Bulk L-Tryptophan Powder

What is L-Tryptophan?

Bulk L-Tryptophan Powder is an essential amino acid, which is naturally present in most high-protein food sources, such as chicken, eggs, cheese, fish, and some nuts. Being an essential amino acid means that we need to obtain it through our diet, as the body cannot synthesize it.

It is one of the amino acids required for protein synthesis in the body and is essential for cell growth and tissue repair. In addition, it is a precursor for some important biologically active substances, such as tryptophan derivatives, serotonin, and melatonin. It plays a variety of important functions in the human body.

Function

Serotonin synthesis: It is a precursor for the synthesis of the neurotransmitter serotonin. It can promote the synthesis of serotonin and has a positive effect on mental health and mood stability.

Melatonin synthesis: It is a precursor for the synthesis of melatonin. By converting it into melatonin, it can help regulate the sleep cycle and improve sleep quality.

Immune function: It is metabolized into a series of bioactive substances in immune cells, such as purine nucleotides and degradation product injections. These substances play an important role in regulating the activity of immune cells and immune responses.

Protein metabolism: It can be metabolized into other amino acids, such as tryptophan derivatives and allantoin. These metabolites are essential for the regulation of protein synthesis, decomposition and nitrogen balance.

Improve sleep quality: Increase melatonin and improve sleep quality by supplementing tryptophan.

Effects on Sleep

• Can help improve sleep quality by increasing serotonin levels. Serotonin itself is a neurotransmitter that has a positive effect on mood and sleep.
• By converting into 5-hydroxytryptamine, this chemical in turn converts to melatonin in the brain, increasing the body's sleepiness and helping people fall asleep more easily.
• Can help reduce anxiety and depression, which indirectly helps improve sleep quality, and the calming and soothing of emotions contributes to better sleep.
• Having a natural sedative effect, it can help the body naturally fall asleep without the need for medication, which is a good choice for those looking to improve their sleeping habits.

L-tryptophan intake determines the number of colonic regulatory T cells and susceptibility to colitis through GPR15 (G protein-coupled receptor 15)

L-Trp consumption determines the number of colonic CD4+ T cells through AhR-GPR15

In the absence of L-Trp in the spleen, an AhR- and GPR15-independent phenotype predominates.

L-Trp enhances GPR15 through AhR during CD4+ T cell activation and migration to the large intestine

The results suggest that dietary L-Trp can increase GPR15 expression by inducing Treg cells during naive T cell differentiation and their subsequent migration to the LILP.

L-Trp increases GPR15+ Treg cells through host IDO1/2 enzymes

The results suggest that microbiota-independent host L-Trp metabolism by IDO1/2 is the default pathway in response to L-Trp, selectively increasing colonic Treg cells through AhR and GPR15.

AhR ligands determine Treg or T effector cell-selective GPR15 expression

Different AhR ligands determine T cell type-specific GPR15 expression.

AhR directly controls transcriptional activation of Gpr15

Suggests that TF binding sites other than AhR binding sites influence GPR15 expression in these cells.

L-Trp supplementation reduces future risk of colitis via GPR15

Suggests that humans may consume more L-Trp to increase colonic GPR15+ Treg cells for therapeutic purposes.

Conclusion: L-Trp intake determines transcriptional levels of the colonic T cell homing receptor GPR15, thereby affecting colonic FOXP3+ Treg cell numbers and local immune homeostasis. Ingested L-Trp is converted into compounds by host IDO1/2 enzymes (but not gut microbiota) that preferentially induce GPR15 transcription in Treg cells via the aryl hydrocarbon receptor.

Dosage Recommendations

Daily supplementation

Adjust dosage based on serotonin levels, mild deficiency (500 mg), moderate deficiency (1000 mg), major deficiency (2000-3000 mg).

Improving sleep

Take 1000-2000 mg before bed to help improve sleep quality.

Sports supplements

EAA blends typically contain 50-1000 mg to improve muscle protein synthesis and amino acid uptake.

Application areas

Medicine and nutrition and health care: Helps improve sleep quality and is suitable for insomniacs. It is also used to treat depression, anxiety and other diseases.

‌Food: As a food additive, it is used in dairy products, meat products and baked goods to supplement essential amino acids for the human body and accelerate the synthesis of human protein.

‌Cosmetics: Applied in the cosmetics industry, as an amino acid whitening agent, it is gradually applied to skin care products to help improve skin conditions.

‌Feed: It can participate in the fat metabolism in animals and improve the growth efficiency of animals.

Formulation Of L-Tryptophan

Capusle Formulation

Tablet Formulation

Solid Drink Formula

Certificates

YTBIO is developing in an all-round way. We have our own factory, quality inspection and R&D team. We are committed to providing customers with the best quality Bulk L-Tryptophan Powder and services. It is our original intention to let every consumer enjoy high-quality and healthy products. If you have any needs or questions about our products, please feel free to contact us and we will reply you as soon as possible.

Packaging and Shipping

Our Factory