Oleoylethanolamide Powder

What is Oleoylethanolamide?

Oleoylethanolamide Powder, referred to as OEA, has a chemical formula of C20H39NO2. It is an N-oleoylethanolamide, a member of the endogenous cannabinoid class of substances, composed of lipophilic oleic acid and hydrophilic ethanolamine. It is slightly soluble in water and easily soluble in organic solvents such as ethanol. This compound is widely present in animal and plant tissues such as cocoa powder, soybeans and nuts, but the content in these tissues is low. Only when the external environment changes or food stimulation, the body's cell tissues will produce more of this substance. It is produced when the body is stimulated and has a series of biological activities, including controlling appetite, improving lipid metabolism, and strengthening memory and cognition. OEA is a compound with multiple physiological activities and has good application prospects in dietary supplements, medicine, cosmetics, etc. 

Product Details Table

Features

1. It is considered to be a safe compound, non-toxic and non-irritating.
2. It is soluble in DMSO or ethanol and shows good solubility.
3. It is stable under storage conditions (such as -20°C) and the solution can be stored for a long time.
4. It is composed of ethanolamine and oleic acid combined by amide bonds, and has hydrophilicity and lipophilicity, which makes it play an important role in organisms.
5. It is a non-ionic surfactant with the ability of cleaning, emulsification, foaming, foam stabilization, dispersion, solubilization, antistatic, lubrication, rust prevention and corrosion inhibition, and anti-wear.

What Are The Physiological Functions?

Antioxidant

It has antioxidant effects, can remove free radicals and protect cells from oxidative damage.

Anti-inflammatory

It has anti-inflammatory effects, can reduce inflammatory responses, inhibit the production of inflammatory factors, and reduce the degree of inflammation.

Regulate lipid metabolism

It can improve lipid dysfunction and help reduce total cholesterol and low-density lipoprotein (LDL) concentrations in the blood without reducing high-density cholesterol (HDL) concentrations.

Inhibit lipolysis

OEA can inhibit lipolysis in adipocytes and reduce fat consumption.

Promote adipocyte differentiation

It can promote adipocyte differentiation, increase the number of adipocytes, and improve fat storage capacity.

Neurobehavioral improvement

It can improve neurobehavioral symptoms such as depressive behavior, and has the ability to regulate the activity of converters in the lysosome-to-nuclear signaling pathway associated with longevity regulation.

Activate PPARα oil

It is an endogenous cannabinoid analog that can activate peroxisome proliferator-activated receptor α (PPARα), thereby controlling appetite, improving lipid metabolism, and enhancing memory and cognition.

Regulate appetite

Oleoylethanolamide Powder can regulate the expression of appetite-related genes by activating peroxisome proliferator-activated receptors (PPAR) α and γ, thereby affecting appetite. Studies have found that supplementing with oleoylethanolamide can reduce appetite and help lose weight.

Improve blood lipid metabolism

It can lower blood lipid levels and has a protective effect on cardiovascular disease. Studies have found that oleoylethanolamide can reduce low-density lipoprotein cholesterol (LDL-C) levels and increase high-density lipoprotein cholesterol (HDL-C) levels, thereby improving blood lipid metabolism.

Effects of Oleoylethanolamide (OEA) on Aβ pathology and cognitive function

OEA can promote transcription factor EB lysosomal function in a PPARα-dependent manner, leading to enhanced Aβ uptake and clearance in microglia. Treatment of AD mice with stable analogs of OEA can restore lipid dysregulation, reduce reactive gliosis and Aβ pathology, and improve cognitive impairment.

As a lipid amide, OEA can be hydrolyzed by fatty acid amide hydrolases. The regulatory effect of OEA is attributed to its binding to PPARα, which, after dimerization with retinoid X receptor (RXR), acts as a potent transcription factor to activate downstream targets involved in combined energy homeostasis, lipid metabolism, autophagy, and inflammation.

KDS-5104 acts directly on PPARα and then regulates TFEB and downstream signaling, which in turn feedbacks to continue to enhance PPARα activity.

The PPARα-CD36 pathway regulates Aβ phagocytosis, while the PPAR-TFEB interaction promotes lysosomal degradation of Aβ.

KDS-5104 treatment significantly increased PE, PC, and TG, and DG also tended to increase, improving the dysregulation of lipid metabolism.

The size and number of Aβ plaques in mice in the KDS-5104 group were reduced, the number and area of ​​plaque-associated microglia were reduced, and reactive microglia were also reduced.

In general, supplementation of OEA may be a potential therapeutic strategy for AD, and as an endogenous lipid molecule, it has a relatively high safety.

Applications

Dietary supplements

Oleoylethanolamide Powder is used as a dietary supplement to help inhibit food intake, which may help lose weight.

Daily chemical products

Personal care: As a foam stabilizer, thickener, antistatic agent, etc., it is used in personal care products such as shampoo and shower gel to enhance the product experience.

Household washing: In detergents, the decontamination, emulsification and foam stabilization capabilities of oleoyl monoethanolamide make it an important ingredient to improve cleaning effects.

‌Medicine

It can be used to treat Parkinson's disease and help improve patients' cognitive function and brain health.

Formulation Of Oleoylethanolamide

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Oleoylethanolamide Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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