Tranexamic Acid Powder

What is Tranexamic Acid Powder?

Tranexamic Acid Powder for skin is a cosmetic raw material for whitening and freckle removal, which is a synthetic amino acid and a protease inhibitor, it can inhibit the activity of tyrosinase enzymes and melanocytes, and prevent pigment aggregation. It can break and clear melanin diffusion deterioration due to UV exposure, and stop the black board thicken, expand and increase, thereby effectively prevent or improve skin pigmentation.

Compared with other whitening ingredients, it has high stability, acid and alkali resistance, uneasily affected by the temperature environment, and does not require carrier protection, not damaged by the transmission system, and non-irritating. So it can be found in a variety of skincare products such as serums, creams, and masks.It is White Crystalline Powder, odorless, slight taste, and soluble in water, almost insoluble in ethanol, acetone, chloroform or ether.

YTBIO Tranexamic Acid Powder Suppliers products are all semi-finished raw materials, and mainly suitable for qualified food factories, health food factories, beverage factories, cosmetics factories, traders, schools, research institutes and other enterprises or related distribution enterprises. Direct consumption is not recommended.

Product Features

1) Its stability is much better than the general traditional whitening ingredients, and it is not easily affected by the temperature environment.

2) It is easily absorbed by the skin, it can not only whiten the skin, but also lighten the spots, meanwhile, it can improve the transparency of the overall skin tone and the dullness of the local skin patches.

3) It can lighten dark spots, yellow freckles, acne marks, etc., which is mainly by inhibiting the activity of tyrosinase and melanocytes to reduce the production of melanin from the basal layer of the epidermis, as well as the redness effect on inflammatory.

4) It is h igh safety, no irritation to the skin for external use, and the highest concentration in cosmetics is 2%~3%.

What does tranexamic acid do?

Whitening and lightening

① Interfering with tyrosinase reaction

Tranexamic acid has a similar chemical structure to tyrosine and can directly compete with tyrosine, interfere with the catalytic effect of tyrosinase on tyrosine metabolism, and reduce melanin production.

② Inhibit the release of prostaglandin E2

Reduces the activity of plasmin, interferes with the interaction between keratinocytes and melanocytes, inhibits the release of prostaglandin E2 (PGE2) from keratinocytes, and reduces the tyrosinase activity of melanocytes induced by ultraviolet rays, thereby reducing melanin production.

③ Inhibit the activation of VEGFRs and the formation of melanin-producing proteins

Tranexamic acid inhibits the activation of vascular endothelial growth factor receptors (VEGFRs) and the expression of melanin-producing proteins in normal human melanocytes, reducing tyrosinase activity and interfering with melanin production.

④ Inhibit melanocyte activation induced by UVB

Inhibits UV-induced melanocyte activation by reducing proinsulin-converting enzyme 2 (PC2) and α-melanocyte-stimulating hormone (α-MSH).

⑤ Activate melanoma cell autophagy

Inhibits melanocyte production by activating the autophagy system.

Fight aging

① Promote the repair of skin barrier and basement membrane zone

Inhibits the activity of serine proteases in the stratum corneum and the expression of antimicrobial peptide LL-37 to repair the barrier; inhibits plasmin, matrix metalloproteinases (MMPs) and trypsin to repair the basement membrane zone.

②Fight against natural aging

Tranexamic acid enhances hyaluronic acid synthesis by increasing the number of epidermal cells, inhibits matrix metalloproteinases (MMPs) by blocking plasmin, thereby reducing the degradation of extracellular matrix (ECM) in the dermis, and can reduce TNF-α in the blood. , IL-6 and reactive oxygen species (ROS) levels to improve the natural aging of the skin.

③ Anti-photoaging

Tranexamic acid can improve UVB-induced photoaging by increasing mitochondrial biogenesis, and can also improve UVA-induced photoaging by increasing the expression of estrogen receptor-β on the surface of mast cells and regulating hypothalamic-pituitary hormones.

Fight inflammation

① Prevent the formation of red blood cells

Tranexamic acid inhibits the overexpression and activation of VEGF growth factor receptors in vascular endothelium, prevents skin angiogenesis, and improves erythema and postoperative bruising.

② Tranexamic acid can inhibit CD4+ T cell infiltration and T cell polarization

Inhibits CD4+ T cell infiltration and T cell polarization induced by human antimicrobial peptide LL37 and exerts anti-inflammatory effects.

③ Tranexamic acid can inhibit pro-inflammatory factors and chemokines

Reduce the expression of pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor α) and chemokines (CCL10) to exert anti-inflammatory effects.

④ Tranexamic acid can inhibit the release of leukotrienes and platelet active factors

Tranexamic acid reduces the release of bradykinin by blocking plasmin. It can also inhibit the release of leukotrienes and platelet active factors by reducing the number and activity of mast cells, thus exerting an anti-inflammatory effect.

Why Can Tranexamic Acid Be Used To Whiten Spots?

At present, the main principles of whitening and lightening1. Inhibit the activity of tyrosinase, thereby reducing the formation of melanin; 2. Promote the metabolism of the epidermis; 3. Inhibit the potential inflammation of the skin.

Tranexamic acid just meets the first and third points. It can not only competitively block the activity of tyrosinase, prevent the synthesis of melanin, but also inhibit the activity of plasmin, improve skin inflammation and vasodilation. You may ask that there are so many whitening products, why is it called a "magic medicine" for whitening? This starts with the history of the discovery of "tranexamic acid": tranexamic acid, also known as tranexamic acid, is a synthetic lysine derivative that belongs to an antifibrinolytic agent. In 1962, it was discovered by the Japanese female doctor Utako Okamoto that the initial application was not for whitening, but for blood coagulation drugs for postpartum hemostasis.

With the widespread use of tranexamic acid, people began to discover that it also has an interesting "side effect", which is whitening and freckle removal. The whitening effect of tranexamic acid is very obvious, and its effect of removing dark spots is about 50 times higher than that of vitamin C, and nearly 10 times that of fruit acid. This made Tranexamic acid even more famous.

Whitening Effect  PK: Tranexamic Acid Vs Vitamin C, Niacinamide

Tranexamic acid has a different whitening mechanism from vitamin C and niacinamide. Niacinamide itself has no effect on the tyrosinase that produces melanin, but affects the transport of melanin. Vitamin C can directly interfere with the production of melanin, reversing one step (dopa to dopaquinone). Tranexamic acid interferes with the production of melanin at the front end, and prevents the transport and diffusion of melanin that has already been generated at the back end. Tranexamic acid is easily absorbed through the skin, has good stability, and is not easily affected by temperature and environment. It doesn't oxidize like vitamin C, doesn't cause flushing like niacinamide, and doesn't leave permanent blemishes like hydroquinone.

Because tranexamic acid Powder has good curative effect and biological safety, it is the first choice product for the treatment of chloasma at present.

Test report on Tranexamic Acid

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