Citrus Flavonoids

What Are Citrus Flavonoids?

Citrus Flavonoids refer to citrus bioflavonoids, which are mainly found in the peel and capsule of citrus fruits. They are compounds with multiple biological activities. Citrus flavonoids can be roughly divided into categories according to the flavonoid structure: flavonoid glycosides, such as naringenin, hesperidin, etc.; polymethoxyflavonoids, such as citrus flavonoids. The human body cannot produce citrus flavonoids on its own, so it needs to be obtained from food, especially citrus fruits such as lemons and grapefruits. It has multiple biological activities, such as antioxidant and anti-inflammatory effects. It is rich in vitamin C, which can help reduce the damage of free radicals to the skin and has a good cosmetic effect. In addition, the citric acid in citrus flavonoids has a better effect on eliminating fatigue and can promote metabolism.

Efficacy

Antioxidant

It can effectively scavenge free radicals and reduce cell damage. Studies have shown that they can increase the level of antioxidant enzymes in the body, thereby protecting cells from oxidative stress.

Anti-inflammatory

It has shown significant effects in inhibiting the release of inflammatory mediators. These compounds can reduce inflammatory responses by reducing the levels of inflammatory markers such as C-reactive protein and interleukin-6.

Anti-aging

Due to its strong antioxidant capacity, it is also believed to help with anti-aging, by reducing free radical damage and extending the lifespan of cells.

Anti-glycation

Studies have found that it has effective anti-glycation properties, which is important for preventing cell damage and aging.

Regulates the intestinal microbiota

It can help regulate the intestinal microbiota, which is important for maintaining a healthy digestive system and overall health.

Promotes metabolism

These compounds can also promote sugar and lipid metabolism, help control blood sugar levels, and help prevent and manage diabetes.

Neuroprotective

It also shows some potential in neuroprotection, which can improve cognitive function and slow the progression of neurodegenerative diseases. They may have a preventive effect on diseases such as Alzheimer's and Parkinson's by reducing oxidative stress and inflammation.

Cardiovascular protection

Helps lower blood pressure, improves blood lipid profiles, and has the potential to prevent atherosclerosis. They can increase high-density lipoprotein levels while reducing low-density lipoprotein and total cholesterol concentrations.

Mechanism of anti-glycation action

Reactive carbonyl species (RCS) removal: It can block the binding of reactive carbonyl species such as methylglyoxal (MG) and glyoxal (GO) to proteins and DNA, preventing them from initiating glycation reactions.

Enhancing Glyoxalase-1 (GLO-1) activity: GLO-1 is an enzyme responsible for catalyzing the detoxification of methylglyoxal. It increases the efficiency of MG clearance in the body by enhancing the activity of GLO-1, thereby reducing the accumulation of glycation intermediates.

Activating the Nrf2/ARE signaling pathway: For example, hesperidin can activate the Nrf2/ARE signaling pathway, which is an important cell protection pathway that helps reduce oxidative stress and prevent cell damage.

Inhibiting the formation and accumulation of advanced glycation end products (AGEs): It indirectly inhibits the formation of AGEs, which are the result of glycation and oxidative stress and are associated with the development of complications of multiple chronic diseases such as diabetes.

Applications

Health food: As a natural antioxidant and immunomodulator, it is widely used in various health foods, such as antioxidant health products and immune enhancers.

Food: It can be used as a natural pigment and preservative to improve the appearance and taste of food and extend the shelf life of food.

Cosmetics: Its antioxidant properties are used in the development of anti-aging products to help delay the aging process of the skin.

Medicine: Due to its strong antioxidant ability, it is used in the medical field to treat cardiovascular diseases, diabetes and other diseases.

Formulation Of Citrus Flavonoids

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

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