Oat peptide

What Are Avena Sativa (Oat) Peptide?

Oat peptide is a plant complex extracted from alpine oats and mainly contains oat protein and oat beta-glucan. It can form a protective film on the skin, tighten and soften fine wrinkles, lock in skin moisture, give the skin a smooth, silky touch, and prevent skin aging.

Based on a unique advanced production process, the extracted small molecule active peptides are detected by HPLC and GPC methods. The molecular weight of the product is mainly concentrated between 2000 and 15000 Da, and contains a large number of hydrophilic groups.

It has excellent cosmetic effects and is widely used in skin care products. It has excellent film-forming properties, can form a film at low concentration, embed or isolate small molecular substances, penetrate the skin and dry hair, and form a protective layer on the surface of the skin and hair. It has the function of inhibiting MMP-1 activity and increasing collagen content in the skin. It can effectively block the chain reaction that is extremely harmful to the skin, thereby maintaining the integrity of the skin structure, inhibiting skin thinning, and enhancing skin elasticity. The small molecule bioactive peptide in Avena Sativa Peptide is very similar to cell growth factor (EGF), which can accelerate cell proliferation, promote skin metabolism, activate the skin, reduce skin roughness, and make the skin radiant and charming.

The extraction process is very mature and has been used in many beauty products. It is refined from high-quality oat protein through the enzymatic hydrolysis process of compound enzyme preparations. Its structure is similar to natural moisturizing factor (NMF). It has excellent moisturizing properties and can quickly Penetrates the skin to provide deep moisturizing properties.

What are the benefits?

Promote fibroblast proliferation

Cytokines (CK) are a general term for biologically active low-molecular-weight proteins or polypeptides synthesized and secreted by cells (immune cells and non-immune cells). When the proteins in the skin are destroyed, they become many small fragments called "cytokines", which transmit signals to the skin and promote the production of new cells in the skin.

Containing small molecule peptides, which are very similar to cytokines, the skin misjudges Avena Sativa Peptide as cytokines, thereby spontaneously accelerating cell proliferation, promoting skin metabolism, and revitalizing the skin.

Promote fibroblast proliferation

Normal human skin fibroblasts were inoculated into a 96-well plate. In DMEM medium containing 5% wild calf serum, the substance to be detected was made into an aqueous solution and added four times to cause the cells to grow exponentially. . Basic fibroblast growth factors served as positive controls. Cell culture was terminated after 96 h.

Among the test results of several substances, oat active peptide showed the strongest stimulating activity, which was significantly higher than the other three skin substances. Commercially synthesized peptides showed no proliferative effect on human skin fibroblasts. Rice peptides and soybean peptides had smaller regulatory effects in the experiment.

Reduce skin roughness

In the experiment, volunteers were asked to apply cosmetics containing 10% oat peptide on the inside of their forearms once a day in the morning and evening. After 4 weeks of continuous use, it can be clearly seen that the skin texture has become delicate and smooth.

Anti-wrinkle function

20 volunteers were divided into two groups and a sensory comparison experiment was conducted. In the test, one group of volunteers applied cosmetics with 10% Avena Sativa (Oat) Peptide on their eyes, while the other group applied cosmetics with the same amount of placebo for experimental comparison.

The experimental results showed that 80.5% of the people in the group using 10% content had significant anti-wrinkle effects, and 90% of the volunteers reported significant effects within 5 minutes of use. Only 23.5% of the people in the placebo group had wrinkle reduction effects.

Moisturizing function

Comparison of moisturizing properties between oat peptides and hyaluronic acid

The experiment used 5% Avena Sativa (Oat) Peptide and 0.1% hyaluronic acid to compare the moisturizing properties.

It can be seen that the moisturizing effect of Avena Sativa (Oat) Peptide at 5% concentration is better than that of hyaluronic acid. At the initial time, it is slightly lower than hyaluronic acid, but after about 45 minutes, its moisturizing effect begins to be better than that of the same concentration. of hyaluronic acid. From 1 hour to 4 hours after application, the moisturizing effect of Avena Sativa (Oat) Peptide is stable. Although the moisturizing effect of hyaluronic acid is also ideal, its moisturizing effect decreases significantly as time goes on. Compared with Avena Sativa (Oat) Peptide's moisturizing effect is more durable, efficient and stable.

It can also inhibit protease activity and have antioxidant effects; it can also help penetration, helping the skin to better absorb other nutrients; at the same time, it can provide nutrition to the skin, condition the skin, effectively moisturize the skin, and reduce skin roughness. It can be absorbed directly through the skin through the carrier. It has the characteristics of fast speed and low energy consumption during the absorption process. After being absorbed, it can eliminate the absorption in the form of amino acid residues (PAA) in the process of promoting cell proliferation. Amino acids compete with each other to promote rapid protein synthesis.

The small molecule bioactive peptides in Avena Sativa (Oat) Peptide are very similar to cell growth factors, which can accelerate cell proliferation, promote skin metabolism, activate skin, reduce skin roughness, resist free radicals, and make the skin radiant.

It also has the effect of inhibiting MMP-1 activity and increasing the content of collagen in the skin. It can effectively block the chain reaction that is extremely harmful to the skin, thereby maintaining the integrity of the skin structure, maintaining skin elasticity, and inhibiting skin thinning and elasticity decline.

The oat β-glucan in Avena Sativa (Oat) Peptide has excellent anti-aging effects and can smooth fine wrinkles, increase skin elasticity, and improve skin texture. β-glucan has a linear molecular structure and has good anti-aging properties. Transdermal absorption properties promote fibroblasts to synthesize collagen, promote wound healing, and repair damaged skin.

Mechanism of action

It can be absorbed directly through the skin through the carrier. It has the characteristics of fast speed and low energy consumption during the absorption process. After oat peptide is absorbed, it can eliminate the form of amino acid residues (FAA) in the process of promoting cell proliferation. Amino acids compete with each other during absorption, thereby promoting rapid protein synthesis.

More importantly, the protein components extracted from oats are very similar to cell growth factors. The skin often misjudges oat protein as cell growth factors, thereby spontaneously accelerating cell proliferation and promoting the entire metabolism. In addition, the peptide ingredients in the product contain a large number of hydrophilic groups and are highly moisturizing substances, which can promote and ensure the moisturizing effect of the product after it is added to cosmetics.

Antioxidant assay

Test methods

Dilute oat polypeptide with deionized water to obtain solutions of different concentrations, measure its antioxidant properties (including DPPH free radical scavenging rate, hydroxyl free radical scavenging rate, Fe2+ chelating ability), and calculate the scavenging of DPPH free radicals, hydroxyl free radicals and chelating capacity. The IC50 of Fe2+ was compared with the IC50 of a standard antioxidant.

Determination of DPPH free radical scavenging ability:

Figure shows the relationship between Avena Sativa (Oat) Peptide and VC concentration and DPPH free radical scavenging rate. It can be seen from this figure that as the concentration (0-8.40 mg/mL) increases, its DPPH free radical scavenging rate continues to increase. The IC50 of Avena Sativa (Oat) Peptide in removing DPPH free radicals (that is, the concentration of Avena Sativa (Oat) Peptide when the DPPH scavenging rate is 50%) is 2.63 mg/mL.

Determination of hydroxyl radical (•OH) scavenging ability:

Hydroxyl radical (•OH) has a strong ability to obtain electrons, that is, oxidizing ability, and Avena Sativa (Oat) Peptide has electron-donating groups such as sulfhydryl and phenolic hydroxyl groups in its amino acid composition, which can cause oxidation-reduction reactions with hydroxyl radicals. Thereby scavenging light radical free radicals. The relationship between Avena Sativa (Oat) Peptide and VC concentration and hydroxyl radical scavenging rate is shown in the figure.

It can be seen from the figure that as the concentration increases, the hydroxyl radical scavenging rate increases sharply. When the concentration reaches 0.30 mg/mL, the hydroxyl radical scavenging rate reaches 95.6%. Its effect in scavenging hydroxyl free radicals is much better than that of VC. Avena Sativa (Oat) Peptide has an IC50 of 0.15mg/mL for scavenging hydroxyl radicals.

Determination of Fe2+ chelating ability:

Fe2+ can promote lipid peroxidation to form free radicals through Fenton reaction. Therefore, reducing the concentration of Fe2+ during the Fenton reaction can prevent oxidative damage in the human body. This assay studies the ability of oat peptides to chelate Fe2+, using EDTA as a standard for comparison. The results are shown in Figure 3-12. Within the concentration range examined, as the concentration of Avena Sativa (Oat) Peptide increases, its Fe2+ chelation rate continues to increase. Avena Sativa (Oat) Peptide has an IC50 of 0.36 mg/mL for chelating Fe2+.

The measurement results

The IC50 for scavenging DPPH free radicals is 2.63 mg/mL, the IC50 for scavenging hydroxyl free radicals is 0.15 mg/mL, and the IC50 for Fe2+ chelation is 0.36 mg/mL, indicating that Avena Sativa (Oat) Peptide has good antioxidant properties.

Avena Sativa (Oat) Peptide Supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk Avena Sativa (Oat) Peptide and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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