Climbazol Powder

What is Climbazol?

Climbazol is a racemate composed of equimolar amounts of (R)- and (S)-Climbazol. The IUPAC name is (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl- 3,3-Dimethylbutan-2-one is a topically applied antifungal agent used to treat fungal skin infections in humans. It can be included in over-the-counter anti-dandruff shampoo formulations and skin treatment compositions to treat dandruff and eczema where fungal infections are the cause.

Climbazol powder is a typical azole fungicide, which mainly inhibits plasma fungal cell membrane degradation by non-competitively blocking the synthesis of lanosterol 14α-demethylase (also known as fungal CYP51) in P450 enzymes. An important component of ergosterol biosynthesis, enabling fungal cell death.

Climbazol has broad-spectrum bactericidal properties and is mainly used in anti-itch and anti-dandruff conditioning shampoos and hair care shampoos. It can also be used in antibacterial soaps, shower gels, medicated toothpaste, mouthwash and other high-end washing products.

Advantages of Climbazol

Good anti-dandruff effect: It has strong inhibitory effect on dandruff fungi, good effect, mild effect, and long-lasting anti-dandruff and anti-itching effect.

Compatibility: It can be compounded with various anionic, nonionic and zwitterionic surfactants without causing precipitation or layering. It is suitable for transparent, colorless and pearlescent hair products.

Stable: Does not decompose or hydrolyze within the pH range of 3-8, and has excellent thermal stability and light stability.

Safe and low-toxic: no irritation to skin and eyes.

Low dosage, low cost: widely used in shampoo.

Climbazol can kill Malassezia, Bacillus ovatus, and Pityriasis ovale, thereby inhibiting and eliminating dandruff and achieving the purpose of relieving itching. Because of its stable nature and difficulty in soluble in water, it does not cause irritation to the scalp and can inhibit Candida albicans, which causes oral gingivitis and periodontitis. Therefore, it is an important functional additive for daily chemical products and can be widely used in shampoos. , conditioner, shower gel, soap, toothpaste, mouthwash, etc. are being produced. In addition, Climbazol can also be used in the field of skin fungal infection treatment to produce eczema drugs.

The maximum concentration of Climbazol as a preservative is 0.5%, and the recommended dosage as an anti-dandruff ingredient in shampoo is 0.4-0.8%.

Mechanism

Climbazol Powder mainly works by non-competitively blocking the synthesis of lanosterol 14α-demethylase (also known as fungal CYP51) in P450 enzymes, thereby inhibiting the biosynthesis of ergosterol, an important component of plasma fungal cell membranes, making fungal cells die.

Application direction

1. It has very good spectral bactericidal properties, especially against fungi that cause dandruff. It is especially suitable for conditioning anti-dandruff and anti-itch shampoo and hair care products.

2. It has a very good effect on improving dandruff itching and skin fungal infections caused by Dandruff Sporax fungus. Antibacterial and sterilizing soaps, shower gels, even toothpaste and plain saliva can be added.

Climbazol supplier

Yuantai Organic Bio is committed to providing customers with the highest-quality bulk Climbazol Powder and services so that every consumer can enjoy natural, healthy, and high-quality food. If you have any inquiries or needs about our products, please feel free to contact us, and we will reply to you as soon as possible.

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