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PDRN Powder
Source: Male Salmon
Appearance：White Powder Or Fibrous Solid
Solubility: Soluble In Water
Sales Group: Not For Individual Vustomers
Shipping speed: 3-5 days
Storage Conditions: Cool And Dry Place
Payment: T/T,VISA,XTransfer,Alipay
Certificates: HACCP, HALAL, KOSHER, ISO9001, ISO22000, FDA
- Fast Delievery
- Quality Assurance
- 24/7 Customer Service
Product Introduction
What is PDRN?
PDRN Powder is the abbreviation of polydeoxyribonucleotide, also known as Sodium DNA. It is a mixture of active polynucleotides with a molecular weight range of 50~1500 kDa. Its sources include human placenta, red algae, ginseng, and sperm cells of salmon or salmon. It is also the core ingredient of the "Salmon Water Light Injection" commonly used in medical beauty. Its unique molecular structure gives it strong biological activity and stability, and it can easily penetrate the skin barrier and reach the bottom of the skin.
Sodium DNA is an optimized DNA fragment. This ingredient has a similarity of up to 98% with the human DNA base sequence, which makes it highly compatible in the human body and can be quickly absorbed by skin cells. Its biological activity can interact with human cells and affect human cells. As an emerging anti-aging ingredient, it has been well known for its unique skin care concept and superb anti-aging effect since its launch. It is widely used in cosmetics and personal care products and has the function of promoting skin repair and regeneration.
Test Report
| ITEM | STANDARD | TEST RESULT |
| Assay | ≥90% | 98.7% |
| Molecular Weight | <1000KD | 725KD |
| Physical & Chemical | ||
| Appearance |
White powder or off-white powder or light yellow powder |
Complies |
| Identification | UV:Ratio of absorbance at 260 and 280nm1.8-2.0 | 1.8 |
| PH | 5.0-9.0 | 7.5 |
| Loss on Drying | ≤20% | 8.1% |
| Solubility | Slightly soluble in water | Complies |
| Heavy Metal | ||
| As | ≤1.0ppm | 0.15ppm |
| Pb | ≤1.0ppm | 0.27ppm |
| Cd | ≤1.0ppm | 0.11ppm |
| Hg | ≤0.5ppm | 0.01ppm |
| Microbiological Test | ||
| Total Plate Count | ≤1,00cfu/g | <100cfu/g |
| Mold and Yeast | ≤100cfu/g | <40cfu/g |
| Thermotolerant Coliform Bacteria | Negative | Negative |
| Staphylococcus Aureus | Negative | Negative |
| Pseudomonas Aeruginosa | Negative | Negative |
| Conclusion Conform with specification | ||
| Storage Store in cool and dry places. Keep away from strong light and heat | ||
| Packing By 1kgs/Drum, inner by double plastic bag | ||
| Shelf Life 24 months under the above condition,and in it’s original package | ||
Features
Compliance: Safety assessment and toxicity testing projects have been completed.
Safety: The raw material product is a non-toxic, non-irritating and safe substance.
Effectiveness: By cutting DNA into certain active fragments, it repairs the skin base internally and the barrier externally.
Stability: The aqueous solution of the raw material product has good light stability, thermal stability, pH stability and ion stability.
Mechanism of action
Participate in the "salvage pathway" to provide raw materials for cell DNA synthesis
After being enzymatically hydrolyzed, it can provide purine and pyrimidine to promote cell growth. The salvage pathway can recycle the bases and nucleosides produced by the decomposition of DNA and RNA, and the recovered bases can be converted into nucleotides and re-incorporated into DNA. The nucleotides and nucleosides produced by Sodium DNA (PDRN) can quickly contribute to DNA generation and quickly provide raw materials for tissue regeneration and damage repair.
As an agonist of adenosine receptor 2 (A2A), it participates in the activation or inhibition of multiple pathways, regulates downstream products and exerts a variety of pharmacological effects
1. By activating adenosine A2A receptors, inhibiting the activation of the nuclear factor-κB signaling pathway, and reducing the expression of pro-inflammatory markers such as interleukin IL-6, it exerts an anti-inflammatory effect.
2. By stimulating A2A receptors, it induces intracellular cAMP activation, promotes protein kinase A (PKA) and cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation, upregulates anti-apoptosis related proteins, inhibits the expression of apoptosis protein activating factor-1 (Apaf-1) and cysteine-containing aspartate protein hydrolase (Caspase)-3 and Caspase-9, thereby exerting an anti-apoptotic effect.
3. By activating A2A receptors, it promotes wound healing and tissue repair, thereby enhancing angiogenesis and improving microcirculation.
4. By stimulating A2A receptors, it can inhibit ERK phosphorylation to activate the MAPK pathway, inhibit the expression of MMP and inflammatory factors, and play a positive role in skin regeneration.
In the diabetic mouse model, wound healing was significantly promoted by increasing the expression of VEGF.
Proliferation and migration of human skin fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) after treatment with different concentrations of PDRN.
Treatment-induced cytotoxicity and proliferation
Treatment of human skin cells increases cell migration
It can promote collagen synthesis, inhibit the production of metalloproteinases and elastase, play a role in remodeling the extracellular matrix and fighting skin aging.
Benefits for Skin
Delay skin aging
Repair DNA damage, speed up the repair of damaged cells, promote cell metabolism, make the skin younger and more energetic, inhibit the decomposition of collagen, and thus delay skin aging.
Antioxidant
It can effectively remove free radicals, reduce the damage of skin cells by free radicals, and improve skin condition.
Anti-inflammatory
It can regulate the expression of inflammatory factors, inhibit the excessive occurrence of inflammatory reactions, promote the production of anti-inflammatory factors, and inhibit the release of pro-inflammatory factors.
Repair skin barrier
It has the ability to promote tissue repair, accelerate the regeneration and healing of damaged skin tissue, increase skin thickness and elasticity, and improve skin sensitivity.
Inhibit melanin formation
It can inhibit the activity of tyrosinase and reduce the production of melanin, thus having a certain whitening effect. This has a certain effect on the treatment of chloasma and photoaging spots.
Promote skin collagen regeneration
It can secrete a small amount of collagen and non-collagen substances. Continuously stimulate fibroblasts to secrete extracellular matrix, increase collagen, elastic fibers, and reticular fiber regeneration.
Applications
Biocosmetics and Cosmetics
It is widely used in the biocosmetics and cosmetics industry, mainly in skin care products and cosmetic injection products. It has the effects of promoting skin repair, enhancing skin barrier function, and promoting collagen production, which can help slow down the skin aging process and improve skin quality.
Medical Beauty
In the field of medical beauty, it is used for various anti-aging treatments, such as anti-aging and other forms of skin regeneration treatments. It helps improve skin sagging and wrinkles by promoting cell regeneration and repair.
Certificates
YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality PDRN Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.
Packaging and Shipping
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