Tetrahydrocurcuminoids

What is tetrahydrocurcumin?

Tetrahydrocurcuminoids (THC), as the active and main metabolite of curcumin produced in the body, is hydrogenated from curcumin isolated from the rhizome of the ginger plant Curcuma longa. Tetrahydrocurcumin is the main whitening active ingredient in natural Turmeric root extract powder. It not only has the strongest tyrosinase inhibitory activity, but also has excellent chemical stability and looks like an odorless white powder, thus overcoming the problem of Ordinary turmeric extract is chemically unstable and easily stains the skin. Ordinary turmeric extract is yellow, has poor chemical stability, and is photosensitive. Under light, it easily reacts chemically with the skin and stains the skin.

What are the benefits?

Protect against UV rays

It can inhibit sunburn caused by UVB and prevent inflammatory reactions caused by ultraviolet radiation.

Free radical scavenging

Free radicals on the skin surface are generated due to ultraviolet rays, chemicals or other stress factors that catalyze skin aging.

The molecular structure of tetrahydrocurcumin contains both phenolic hydroxyl and β-diketone structures and is a natural antioxidant. It can not only remove the generated free radicals, but also inhibit the further generation of free radicals, thereby breaking the chain reaction of free radicals and blocking their damage to the skin and body.

Inhibit tyrosinase

It can effectively inhibit tyrosinase and slow down the production of melanin, and is more effective than whitening agents such as kojic acid, arbutin, and vitamin C. At the same time, the powerful antioxidant activity of tetrahydrocurcumin can also delay the production of melanin, thereby brightening the skin color and achieving whitening effect.

Block inflammation

Tetrahydrocurcuminoids has broad-spectrum anti-inflammatory and antibacterial effects, can repair skin inflammation and skin damage caused by UVB, and can more effectively relieve pain and swelling, and has a significant effect on treating mild burns, skin inflammation and acne scars.

1. Tetrahydrocurcumin can inhibit tyrosinase activity:

Tetrahydrocurcuminoids 95% can reduce the intracellular tyrosinase activity of B16F10 cells in the dose group of 100 and 200 μmol·L -1. When the cells are given corresponding concentrations of tetrahydrocurcumin (100 and 200 μmol·L -1), the intracellular tyrosinase activity decreases. The amino acid enzyme activities dropped to 84. 51% and 83. 38% respectively, and the difference was significantly reduced compared with the blank control group.

2. Prevent excessive pigmentation deposition

It can inhibit the proliferation and migration of B16F10 (mouse melanoma cells) cells, reduce the melanin content in B16F10 cells, and inhibit melanin production. When cells were given corresponding concentrations of THC (25, 50, 100, 200 μmol·L -1), the melanin content dropped from 100% to 74. 34%, 80. 14%, 34. 37%, and 21. 40% respectively. , the difference is statistically significant compared with the blank control group (P ＜ 0. 05 or P ＜ 0. 01)

3. Antioxidant

1) Scavenge DPPH free radicals

Dilute the tetrahydrocurcumin solution 10, 50, 80, 100, 200, 400, 800, 1600 times in sequence, so that the sample solution and 0.1mmol/L DPPH solution are fully mixed in a ratio of 1:5, and react at room temperature. After 30 minutes, the absorbance value was measured at 517nm. The result is shown in the figure:

It can be seen that tetrahydrocurcumin has a certain ability to scavenge DPPH free radicals and exhibits antioxidant ability.

2) Total antioxidant capacity:

The reducing ability of tetrahydrocurcumin to Fe3+ increases with the increase of concentration. When the concentration reaches 10 μmol/L, the reducing ability of tetrahydrocurcumin to Fe3+ is greater than that of vitamin C at the same concentration, and the difference is statistically significant (P ＜ 0. 05).

4. Inhibit skin inflammation

Experimental research shows that after 14 days of continuous observation of wound healing in mice, using THC-SLNs gel, THC and positive control wounds healed faster and with better effects. The descending order is: THC-SLNs gel>THC>Positive Contrast.

The following images are representative images of the excisional wound mouse model and histopathological observations, A1 and A6 show normal skin, A2 and A7 show THC SLN gel, A3 and A8 show positive control, A4 and A9 show THC gel, A5 and A10 show blank solid lipid nanoparticles (SLN), respectively.

Tetrahydrocurcumin liposomes

Inhibit tyrosinase activity + antioxidant + anti-inflammatory repair + protect against ultraviolet rays + reduce melanin precursor polymerization

The new nano-liposome encapsulation technology is used to enclose it in the liposome bilayer, which perfectly solves the application problems caused by its difficulty in dissolving and easily crystallizing, and improves its bioavailability.

Advantages of tetrahydrocurcumin liposomes

Pure plant source, suitable for natural claims

The selected tetrahydrocurcumin is a highly effective whitening and brightening active substance derived from pure natural plants, which is suitable for natural claims.

Liposome bilayer wrapping, not easy to crystallize

Tetrahydrocurcumin liposomes encapsulate tetrahydrocurcumin in the liposome bilayer, which solves the application problems caused by its difficulty in dissolving and easily crystallizing. It has better water solubility and is easy to use.

Liposome encapsulation, with long-lasting sustained release effect

Tetrahydrocurcumin liposomes are liposome-encapsulated, passively targeted preparations that have long-acting sustained release effects, promote penetration, and have more prominent effects, greatly improving its bioavailability.

Contains phospholipids for a unique skin feel

Contains phospholipids, giving it a soft, non-sticky and elegant skin feel.

Tetrahydrocurcumin, as a naturally derived cosmetic whitening raw material, is mostly used in mid-to-high-end whitening cosmetics. Liposomal tetrahydrocurcumin liposomes are among the best whitening ingredients.

Tetrahydrocurcuminoids supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk tetrahydrocurcuminoids 95% powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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