Bulk Ivermectin Powder

What is bulk Ivermectin powder

Bulk Ivermectin powder is white or slightly yellow crystalline powder, soluble in methanol, esters and aromatic hydrocarbons, insoluble in water. It is an antibiotic drug that has killing activity against nematodes, insects and mites. The injections and tablets made from it are mainly used to treat gastrointestinal nematode diseases, cattle fly maggots, skin fly maggots, sheep nose fly maggots and pig and sheep scabies in livestock. In addition, it can also be used to treat parasitic nematodes in poultry (such as roundworms, lung nematodes, etc.). It can also be made into agricultural insecticides and miticides to kill mites, diamondback moths, cabbage worms, leaf miners, psyllids, nematodes, etc. that are widely parasitic on plants. The outstanding features of this drug are: mild side effects, and one-time use of the drug can kill multiple parasites inside and outside the body at the same time.
It is a broad-spectrum antibiotic and belongs to the macrolide antibiotics. It is made by fermentation of Streptomyces and is the first macrolide antibiotic to be used on a large scale and approved for clinical application. It acts on the ribosomes of bacteria, inhibits protein synthesis, and then inhibits the growth and reproduction of bacteria. It has certain antibacterial activity against both Gram-positive bacteria and some Gram-negative bacteria.
It exerts its bactericidal effect mainly in the following three ways: first, it can bind to 23SIRNA on the ribosome to prevent protein synthesis; second, it can block the binding of the bacterial ribosome 30S subunit to mRNA, thereby hindering translation; finally, it can promote antibody-dependent cellular cytotoxicity and enhance the body's immune system's killing effect on bacteria.

Discovery process:

It is a derivative of avermectin. William C. Campbell and Satoshi Omura, the discoverers of avermectin, won the 2015 Nobel Prize in Physiology or Medicine for their outstanding achievements in combating river blindness and elephantiasis with their derivative ivermectin. In 1973, Japanese microbiologist Satoshi Ōmura discovered a new type of Streptomyces in the soil, which was successfully isolated and cultured in the laboratory. Satoshi Ōmura discovered that these streptomyces can produce antiparasitic substances. With the assistance of Merck's drug screening laboratory, researchers completed the purification and identification of the active ingredient in 1975 and named it avermectin. When it was discovered, it was considered to be a new type of antiparasitic drug with a new structure. In in vivo or in vitro experiments, it has the effect of killing various pathogens. It was first reported in a paper in 1979, which identified it as an 18-membered macrolide substance and introduced the method of obtaining the product by fermentation with Streptomyces avermectin. The avermectin family shows extraordinary potential for anthelmintics. The chemically modified structural analogue, ivermectin, is a safer and more effective product. It is a mixture of two chemically modified avermectin analogues, containing 80% 22,23-dihydroavermectin-B1a and 20% 22,23-dihydroavermectin-B1b.

Effects:

1. Antiviral effect
It can inhibit the replication and spread of viruses by enhancing the body's immunity. It has a certain effect on the treatment of viral infections such as influenza and colds, and can relieve related symptoms such as fever, cough and sore throat.
2. Antibacterial effect
It has an inhibitory effect on a variety of bacteria and can be used to treat diseases caused by bacterial infections. It is often used to treat diseases such as skin infections, respiratory infections and urinary tract infections, and shows good efficacy.
3. Antifungal effect
It has a good antibacterial effect on many fungi and can be used to treat diseases such as Candida albicans infection. It effectively reduces the occurrence of related symptoms and complications by inhibiting the growth and reproduction of fungi.
4. Anti-inflammatory effect
It can reduce the inflammatory response of the disease and has a certain effect on the treatment of diseases such as arthritis and skin inflammation. It regulates the body's immune system, reduces tissue damage and inflammatory response, and accelerates wound healing and tissue repair.

Efficacy

1. Disease prevention
It has obvious immunomodulatory function, which can enhance the body's immunity and improve the ability to resist viral infections. Long-term use of an appropriate amount of ivermectin powder can help prevent the occurrence of a variety of infectious diseases and chronic diseases.
2. Promote recovery
It has good antibacterial and anti-inflammatory effects, which can improve the patient's symptoms and accelerate tissue repair and recovery. It is widely used in postoperative recovery, chronic disease treatment and wound healing, helping patients to return to normal life as soon as possible.
3. Improve animal production efficiency
It has important effects in the breeding industry. It can improve the immunity and disease resistance of animals, improve survival rate and production efficiency. At the same time, it can also promote the digestion and absorption of feed, increase body weight and meat quality, thereby increasing the economic benefits of breeders.

Efficacy as an antiparasitic drug:

It is a new type of broad-spectrum, high-efficiency, low-toxic antibiotic antiparasitic drug, which has a good killing effect on parasites inside and outside the body, especially for nematodes and arthropods. It is the first avermectin drug derivative obtained by Merck Company of the United States after Wilkinson catalysis of the double bond between C22 and C23 of AVMB1 and hydrogenation treatment in a homogeneous system. It has basically the same insecticidal activity as avermectin (AVM), but IVM has stronger permeability and safety to mammalian body tissues. It can increase the release of inhibitory transmitter γ-aminobutyric acid of nematodes and arthropods, open the Cl ion channel controlled by glutamate, enhance the permeability of nerve membrane to Cl, thereby blocking the transmission of nerve signals, causing nerve paralysis, and then muscle cells lose the ability to contract, and finally leading to the death of the worm. The peripheral neurotransmitter of mammals is acetylcholine. Although GABA is distributed in the central nervous system, this type of drug has little effect on the blood-brain barrier because it is not easy to pass through the blood-brain barrier. Therefore, it is relatively safe to use.
It is a new type of broad-spectrum, high-efficiency, low-toxic antibiotic antiparasitic drug, which has a good expelling effect on parasites inside and outside the body, especially nematodes and arthropods. But it is ineffective against tapeworms, flukes and protozoa.
The expelling and killing effect of macrolide antiparasitic drugs on nematodes and arthropods is to increase the release of the inhibitory transmitter γ-aminobutyric acid of the worm body, open the Cl- channel controlled by glutamate, enhance the permeability of the nerve membrane to Cl-, thereby blocking the transmission of nerve signals, and finally paralyzing the nerves, making the muscle cells lose the ability to contract, and finally causing the death of the worm body.
It is mainly used to expel gastrointestinal nematodes and external parasites of poultry. It has a good expelling and killing effect on most parasites in poultry, and it is also effective for poultry external parasites such as larvae of skin flies and nose flies, as well as scabies, hair lice and blood lice. It is mainly used clinically to expel poultry nematodes such as Ascaris galli, Capillaria occludens, and arthropods parasitic on poultry such as knee mites, etc., and it is highly effective for oral administration and subcutaneous injection.

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