Potassium methoxysalicylate

What is potassium methoxysalicylate?

Potassium methoxysalicylate is a new type of medicinal whitening ingredient with a structure similar to salicylic acid. In cosmetics and skin care products, it can inhibit the production of melanin and prevent spots and freckles caused by sun exposure. In addition, it can also adjust the condition of the keratinization process, improve skin texture and protect the skin barrier. It can penetrate into the deep pores of the skin, remove some dark pigment particles in the skin, and promote skin metabolism. At the same time, it can also stimulate the blood circulation of the skin, promote the transfer of a large number of nutrients, and thus moisturize the skin.
The main function is to make the skin that is exposed to ultraviolet rays, resulting in disordered and overlapping stratum corneum, and produce dark spots and freckles caused by chronic abnormal keratinization. On the one hand, it has the effect of improving abnormal keratinization, and can actually block the source of melanin production, inhibit melanin production, and prevent the occurrence of dark spots and freckles. If tranexamic acid focuses on the effect, then the appeal of this product is to enhance the self-healing ability. Because when the skin metabolism process is not smooth, the old dead skin cells of the epidermis cannot be completely shed, which not only makes the skin color darker, but also allows melanin to continue to accumulate in the skin. When the skin is exposed to ultraviolet rays again, it will also activate melanocytes. Whitening products with this product can make the outermost layer of the skin healthy and allow melanin to be discharged smoothly. When used in combination with various types of whitening products, the whitening effect of the original whitening products can be improved. More than 50 times that of penetrants or transdermal agents, showing good development prospects.

Main uses:

Whitening effect: By correcting epidermal atypical hyperplasia, poor keratinization and atrophy, melanin is discharged smoothly to achieve smooth and whitening skin.
Keratin metabolism regulation: Coordinate keratin metabolism, block the source of melanin production, and enhance self-healing ability.

Product features
Whitening and balanced skin color: By improving the keratinization process, promote the discharge of melanin, and prevent freckles and spots.
Prevent pigmentation: It has an excellent defensive effect on pigmentation caused by the human body.

Mechanism of action
Correct epidermal atypical hyperplasia, improve the keratinization process, and promote melanin metabolism.

Inhibit melanin production: The key to studying whitening ingredients is to analyze the actual production of melanin and the inhibition of tyrosinase. This product has the effect of inhibiting melanin production and tyrosinase activity under a certain concentration. The former is concentration-dependent in the range of 310-4 and 10-3 mol/L, and the latter is concentration-dependent in the range of 510-4~310-3 mol/L.
PIH defense effect:
Under certain sunlight conditions, 1% potassium 4-methoxysalicylate (4MSK) products have the effect of reducing PIH, and the more the concentration increases, the more significant the reduction. As a whitening ingredient, its action level is still in line with the requirements. There are three action levels for reducing skin dullness, which is a relatively comprehensive whitening ingredient.

Whitening principle:
1. Inhibit the activity of tyrosinase: It has the effect of inhibiting the activity of tyrosinase. Tyrosinase is a key enzyme involved in the synthesis of tyrosinase, and tyrosine is an important component of melanin synthesis. By inhibiting the activity of tyrosinase, this product can reduce the synthesis of tyrosine, thereby blocking the formation of melanin and achieving a whitening effect.
2. Inhibit the synthesis of melanin: It can inhibit the activity of key enzymes related to melanin synthesis, such as tyrosine phosphatase and dihydroxyphenylpyruvase. These enzymes are indispensable participants in the formation of melanin. By inhibiting their activity, the synthesis of melanin can be reduced, thereby achieving a whitening effect.
3. Antioxidant effect: It has an antioxidant effect, can neutralize free radicals, and reduce the occurrence of oxidation reactions. Free radicals are one of the main causes of skin aging and pigmentation. By inhibiting the generation of free radicals and removing existing free radicals, it can reduce the phenomenon of skin aging and brighten the skin tone.
4. Exfoliation of the stratum corneum: It has a certain exfoliation effect, which can remove the old stratum corneum and promote the generation of new keratinocytes. The stratum corneum is affected by pollution, aging and other factors, which will make the skin dull and not smooth. By removing the old stratum corneum, the skin can be made smoother, delicate, and brighter.
5. Anti-inflammatory effect: It also has a certain anti-inflammatory effect, which can reduce the discomfort of redness and itching of the skin. Inflammatory response accelerates the formation of melanin and the process of skin aging. By inhibiting inflammatory response, the formation of melanin and the degree of skin aging can be reduced.
In short, its whitening principle is to achieve the purpose of whitening skin color through the comprehensive effects of inhibiting tyrosinase activity and melanin synthesis, anti-oxidation, exfoliation of stratum corneum, anti-inflammatory effect and other aspects. It can reduce the formation of melanin, fade spots, brighten skin color, and has the effect of reducing skin aging.

Application in cosmetics:
It has good water solubility, and is in an ionic state in aqueous solution. Acidic buffer can increase its stability. However, potassium methoxysalicylate aqueous solution is in an ionized form, resulting in poor skin permeability, which is not conducive to its due efficacy. Therefore, when designing product formulas, it is necessary to consider enhancing its transdermal absorption concentration. The "Cosmetic Safety Technical Specifications" require that its maximum allowable concentration in cosmetics is 3.0%, and it shall not be used in products for children under three years old.
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