Hydroxypinacolone Retinoate Powder

What is Hydroxypinacolone Retinoate?

Hydroxypinacolone retinoate powder is a retinol derivative that has the function of regulating the metabolism of the epidermis and stratum corneum. It can resist aging, reduce seborrhea, dilute epidermal pigment, and prevent skin aging and prevention. Acne, whitening and lightening effects. It ensures the powerful effects of retinol while greatly reducing its irritation. It is currently used for anti-aging and preventing recurrence of acne.

HPR Powder (HPR), a new type of retinoid, is a third-generation VA derivative, a milder and more efficient super vitamin A, with anti-aging, acne prevention, and whitening properties. It has functions such as lightening spots and regulating epidermal metabolism, and is widely used in cosmetics, medicine, personal care and other fields.

As a new generation of anti-aging ingredients in the vitamin A family, HPR has unique properties, mainly due to its special chemical structure.

The structure of HPR allows it to jump out of the traditional conversion chain of Class A derivatives (ester→alcohol→aldehyde), and convert it into A acid more quickly, and can directly bind to cellular retinoic acid receptors (RARs).

Traditional retinol esters need to undergo hydrolysis and two-step oxidation in the skin to become retinoic acid before they can be effective. The conversion efficiency is low, and increasing the dosage will cause irritation.

HPR is an ester based on retinoic acid, which can directly act by stimulating receptors without undergoing metabolic conversion.

What are the benefits?

Milder

Scientists compared the anti-aging and irritant effects of multiple vitamins A (including HPR, trans-retinoic acid, retinol, retinaldehyde, and retinyl palmitate) in an in vitro model of human skin. The study found that HPR-induced inflammation (marked by IL-1α) was weaker than retinoic acid. At a concentration of 10 times, the cytotoxicity was even lower. Therefore, HPR is a more stable and gentler alternative to retinoic acid and can be used in cosmetics.

More effective

Anti-aging and anti-wrinkle

Using hydroxypinacolone retinoate-containing products, dent volume, wrinkles and fine lines images collected locally from subjects on days 0 (W0), 14 days (W14), and 28 days (W28) can be observed. After using the serum sample containing WL-HPR1130 for 2 weeks and 4 weeks, the volume of dents at the corners of the eyes, wrinkles and fine lines of the subjects showed significant changes, showing a trend of reduction.

Promote keratin metabolism

Hydroxypinacolone Retinoate Powder (HPR) can reduce pores, reduce skin roughness and make skin smooth and smooth by accelerating keratin metabolism, allowing keratinocytes to differentiate normally, and promoting the synthesis of interkeratin lipids.

HPR reduces the blockage of hair follicles through keratin metabolism, inhibits the secretion of oil by sebaceous glands, thereby reducing acne and acne, and achieving the suppression and elimination of skin inflammation. It can also accelerate the discharge of melanocytes and reduce the production of melanocytes through keratin metabolism, thereby achieving a whitening effect.

More stable

The researchers tested the photosensitivity of retinoids. Among all the tested vitamins, retinyl palmitate (Rpal) and beta carotene (βcal) were more susceptible to photodegradation and were almost completely degraded after a week of exposure to light. , while hydroxypinacolone retinoate (HPR) only degraded 40% after one week. On average, light had the smallest effect on HPR stability of all the vitamins tested.

In addition, according to the experimental data of the paper, in the simulated long-term stability test (placed at 25°C, 60% humidity for 6 months), HPR is still very stable in the formula (basically unchanged from the initial 95% content); accelerated stability In the sex test (40℃, ultraviolet irradiation environment), HPR is still very stable in the formula. For several other class A derivatives, obvious degradation was shown.

Characteristic

We talked about the side chain modification of retinoids earlier. Why do we need to carry out side chain modification? Because it can bring different characteristics. Retinol is good, but it is not stable enough and is also relatively irritating. These problems can be solved through side chain modification, such as retinyl palmitate, which is much milder. However, the problem caused by side chain modification is that the effectiveness will be affected due to the increase in conversion steps. This is the same for vitamin C, vitamin E and other ingredients. Fortunately, there are many ways to modify side chains, and researchers can modify the structure in various ways, and then select those ingredients that are both mild and efficient. As far as retinol goes, I was lucky enough to find hydroxypinacolone retinoate (HPR), which is simply retinoic acid + pinacol.

The effects of using pinacol modification are direct effect, small molecular weight, easier transdermal absorption, low irritation, and high stability. It can be said that it has obvious advantages over other types of retinoids. A research summary by Ruth et al., included in the famous dermatology journal JID, used an in vitro human skin model to compare the anti-aging and irritation properties of various retinoids, including HPR, trans-retinoic acid, and retinoids. Alcohol, retinaldehyde, retinyl palmitate. It was found that at the same concentration, HPR has a stronger effect at the gene transcription level than retinol, retinaldehyde, and retinyl palmitate, and at a concentration of 10 times, the cytotoxicity is even lower, but at the transcription level Less effective than trans-retinoic acid. Compared with the untreated control, HPR significantly promoted the synthesis of procollagen. Histological examination showed that the highest dose of HPR had a stronger effect than trans-retinoic acid, but the induced inflammation (marked by IL-1α) was no greater than that of the latter. Stronger. Based on these results, it is believed that HPR is an alternative to retinoic acid for skin anti-aging, but has fewer skin side effects. Vincenzo Bettoli et al conducted a 12-month study to examine the ability of a formula containing HPR and retinol (Biretix gel®) to prevent acne recurrence. The patients first took isotretinoin orally for treatment in the first stage until the condition was relieved. Then they entered the second stage and used one form of this formula every day for 12 months. It was found that 15.38% of patients relapsed. The patients tolerated the formula well and no adverse reactions were reported. , indicating that the formula containing HPR and retinol is safe, tolerable and effective. Another clinical study conducted by S. Veraldi et al. also contained HPR and retinol in the formula, as well as papain. It was used on 98 acne patients for 12 consecutive weeks to evaluate the effect on acne. The skin lesions were reduced by an average of 40.8%, and only 15.3% of the patients experienced local discomfort. The study found that it contains HPR, retinol, and papain. Formulated to be safe and effective for acne care. In addition, relevant tests conducted by Nanjing Anyike showed that with a concentration of 0.5% as the test substance, no adverse reactions were found in the patch test, and no phototoxicity was shown. It is precisely because of the many advantages of HPR that brands including Estee Lauder have used it, and it has now begun to enter the formulation of domestic skin care products.

Hydroxypinacolone Retinoate supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk HPR Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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