Idebenone Powder

What is idebenone powder?

Idebenone powder is a highly lipophilic compound that can also be dissolved by heating with an appropriate amount of grape seed oil. It is structurally similar to coenzyme Q10. As a highly effective antioxidant, it has cosmetic effects such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, reducing pigmentation, improving fine lines, wrinkles and age spots. 

Currently, idebenone has been used in cosmetic formulations. However, considering its irritation and poor stability, further research on idebenone microemulsion is needed to make it more effective. Safely used in cosmetics. Idebenone is an organic compound with the molecular formula C19H30O5. It is yellow crystal or crystalline powder and odorless. Extremely difficult to dissolve in water, extremely soluble

It is soluble in chloroform, methanol or absolute ethanol, easily soluble in ethyl acetate, and insoluble in n-hexane. Used in cosmetic formulations to scavenge free radicals and inhibit lipids

It has cosmetic functions such as plasma peroxidation, inhibition of inflammation, inhibition of DNA damage, photoprotection, and reduction of pigmentation.

Principle of action:

Idebenone powder Bulk is an analogue of coenzyme Q10. Coenzyme Q is a fat-soluble quinone compound widely present in organisms and has the ability to promote oxidative phosphorylation reactions.

function to respond and protect the structural integrity of biofilms. Different sources of coenzyme Q have different numbers of isopentenyl units in their side chains. Humans and mammals are

10 units of isopentene, hence the name Coenzyme Q10. Coenzyme Q plays an important role in proton translocation and electron transfer in the respiratory chain in the body. It is a key component of cellular respiration.

And activator of cell metabolism, it is also an important antioxidant and non-specific immune enhancer.

The role of idebenone

1. Excellent free radical scavenger

Idebenone Powder has strong free scavenging ability among several common antioxidants. At the same concentration, idebenone has a similar ability to scavenge DPPH and AAPH as water-soluble vitamin E. Its ability to scavenge ABTS free radicals, tyrosine free radicals and peroxynitrite anions is 50 times that of water-soluble vitamin E. %. Idebenone, ascorbic acid and vitamin E can effectively eliminate free radicals at lower concentrations (10nmol/L). Coenzyme Q10 and kinetin need to be at concentrations of 100nmol/L and 1000nmol/L respectively to show their ability to scavenge free radicals.

2. Inhibit lipid peroxidation

Compared with ascorbic acid (>20mol/L), a-tocopherol (100rtmol/L), and glutathione (50tzmol/L), low concentration of idebenone (10Fmol/L) showed stronger antioxidant It can effectively inhibit the formation of lipid peroxides.

3. Inhibit inflammation and repair cutin

The Caspase (caspase) family is an inflammatory process and plays a very important role in mediating apoptosis, of which Caspase-3 is an important one. In the experiment, 0.5t,mol/L diethyl maleate and 0.1Fmol/L hydrogen peroxide were used to activate Caspase-3 respectively, thus reflecting the degree of cell apoptosis. Studies have shown that 0.5~mol/L idebenone can significantly reduce the degree of apoptosis induced by diethyl maleate and hydrogen peroxide, thereby inhibiting the occurrence of inflammation and improving tissue repair capabilities.

4. Prevent and treat DNA damage

Studies have shown that with sufficient UVB irradiation, the production of photoproducts in keratinocytes without any antioxidants is 53%, the production of photoproducts with idebenone is 23%, and the photoinhibition rate is 43%, while vitamin C, agonist The photoproduct inhibition rates of coenzyme, coenzyme Q10 and alpha-lipoic acid were 36%, 36%, 4% and 0% respectively. Idebenone significantly reduces UVB damage to DNA.

5. Inhibit light damage

The study found that when UVB was used to irradiate skin that had been coated with antioxidants, the sunburn cells of the skin coated with 0.5 idebenone were reduced by 38% compared to the blank, while vitamin E, kinetin, coenzyme Q10 and alpha-lipoic acid were respectively Reductions of 30%, 20%, 10%, 9% and 0%. It can be seen that idebenone has the most significant effect in inhibiting photodamage.

6. Inhibit melanin production

The inhibitory effect of idebenone on melanin is positively correlated with its addition amount. High concentrations of idebenone and hydroquinone have similar effects; after a certain dilution, the inhibitory effect of hydroquinone on melanin disappears, while low concentrations of idebenone still show inhibitory effects.

Physical and chemical properties

Idebenone, also known as Hydroxydecyl Ubiquinone, is a yellow crystal or crystalline powder. It is a lipophilic compound and is structurally similar to coenzyme Q10, i.e. Ubiquinone. The molecule is 66% smaller than Coenzyme Q10, so it has better speed and effectiveness in penetrating deep into the skin. As an efficient antioxidant, it has cosmetic functions such as scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, and reducing pigmentation.

Applications of Idebenone Powder:

Has a coloring effect on the product

Suitable for all skin types and changes product appearance

Can be used in toners, facial masks and various skin care products as an antioxidant

Idebenone has the following application pain points in skin care products:

① Extremely unstable to light and heat, easy to degrade and deactivate;

② The idebenone molecule is highly polar and difficult to absorb through the skin and enter the anti-aging target parts and cells of the skin;

③ Idebenone is insoluble in water and has poor compatibility with cosmetic base.

solution:

Nanocarriers can effectively improve the light and thermal stability of idebenone. They have high compatibility and are easy to compound with various bases such as creams/essences/lotions/water/facial masks, and are suitable for transparent systems.

If you have any other questions, please contact email: sales@sxytorganic.com

Idebenone powder Supplier

YTBIO is committed to providing customers with the highest-quality Pure Idebenone powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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