. is a hydroxyanthraquinone, an active ingredient in aloe vera leaves and rhubarb roots/rhizomes, with specific in vitro and in vivo antineurectodermal activity. Anthraquinones belong to a class of promising tricyclic organic natural compounds. Anthraquinone derivatives possess rich structural diversity and exhibit pleiotropic effects, among which modulation of autophagy appears promising in the context of overcoming therapeutic resistance. One of the most promising derivatives in this regard is aloe-emodin.

It has antibacterial activity, immunosuppressive and purgative effects, and is now widely used as a raw material for pharmaceuticals and cosmetics.

It is an anthraquinone compound with the chemical formula C15H10O5. It is mainly derived from the dried roots and rhizomes of the Polygonaceae plants Rheum palmatumL, Rheum tanguticum Maxim.ex Balf or Rheum officinale Baill.

It is the active antibacterial component of rhubarb. Bacteria that are sensitive to it include Staphylococcus, Streptococcus and diphtheria, subtilis, anthrax, paratyphoid and dysentery. Among them, Staphylococcus and Streptococcus are the most sensitive.

What are the benefits?

Antibacterial

At a concentration of 1.5 to 25 mg/ml, aloe-emodin powder has inhibitory effects on Staphylococcus aureus, Streptococcus aureus, Diphtheria bacillus, Bacillus subtilis, Anthrax, Paratyphoid bacillus, Shigella dysenteriae, etc. Among them, Staphylococcus and Streptococcus are the most sensitive and inhibit The effective concentration of bacteria is 15-25ug/ml. The in vitro inhibitory concentrations for Staphylococcus aureus 209P, Escherichia coli, and Shigella flexneri are 7.5 mg/L and 600 mg/L respectively. Their antibacterial effects are bacteriostatic rather than bactericidal. One of its mechanisms of action is to inhibit mitochondrial respiratory chain electron transport.

It has a strong inhibitory effect on the nucleic acid and protein synthesis of Staphylococcus aureus. It has a strong inhibitory effect on common clinical anaerobic bacteria, among which it can inhibit the growth of 90% to 100% of common Bacillus fragilis strains, and its MIC is slightly higher than that of metronidazole. At a concentration of 8 μg/ml, 76% to 91% of anaerobic bacteria can be inhibited.

Immunosuppressive effects

It can inhibit the production of biological antibodies, inhibit the ability of carbon particles to clear away, reduce the weight of immune organs, reduce the number of white blood cells, and reduce the function of peritoneal macrophages. In vitro, it has a significant inhibitory effect on [3H]-TDR and [3H]Urd infiltration into lymphocytes at a concentration of 100 μg/ml.

Purgative effect

It has strong purgative activity, and intestinal bacteria metabolize aloe-emodin, rhein, and rhein-anthrone, and the latter has a strong purgative effect. Clinically used as a laxative, it has the effects of increasing appetite and relieving large intestine. According to foreign medical reports, aloe glycoside is hydrolyzed into aloe-emodin under the action of parasitic bacteria in the human body. This aloe-emodin stimulates the peristalsis of the intestinal wall. At the same time, due to the change in osmotic pressure, it is conducive to the elimination of waste in the intestine, thereby achieving irritation. Laxative, this stimulating purgative effect has special effects on constipation and hemorrhoids. Especially for middle-aged and elderly constipation, the therapeutic effect is more obvious.

Suppress immune hyperactivity

Abnormal immunity can cause damage to the body. For example, many autoimmune diseases are caused by abnormal expression of autoimmunity and attack normal tissues of the body, causing damage to the body. Aloe-emodin can inhibit the production of antibodies, thereby suppressing immunity. Hyperactive (anti-allergic).

Lipid-lowering and weight-loss effects

It can inhibit cholesterol absorption, and it can effectively promote intestinal peristalsis, so it has a certain effect in lowering fat and losing weight.

Other functions

It has the effect of making hair soft and shiny, relaxing and refreshing, and eliminating dandruff.

This product showed genotoxic effects in the mutagenicity assay of hamster fibroblasts.

Protects teak wood from termites.

Application direction

Pharmacological effects: It has antibacterial activity, immunosuppressive effect and purgative effect. It is now widely used as raw material for medicines and cosmetics.

Aloe emodin Supplier

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