Ergothioneine Powder

What is Ergothioneine Powder?

Ergothioneine, referred to as EGT, is a rare sulfur-containing amino acid. In 1909, Charles Tanret discovered this substance while studying ergot bacteria and named it ergothioneine [1]. It was subsequently found to be widely present in the blood, liver, kidneys, brain, skin and other organs of animals. Ergothioneine Powder is a naturally occurring cell protector and antioxidant in the human body. 

Ergothioneine Powder has strong antioxidant activity, cell protection ability and anti-inflammatory properties. It can scavenge free radicals, protect DNA, reduce oxidative damage, and maintain normal cell growth. Ergothioneine is a rare natural amino acid derivative. In 1909, while studying the ergot fungus that destroyed rye grains, Charles Tanret isolated a unique crystalline sulfur-containing compound, and later named this water-soluble thiol ergothioneine after the ergot fungus.

The mechanism of YTBIO ergothioneine scavenging free radicals

90% of the oxygen we breathe is used by mitochondria to generate cellular energy - Adenosine Triphosphate (ATP)

In addition, 0.2-2% oxygen will produce reactive oxides ROS, which are some free radicals with particularly active chemical properties. Among them, two types of ROS are particularly unstable due to lack of electrons, and therefore are the most toxic and harmful. They are [peroxide radical (•O2−)] and [hydroxyl radical (•OH)]. It will directly lead to inflammation, aging and death of lipids, proteins, polysaccharides and DNA in the skin.

The reason why ergothioneine EGT is valued by the industry is that it is currently the only one that can actively cross the cell membrane and enter cells, and neutralize [peroxide free radicals (•O2) without disturbing the balance of the body's original antioxidant defense system. −)] and [hydroxyl radical (•OH)] components.

Mechanism of action:

The movement of ergothioneine in the body depends on a special transporter OCTN1 (organic cation transporter N1, the product of the SLC22A4 gene). OCTN1 is present in keratinocytes and melanocytes and has a high affinity for ergothioneine. , so skin tissues and cells can easily accept, absorb, and make full use of ergothioneine.

Through OCTN1 present on the cell membrane and mitochondrial membrane, ergothioneine is transported to the mitochondria, the main "focus" of free radical production in cells, protecting the mitochondria from oxidative damage while directly scavenging reactive oxygen free radicals to achieve the goal of delaying the human body's The ultimate goal of cellular senescence.

What are the benefits of ergothioneine?

Ergothioneine: an excellent antioxidant inducer

Fibroblasts are the most common cells in connective tissue. They have strong functional activities and can secrete structural proteins that constitute the extracellular matrix. They are closely related to the aging process of the skin.

Ergothioneine protects human fibroblasts and improves their viability by reducing the degradation of matrix metalloproteinase-1 (MMP-1) and increasing the production of type I collagen;

Inhibits the generation of reactive oxygen free radicals caused by UVA in fibroblasts and the activation of transcription factor AP-1; at the same time, it upregulates Nrf2 factor (a basic leucine zipper protein) in fibroblasts as a response to oxidative and electrophilic stress (transducer, inhibits genome instability) nuclear translocation, and induces antioxidant gene expression and glutathione production in fibroblasts exposed to UVA irradiation through the Nrf2 pathway.

Glutathione is an abundant non-protein thiol in cells and acts as an antioxidant to protect cells from damage by reactive oxygen species. The effect of ergothioneine on glutathione levels in fibroblasts means that it is not just a A powerful antioxidant and a powerful inducer of antioxidants.

Anti-inflammation and other chronic diseases

Ergothioneine powder has been proven to inhibit the activation of NFkβ (nuclear transcription factor kβ) and the upregulation of TNF-α (tumor necrosis factor-α) caused by UVB irradiation;

Prevents the activation and increase of the inflammatory cytokines IL-8 (interleukin-8) and IL-6 (interleukin-6) in epithelial cells mediated by TNF-α;

And by activating the p38 and JNK signaling pathways to prevent cell death caused by free fatty acids, it can resist inflammation and even chronic diseases.

Pure ergothioneine whitens and inhibits melanin production

Studies have confirmed that ergothioneine's inhibitory effect on tyrosinase is better than common inhibitors, hindering pigment formation and deposition, brightening and whitening skin.

Comparative chart of the inhibition of tyrosinase bisphenolase activity by natural ergothioneine and Vc

After the positive control kojic acid treatment for 48 hours, the production of melanin in cells was inhibited, and the relative content of melanin was reduced, reaching 82.01% of that in the blank control group. When the concentration of ergothioneine is 0.25 mg/mL, the relative content of melanin in cells is 58.87% of the blank group, which is already better than the whitening effect of 25 μg/mL kojic acid.

What is the role of ergothioneine as a raw material?

Ergothioneine can not only be used in the field of cosmetics, but also has very good effects in dietary supplements, food additives and other fields.

One of the most important functions of ergothioneine is antioxidant. Although it can only capture a part of free radicals, its capture efficiency is very high, and it is very stable and not easily oxidized. In addition, at the molecular scale, especially at the molecular scale such as fibroblasts, it can inhibit some related signaling pathways. For example, AP-1 can promote some signaling pathways, while Nrf2 is related to activating antioxidant pathways. At the molecular scale, there have been many studies on ergothioneine in dermatology. For all signaling pathways related to ROS, ergothioneine has corresponding studies to prove that it can inhibit or promote the expression of related signaling pathways.

Regarding the antioxidant effect of ergothioneine, it can inhibit the amount of superoxide in mitochondria, increase the number of mitochondria, and increase the membrane potential of mitochondria. Essentially, they are all designed to prevent mitochondria from being damaged by excessive reactive oxygen species and to protect mitochondria.

In addition, regarding the sirt gene that everyone is more concerned about, a longevity protein of deacetylase, we found that ergothioneine also has a significant effect on the sirt gene in cells. As a food additive, ergothioneine has been approved as a new food ingredient in the EU. Mushrooms contain a particularly large amount of ergothioneine. Therefore, in places and people who eat more mushrooms, the average life expectancy will increase, and related neurodegenerative diseases will also decrease.

It is worth mentioning that as age increases, the content of ergothioneine in the human body will decrease. In addition, a very important point is that in some cases of neurodegeneration or cognitive decline, the content of ergothioneine in the body generally decreases. Therefore, ergothioneine is now considered to be related to aging and cognition. It is a biological signaling molecule.

In addition, in the cardiovascular field, after a large number of sample analyses, ergothioneine has been proven to reduce the risk of cardiovascular disease, which is its application in the oral field. By analyzing the drugs, researchers found that when we take drugs containing ergothioneine, we can increase the content of ergothioneine in the blood, but the content will not continue to increase. This is mainly because ergothioneine is stored in some form in some organs of our body, such as the liver or bone marrow.

When we encounter an oxidative crisis in our body, we will activate a certain mechanism to express its transporter transporter protein, allowing ergothioneine to be enriched in these organs that are susceptible to oxidative damage to inhibit the impact of ROS on it, so we Call it adaptive antioxidant behavior.

Finally, ergothioneine acts as a food additive to prevent food from spoiling. This can be proven through the apple experiment. When we apply ergothioneine on one side of the apple and not on the other, you will find that the antioxidant effect of ergothioneine is very obvious and has potential application in food preservatives.

Ergothioneine  Supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality Pure Ergothioneine Bulk and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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