Palmitoylethanolamide PEA powder

What is palmitoylethanolamide PEA powder?

Palmitoylethanolamide PEA powder is an endogenous fatty acid amide that belongs to the class of nuclear factor agonists. PEA has been shown to bind to nuclear receptors (NRs) and exert a large variety of biological functions related to chronic pain and inflammation. The main target is believed to be peroxisome proliferator-activated receptor alpha (PPAR-α).
It works by altering the expression of certain genes to reduce inflammatory signals, and other possible analgesic mechanisms - the ability to stimulate signals through cannabinoid receptors in the nervous system.
Multiple clinical studies have shown that it has anti-inflammatory, anti-nociceptive, as well as neuroprotective and anticonvulsant properties; it can regulate many physiological processes, including pain perception, convulsions, and neurotoxicity. Clinical studies have shown that supplementing with PEA can relieve chronic pain caused by a variety of reasons without side effects. PEA can relieve pain types including diabetic neuropathy, chemotherapy-induced peripheral neuropathy, sciatica, carpal tunnel syndrome, osteoarthritis, post-herpetic neuralgia, stroke-related neuralgia, multiple sclerosis, dental pain, as well as vaginal pain, low back pain and chronic pelvic pain.

According to the American Cosmetic Association, palmitoylethanolamide has the functions of "surfactant-foam promoter; viscosity increaser-water-based", and the Korean Cosmetic Association also introduces its formulation purpose as a surfactant (foam promoter) and a viscosity increaser (water-based).
It is reported that it can indirectly activate cannabinoids (Cannabinoid, CB) Receptors. Representative cannabinoid receptors are CBR1 and CBR2, of which CBR1 is mostly present in the central nervous system and CBR2 is present in the immune system. Palmitoylethanolamide inhibits inflammation by engaging CBR2 through PPAR-a. When added to deodorants and sweat-inhibiting dosage forms, itching induced by histamine is reduced, and IL-6, an inflammatory indicator, is reduced.

Preparation:

Usually involves esterification reaction. During the preparation process, palmitic acid and ethanol are generated through esterification reaction under the action of a catalyst. During the preparation process, factors such as reaction temperature, catalyst type and dosage, reaction time, etc. have an important influence on the quality and yield of the product. Therefore, optimizing the preparation process is necessary. Technology is the key to improving product quality and reducing costs.

Properties:

It is a white to slightly yellow solid with good solubility and stability. It is solid at room temperature, but soluble in a variety of organic solvents such as ethanol, acetone, etc. at a certain temperature. In addition, it has good thermal stability and chemical stability, which allows it to maintain its structure and properties under high temperature and complex environments.

Efficacy:

1. Anti-aging effect
It is antioxidant and can increase the moisture content of the skin. The antioxidant property helps to reduce the production of free radicals, thereby reducing signs of skin aging such as fine lines and wrinkles. At the same time, it can also increase the synthesis of collagen, promote cell regeneration, and make the skin more Tighten and make it elastic.
2. Moisturizing effect
Its moisturizing ability is one of its major features. It can form a protective film to prevent water loss, thereby keeping the skin moisturized. In addition, it can promote the synthesis of intercellular lipids, enhance the water retention capacity of the stratum corneum, and increase the water content of the skin.
3. Repair effect
It has the effect of repairing the skin. It can promote skin metabolism, accelerate cell renewal, and reduce skin problems caused by external stimuli. In addition, it also has anti-inflammatory effects, which can soothe skin inflammation, reduce redness and itching.
It is widely used in skin care products such as creams, lotions, essences, etc. According to the needs of the skin, you can choose suitable products to enjoy its benefits. When choosing a product, you should pay attention to choosing one with sufficient concentration to ensure its effectiveness.
4. Relieve chronic pain
Clinical studies have shown that supplementing PEA can effectively relieve chronic pain caused by a variety of reasons, and usually without obvious side effects. The types of pain that PEA can relieve include but are not limited to:
Chemotherapy-induced peripheral neuropathy; stroke-related neuralgia; dental pain; vaginal pain. PEA helps alleviate these pain symptoms through its inherent biological mechanism.
5. Anti-inflammatory effect:
By binding to nuclear receptors (such as peroxisome proliferator-activated receptor α, PPARα), it regulates gene expression, thereby reducing the production of inflammatory signals. In addition, it can also further exert its anti-inflammatory effect through cannabinoid receptor stimulation signals.
6. Neuroprotective effect
It has neuroprotective properties and can protect nerve cells from damage. This may be related to its anti-inflammatory and antioxidant effects, making it potentially useful in the treatment of neurodegenerative diseases.
7. Anticonvulsant effect
It can regulate physiological processes such as pain perception, convulsions, and neurotoxicity, thereby exerting its anticonvulsant effect.
In addition to the above effects, it has also been found to be used to prevent respiratory viral infections. It can reduce the toxicity of viruses in organisms by regulating immune responses. However, repeated applications may induce macrophage activation and affect the production of interferon.

Applications:

1. Cosmetics industry: It has good lubricity and emulsification and can be used to make various cosmetics, such as moisturizers, shampoos, etc. In cosmetics, it can enhance the consistency and stability of the product, while improving the moisturizing and nourishing effects of the product.
2. Textile industry: In the textile industry, it can be used as a softener, antistatic agent and lubricant. It can improve the softness and glossiness of the fabric, while reducing the friction coefficient and electrostatic effect of the fabric, making the fabric more comfortable and easy to wear.
3. Ink industry: It has good dispersibility and stability in ink and can be used to make various ink products. It can improve the fluidity and printing performance of the ink, and improve the clarity and color vividness of the printed product.
4. Plastic industry: In the plastic industry, it can be used as a plasticizer, lubricant and dispersant. It can improve the softness and toughness of plastics, while reducing the processing temperature and energy consumption of plastics, and improving production efficiency.
Formulation
Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality palmitoylethanolamide PEA powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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