Bulk Spermidine Powder

What is spermidine?

Bulk spermidine powder, also known as spermidine, is a natural polyamine present in organisms, an organic compound with multiple amine groups. Synthesis in organisms can be carried out through multiple pathways, including the action of two key enzymes, arginine oxidase and N-acetyl-L-arginase. It is widely distributed in organisms, including bacteria, mammals, birds, insects and plants, and is found in multiple organs such as human kidneys, liver, intestines and stomach.

It has multiple biological functions and plays an important role in cell proliferation, gene expression regulation and cell metabolism. As we age, endogenous spermidine levels decrease, and spermidine supplementation is believed to reverse cellular and body dysfunction associated with aging.

What are the health benefits?

Antioxidation: Spermidine has strong antioxidant activity, can react with free radicals, and reduce the oxidative damage of free radicals to cells. In the body, it can also promote the expression of antioxidant enzymes and enhance antioxidant capacity.

Energy metabolism regulation: It participates in regulating the energy metabolism of organisms, can promote the absorption and utilization of glucose after food intake, and affects the ratio of aerobic metabolism and anaerobic metabolism by regulating the effectiveness of mitochondrial energy production.

Growth and development and immune regulation: It also plays an important role in growth and development and immune regulation. It can promote the secretion of growth hormone in the human body and help enhance the development of various tissues and organs in the body. At the same time, in immune regulation, it enhances the body's resistance to viruses and diseases by regulating the production of white blood cells and promoting the removal of reactive oxygen.

Cardioprotection: It can inhibit circulating cytokines such as TNF-α, and synergize with arginine-derived nitric oxide to cause vasodilation and promote the phosphorylation state of cGMP/cGMP-dependent protein kinase (PKG), exerting cardiovascular protection. In addition, enhanced autophagy and mitochondrial autophagy also contribute to myocardial cell elasticity and mitochondrial function.

Delaying aging: It can promote autophagy, a cleaning process inside cells that helps remove damaged organelles and proteins, thereby delaying aging.

Improving reproductive health: Its levels decline during reproductive aging, and supplementing with spermidine may help improve ovarian function and extend reproductive life.

Glial cell regulation: It has an important regulatory role in glial cells. It can participate in the functional connection between cell signaling systems and nerve cells, and plays an important regulatory role in neuronal development, synaptic transmission, and combating neuropathy.

Cardiovascular protection: In the cardiovascular field, it can reduce lipid accumulation in atherosclerotic plaques, reduce cardiac hypertrophy, and improve diastolic function, thereby protecting the heart. In addition, dietary intake of spermidine can improve blood pressure and reduce the incidence and mortality of cardiovascular diseases.

Anti-aging mechanism: In organisms, the tissue concentration of spermidine powder decreases in an age-dependent manner, but healthy 90-year-olds and centenarians have spermidine levels close to those of young (middle-aged) individuals. Studies have found that individuals with higher spermidine intake have a lower incidence of cardiovascular disease, which is associated with improved overall survival.

Inducing autophagy: Currently, inducing autophagy is considered to be the main mechanism for delaying aging. Studies have found that spermidine induces protein kinase B dephosphorylation, triggering the forkhead box transcription factor O (FoxO) transcription factor to move to the nucleus, thereby increasing the transcription of the FoxO target gene autophagy microtubule-associated protein light chain 3 (LC3) and promoting autophagy.

Anti-aging mechanism

In organisms, the tissue concentration of spermidine powder decreases with age, but the spermidine levels in healthy 90-year-olds and centenarians are close to those in young (middle-aged) individuals. Studies have found that individuals who consume more spermidine have a lower incidence of cardiovascular disease, which is associated with improved overall survival.

Inducing autophagy

Currently, inducing autophagy is considered to be the main mechanism for delaying aging. Studies have found that spermidine induces protein kinase B dephosphorylation, triggering the forkhead box transcription factor O (FoxO) transcription factor to move into the nucleus, thereby increasing the transcription of the FoxO target gene autophagy microtubule-associated protein light chain 3 (LC3) and promoting autophagy.

Delaying telomere aging

Mice were given spermidine for 6 months starting at 17/18 months of age. The study found that it can delay the rate of telomere shortening compared to mice that were not given spermidine. In addition, this study also found that it can significantly regulate brain glucose metabolism levels, inhibit different cardiac inflammatory parameters, reduce the number of pathological spots in the kidneys and liver, and reduce age-induced hair loss.

Antioxidant and anti-inflammatory

Oxidative stress is an important factor that causes cell aging and damage, and it has an antioxidant effect. The researchers fed mice exogenous spermidine for three months and observed changes in the ovaries. In the spermidine treatment group, the number of atrophic hair follicles (degenerated hair follicles) was significantly reduced, the activity of antioxidant enzymes increased, the level of malondialdehyde (MDA) decreased, and the level of reactive oxygen species (ROS) decreased, indicating that the oxidative stress in the treatment group was reduced. With age, chronic inflammation seems to inevitably increase, which helps stimulate the production of anti-inflammatory cytokines while reducing the production of pro-inflammatory cytokines.

Inhibit stem cell aging

It can promote mitochondrial function and keratin production of epithelial stem cells, further ensuring muscle and hair follicle regeneration.

Application areas

Health products and nutritional supplements

As a natural, non-toxic functional nutritional factor, it is widely used in the field of health products and nutritional supplements. It has the effects of anti-aging, improving sleep, and enhancing physical strength, ensuring the high purity and high activity of the product, which is suitable for consumers who pursue a natural and healthy lifestyle.

Cosmetics

Due to its anti-aging and antioxidant properties, it can be used to develop new skin care products and improve skin condition.

Medicine

It is being studied for the treatment of diseases related to aging, such as cardiovascular disease and neurodegenerative diseases.

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Bulk Spermidine Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

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