Alginate Oligosaccharide

What is algin oligosaccharide?

Algin is a linear long-chain molecule irregularly linked by 1,4-mannuronic acid (M) and 1,4-guluronic acid (G). It is a functional oligosaccharide obtained through a certain cleavage reaction. It is algin oligosaccharide. It is soluble in water and has strong stability.

An Alginate Oligosaccharide derived from brown algae. Oligosaccharides are also called oligosaccharides (English reference: oligosaccharide; oligosaccharides; oligose). The oligosaccharides obtained from brown algae can be roughly divided into β-D-polymannuronic acid (M) and α-L-polygulose. Linear oligomers composed of alkylic acid (G) include polymannuronic acid (PM), polyguluronic acid (PG) and hybrid fucoidan oligosaccharide (PMG).

By using different degradation methods (acid degradation method, enzyme degradation method, oxidative degradation method) to degrade algin, a series of algin oligosaccharides with a degree of polymerization below 20 can be obtained. It is a linear low polymer composed of β-D-polymannuronic acid (M) and α-L-polyguluronic acid (G), including polymannuronic acid (PM) and polygulurose. There are three types of products: alkylic acid (PG) and hybrid fucoidan oligosaccharide (PMG).

characteristic

Alginate Oligosaccharide is a light yellow-brown powder, soluble in water and has strong stability. Algin oligosaccharides have multiple biological functions and are widely used in medicine, food, daily chemicals, feed and agriculture.

What are the benefits?

1. Lower blood sugar

An appropriate dose of algin oligosaccharide can better prevent the formation of hypercholesterolemia, lower lipids, and maintain normal cardiovascular function.

Anti-free radical oxidation alginate oligosaccharide not only has the effect of scavenging reactive oxygen species, but also can significantly reduce the content of lipid peroxides, increase the activities of peroxidase and superoxide dismutase, and has the ability to scavenge excessive free radicals and Anti-lipid peroxidation effect.

2. Anti-inflammation

It is rich in sources and is theoretically a good anti-inflammatory substitute for sLex, sLea and heparin oligosaccharides, and has good potential medicinal value.

3. Immunomodulatory activity

Stimulates the differentiation, maturation and reproduction of various immune active cells (such as macrophages, T lymphocytes, B lymphocytes, etc.), restores and strengthens the body's immune system, and can exert a variety of physiological activities through immune regulation.

4. Growth regulation effect

AOS is also an important signaling molecule in plants, which can promote plant growth and improve plant resistance to pests and diseases.

5. Hygroscopic and moisturizing properties

The hygroscopic and moisturizing properties of alginic oligosaccharides with degrees of polymerization (DP) of 3, 4 and 6 were measured. The moisturizing properties of DP3 alginic oligosaccharides are particularly outstanding and are much better than glycerol, PEG600 and sodium alginate. At the same time In the case of relatively high relative humidity environment, it shows hygroscopic properties comparable to glycerol.

6. Has antioxidant activity

AOS can effectively reduce hydrogen peroxide-induced HUVEC cell damage, enhance cellular antioxidant enzyme activity, and improve damage caused by oxidative stress.

7. Anti-inflammatory activity

AOS Powder can repair overactivation, restore cells to normal form, and at the same time downregulate the expression of inflammatory cytokines in TNF-α-treated IPEC-J2 cells. In addition to improving skin inflammation, AOS can also repair small intestinal mucositis caused by the chemotherapy drug busulfan and restore damaged small intestinal function. Gastrointestinal mucositis is a common side effect in chemotherapy patients.

8. Inhibit pigmentation

AOS mainly improves pigmentation by inhibiting tyrosinase. The tyrosinase (monophenolase and diphenolase activities) of melanocytes in the basal layer of the human epidermis can convert tyrosine into melanin, and the melanin content is negatively correlated with skin whiteness;

Excessive accumulation of melanin in the skin will not only cause freckles, yellow spots and other spots, affecting the appearance, but may even cause skin lesions such as moles or melanoma. Experiments have shown that AOS can effectively inhibit the activity of monophenolase and bisphenolase. , inhibits the production of melanin, thereby evening and brightening skin tone.

9. Inhibit collagen degradation

When the skin is damaged by UVB irradiation, immunohistochemistry is used to measure the relative content of matrix metalloproteinase-3 (MMP-3) in the skin and enzyme-linked immunosorbent assay is used to measure the content of the characteristic amino acid of collagen - hydroxyproline (HyP).

We found that the AOS group can effectively inhibit the expression of MMP-3 and the degradation of HyP in the skin, thereby effectively increasing the content of skin collagen, inhibiting photoaging damage to the skin, and even regulating the proliferation and migration activity of human keratinocytes HaCaT. Has many effects.

Application areas

Medical field

Fucoidan oligosaccharide has a variety of biological functions. According to its medicinal functions, more and more fucoidan oligosaccharide drugs will be developed.

Such as anti-cardiovascular drugs; sodium salt of propylene glycol sulfate alginate, lipid-lowering and anti-thrombotic drugs; glycolipid antiviral drugs; polyglycolipid anti-urinary stone drugs; ancient glycolipids.

Food field

Used in the food industry as food materials or additives. It has the functions of regulating the intestines, detoxifying, lowering blood sugar and blood lipids, anticoagulation, anti-inflammation, and immune regulation. It can be used as a therapeutic food for patients with diabetes, obesity, colorectal cancer, and habitual constipation. It can also be added to condiments, dairy products, and fruit juices, which not only enriches the taste of the product, but also increases nutrition and has the effect of eliminating heavy metal ions and lowering blood sugar activity. Due to its biological functional diversity, fucoidan oligosaccharides have a wide range of applications in the field of daily chemicals.

Feed field

Fucoidan oligosaccharides overcome the shortcomings of all previous antibiotics, probiotics, enzyme preparations, etc., with small dosage, pure natural, no residue and strong stability, and can improve the animal body's disease resistance, promote animal growth, and increase animal nutrition. It is an excellent feed additive.

Livestock feed additives: pigs, cattle, chickens, etc. Aquaculture feed additives: sea cucumber, abalone, shrimp, etc. In the agricultural field, fucoidan oligosaccharides can stimulate the plant immune system, improve disease resistance, promote cell activation, and stimulate plant growth.

Cosmetics field

It has the functions of moisturizing, antioxidant and inhibiting pigmentation, so it is also widely used in the field of cosmetics.

Alginate Oligosaccharide supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk AOS Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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