Madecassoside Powder

What Is Madecassoside?

Madecassoside Powder is a naturally occurring active ingredient and one of the earliest major terpenoid compounds found in Centella asiatica extract. It is mainly found in perennial herbs of the Umbelliferae family such as Centella asiatica and has a variety of pharmacological activities and clinical applications. Madecassoside B exists in madecassoside in a free form and is an isomer. Madecassoside B is also known as terminoside. Modern technology purifies them together without separation and collectively refers to madecassoside. Studies have shown that it has a wide range of pharmacological effects. It is used for skin whitening, anti-inflammatory and antioxidant, anti-depression, prevention and treatment of coronary heart disease, myocardial infarction, cerebral thrombosis, memory enhancement, etc.

Product Details Table

Function

Promote collagen synthesis

Helps stimulate the synthesis of type I and type III collagen, thereby promoting skin cell renewal and improving skin elasticity.

Anti-inflammatory

Can reduce the production of inflammatory mediators, improve and repair skin barrier function, prevent and correct skin immune function disorder.

Antioxidant

Can improve the skin's own SOD superoxide dismutase activity, regulate skin immunity, dilute melanin deposition, and have antioxidant ability to inhibit free radicals. Helps to delay the aging process and protect the skin from free radical damage.

Antibacterial

Can dissolve the outer wax film of bacteria, has antibacterial properties, can inhibit the growth of harmful bacteria and mites on the skin surface, and enhance the skin's immune regulation function.

Repair skin damage

It has a significant promoting effect on burn healing, and its mechanism of action is related to inhibiting lipid peroxidation, promoting collagen synthesis and inhibiting apoptosis.

Soothing and repairing skin

Can inhibit neutrophils, calm the skin, and relieve skin sensitivity. It helps to repair damaged skin tissue, especially in repairing skin barriers, allergic skin, chemical burns, etc.

Whitening and spot-lightening

It also performs well in lightening spots. It can help even out skin tone, reduce melanin and spots.

Promote wound healing

It has a "double healing effect", which can not only promote wound healing, but also inhibit the formation of scars. It accelerates wound repair by promoting the growth of fibroblasts and the synthesis of collagen.

Delaying aging

It can help increase the thickness and density of the dermis, improve wrinkles, and thus delay the aging process.

Separation and purification

1. Chromatographic conditions

Preparative HPLC conditions: self-filled Microsorb C18 column (50 mm X200 mm, 5μm); mobile phase: methanol water (volume ratio of 60:40), flow rate 100mL/min; detection wavelength: 220 nm; injection volume: 1.5mL.

Analytical HPLC conditions: Microsorb C18 column (4.6mmX250mm, 5μm) filled by Dalian Jiangshen Company; mobile phase: methanol water (volume ratio of 60:40), flow rate 1mLmin; detection wavelength: 200 nm; injection volume: 10μL.

2. Experimental method

Weigh 6g of crude Centella asiatica glycoside sample and dissolve it in methanol to prepare a solution with a concentration of 40mg/mL, pass through a 0.45μm microporous filter membrane for sample analysis and preparation. Take an appropriate amount of the treated sample solution, dilute it 10 times with methanol and analyze it. Take asiaticoside and madecassoside as reference substances and quantify it by external standard method. The crude asiaticoside sample contains 20% asiaticoside and 45% madecassoside. Prepare and purify it by preparative HPLC system, inject it multiple times, collect the eluent containing asiaticoside and madecassoside, concentrate it under reduced pressure, and dry it in an oven to obtain 0.8g asiaticoside and 2g madecassoside.

Application

Beauty and skin care

Due to its properties of promoting skin repair and anti-inflammatory, it is widely used in skin care products such as creams, essences, and masks to help improve the repair and anti-inflammatory symptoms after skin damage.

Cosmetics

In cosmetics, it is mainly used for anti-inflammatory, scar removal, acne removal, soothing, anti-aging and other products to help improve skin conditions and enhance skin health.

Health products

The application in health products is mainly reflected in improving memory, anti-anxiety, anti-depression, etc., and has the effect of protecting neurons and protecting the liver and detoxifying.

Medicine

It has significant effects in the treatment of skin diseases and trauma, such as for the treatment of trauma, burns, keloids, etc.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Madecassoside Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

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