Retinol Powder Bulk

 What is retinol?

Retinol, one of the forms of vitamin A, is a fat-soluble vitamin. It exists in animal food in the form of free aldehyde or ester, and is rich in fat, protein, milk, and liver.
It is necessary to maintain human growth, development, reproduction, and cell membrane stability, and plays an important role in the visual process. It is consumed in the body due to continuous metabolism and needs to be supplemented in time through oxidized vitamin A. It is related to the normal structure and function of cells. When it is deficient, it will cause dryness, inflammation, and even blindness of the conjunctiva and cornea. It will also cause damage to the respiratory epithelium, making it easy to get respiratory infections, hair loss, and infant developmental delay.
Vitamin A oil, as a nutritional supplement, is a fatty oil or its concentrate obtained from the liver and pyloric sac of aquatic animals. Crush fresh fish liver and pyloric sac, and add 1-2% sodium hydroxide solution to pH 8-9. It can be used in sausages, margarine, bread, dairy products, juice powder, peanuts, etc.

Preparation method

It can be obtained by molecular distillation and chromatography refining of cod liver oil, but the method of obtaining pure products is chemical synthesis. The Iserl route (i.e., tetradecaldehyde route) is usually used, that is, p-ionone is first condensed with ethyl monochloroacetate in a sodium methoxide medium, hydrolyzed in sodium hydroxide and methanol, and decarboxylated to obtain tetradecaldehyde. In addition, sodium acetylene is condensed with methyl vinyl ketone below -40°C to produce 3-methylpentyne ene alcohol ; then reacted with ethyl magnesium bromide to produce dibromomagnesium compound; then condensed with tetradecaldehyde and hydrolyzed to obtain hydroxydehydrovitamin A; then catalytically hydrogenated to obtain hydroxyvitamin A, reacted with acetyl chloride in pyridine to obtain hydroxyvitamin acetate, and then brominated and debrominated under alkaline (soda ash) conditions to obtain vitamin acetate.

Effects on the skin:
 

1.Promote cell renewal: It can accelerate the renewal of epidermal cells, help old keratin cells fall off, stimulate the production of new cells, and make the skin smoother and more delicate. This accelerated cell renewal helps reduce wrinkles and fine lines and improve skin texture.
2.Promote collagen production: It can stimulate fibroblasts in the dermis to increase collagen production. Collagen is a key structure to keep the skin firm and elastic, so retinol can help reduce skin sagging and wrinkles caused by aging.
3.Inhibit melanin production: It can help inhibit the excessive production of melanin by regulating the activity of melanocytes, thereby effectively fading spots and sun spots and even out skin tone.
4.Anti-acne effect: It can regulate the secretion of sebaceous glands, reduce excessive oil secretion, prevent pores from clogging, and help prevent acne. At the same time, its cell renewal effect can make existing acne and acne marks heal faster.

Other effects

1.Prevent night blindness: The raw material for synthesizing rhodopsin, a photosensitive substance that exists in the retina and helps protect the cornea and the surface of the eye. And in the form of beta-carotene, it can slow down age-related vision problems. If it is lacking, not enough rhodopsin can be synthesized, which will lead to the appearance of night blindness.
2.Promote growth and development: It can promote the absorption and utilization of calcium in bones, which helps the normal growth and development of bones. It also maintains bone health by regulating the differentiation function of osteoblasts and osteoclasts in the human body. It also affects the production of osteoblasts and osteoclasts, and people with lower concentrations are more likely to fracture.
3.Maintain immune function: It is essential to maintain the normal function of the immune system by regulating target genes through nuclear receptors and promoting immune cells to produce antibodies. It has anti-inflammatory properties, which can optimize the body's immunity and reduce sensitivity to diseases. And the reduction of blood content may put people at risk of disease and impair the body's ability to recover.
4.Effect on teeth:: It can also maintain the health of tooth enamel, promote the growth and development of teeth, prevent tooth decay, and help the renewal of oral mucosa and prevent oral ulcers.

Pathways and mechanisms of action for producing immune effects

By mediating or producing lymphokines through B lymphocytes, it increases immunoglobulin synthesis; together with retinoic acid, it can effectively stimulate polymorphonuclear neutrophils (PMN) to produce a large amount of superoxide, thereby enhancing bactericidal ability. It participates in the process of transporting monosaccharides to receptor proteins in the form of retinyl phosphate, and then synthesizing specific glycoproteins. Since glycoproteins are important components of the cell membrane surface, they play an important role in cell information transmission and adhesion. Therefore, changes in membrane-related protein glycosylation will inevitably affect the recognition mechanism of the cell surface, thereby affecting the proliferation and transport of lymphocytes and the phagocytosis of PMN and macrophages.
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